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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.02799988 23.67700005 Tm 0 g [(NLRP3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.56700134 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.27099609 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(NLRP)1(3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 82.76399994 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 166.76400757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NLRP)1(3)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 90.63899994 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 93.01300049 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 126.21499634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 128.58900452 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 188.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 190.94299316 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 225.41700745 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(1-301)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(NLRP)1(3)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 385.43200684 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.02500153 16.35000038 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NLR)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 17.81100082 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 22.31100082 11.72200012 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 50.55899811 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 55.05899811 11.72200012 Tm [(pyrin)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 76.94799805 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 81.44799805 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 114.27500153 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 118.77500153 11.72200012 Tm [(containing)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 164.52200317 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 169.02200317 11.72200012 Tm [(3)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 174.30000305 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 106.02500153 31.95000076 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(AII;)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 13.78999996 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 18.29000092 11.72200012 Tm [(AVP;)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 38.38199997 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 42.88199997 11.72200012 Tm [(FCU;)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 62.56999969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 67.06999969 11.72200012 Tm [(MWS;)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 92.38200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 96.88200378 11.72200012 Tm [(FCAS;)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 121.3769989 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 125.8769989 11.72200012 Tm [(CIAS1;)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 153.51400757 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 158.01400757 11.72200012 Tm [(NALP3;)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 189.23300171 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 193.73300171 11.72200012 Tm [(C1orf7;)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 224.7539978 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 229.2539978 11.72200012 Tm [(CLR1.1)-1(;)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 260.65701294 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 265.15701294 11.72200012 Tm [(PY)1(PAF1;)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 300.15899658 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 304.65899658 11.72200012 Tm [(A)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GTAVPR)1(L)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 40.27099991 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 107 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.02500153 16.35000038 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(P20)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 33.95199966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 113 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.02500153 16.35000038 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 114 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(17)-1(21)-1(1)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 116 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 117 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.02500153 16.35000038 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 118 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 134 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 137 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.02500153 16.35000038 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 138 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 142 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 143 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.02500153 16.35000038 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 144 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 105.27500153 0.75 l 105.27500153 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 106.27500153 -0.25 l 106.27500153 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 156 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 157 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.02500153 0.75 m 426.17498779 0.75 l 426.17498779 141.1499939 l 106.02500153 141.1499939 l h f* Q q 1 0 0 1 105.65000153 0 cm -0.625 -0.25 m 321.5249939 -0.25 l 321.5249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 158 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pyrin-like)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 138.24899292 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 142.74899292 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 174.05599976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 178.55599976 11.72200012 Tm [(containing)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 224.30299377 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 228.80299377 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 233.77799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 238.27799988 11.72200012 Tm [(pyrin)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 260.16699219 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 264.66699219 11.72200012 Tm [(do)1(main,)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 299.66101074 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 304.16101074 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 309.13598633 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nuc)-1(leotid)1(e)-1(-)1(binding)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 82.47699738 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 86.97699738 27.3220005 Tm [(site)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 101.9980011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 106.4980011 27.3220005 Tm [(\(NBS)-1(\))] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 130.66799927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 135.16799927 27.3220005 Tm [(do)1(main,)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 170.16200256 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 174.66200256 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 190.93899536 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 195.43899536 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 200.41400146 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 204.91400146 27.3220005 Tm [(leu)-1(cine)-1(-)1(ric)-1(h)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 255.30200195 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 259.80200195 27.3220005 Tm [(repeat)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 287.52700806 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 292.02700806 27.3220005 Tm [(\(LRR)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(\))] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 3.00600004 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 7.50600004 42.92200089 Tm [(mot)1(if.)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 32.69499969 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 37.19499969 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 54.45700073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 58.95700073 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 90.26399994 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 94.76399994 42.92200089 Tm [(interacts)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 131.60800171 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 136.10800171 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 154.5039978 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 159.0039978 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 173.00500488 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 177.50500488 42.92200089 Tm [(ap)1(opt)1(osis-a)1(ssociated)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 268.51998901 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 273.01998901 42.92200089 Tm [(speck)-1(-)1(l)-1(ik)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 40.9129982 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 45.4129982 58.52199936 Tm [(PY)1(CARD)1(/)-1(A)1(SC,)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 104.9940033 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 109.4940033 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 134.59100342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 139.09100342 58.52199936 Tm [(contains)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 175.30599976 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 179.80599976 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 184.78100586 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 189.28100586 58.52199936 Tm [(caspa)1(se)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 222.92999268 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 227.42999268 58.52199936 Tm [(rec)-1(ruit)1(me)-1(nt)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 277.65499878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 282.15499878 58.52199936 Tm [(do)1(mai)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n,)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 7.71199989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 12.21199989 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 28.48900032 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 32.98899841 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 39.54999924 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 44.04999924 74.12200165 Tm [(a)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 49.02500153 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 53.52500153 74.12200165 Tm [(member)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 89.78900146 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 94.28900146 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 103.1309967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 107.6309967 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 121.63200378 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 126.13200378 74.12200165 Tm [(NALP3)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 155.18400574 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 159.68400574 74.12200165 Tm [(inflammas)1(ome)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 223.38299561 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 227.88299561 74.12200165 Tm [(complex.)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 266.5289917 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 271.0289917 74.12200165 Tm [(This)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 288.29098511 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 292.79098511 74.12200165 Tm [(com)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(plex)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 17.81100082 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 22.31100082 89.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 62.2179985 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 66.71800232 89.72200012 Tm [(as)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 75.85900116 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 80.35900116 89.72200012 Tm [(an)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 90.87999725 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 95.37999725 89.72200012 Tm [(upst)1(re)-1(a)1(m)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 136.14399719 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 140.64399719 89.72200012 Tm [(activat)1(or)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 178.08999634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 182.58999634 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 191.43200684 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 195.93200684 89.72200012 Tm [(NF-kapp)1(aB)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 243.91600037 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 248.41600037 89.72200012 Tm [(signaling,)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 289.51400757 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 294.01400757 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 310.29098511 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(it)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 5.74800014 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 10.24800014 105.3219986 Tm [(plays)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 32.29499817 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 36.79499817 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 41.77000046 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 46.27000046 105.3219986 Tm [(role)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 62.93000031 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 67.43000031 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 75.3710022 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 79.8710022 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 93.87200165 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 98.37200165 105.3219986 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 142.60299683 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 147.10299683 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 155.94500732 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 160.44500732 105.3219986 Tm [(inflammat)1(ion,)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 219.89900208 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 224.39900208 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 238.3999939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 242.8999939 105.3219986 Tm [(immun)-1(e)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 278.35900879 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 282.85900879 105.3219986 Tm [(respon)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(se,)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 11.43900013 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 15.93900013 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 32.2159996 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 36.7159996 120.92199707 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 80.8769989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 85.3769989 120.92199707 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 129.22599792 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 133.72599792 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 141.66700745 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 146.16700745 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 161.6230011 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 166.1230011 120.92199707 Tm [(gene)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 187.63900757 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 192.13900757 120.92199707 Tm [(are)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 205.65699768 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 210.15699768 120.92199707 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 255.28399658 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 259.78399658 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 278.17999268 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 282.67999268 120.92199707 Tm [(fa)1(mi)-1(lia)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(l)] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 2.39499998 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 6.89499998 136.52200317 Tm [(cold)] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 25.28199959 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 29.78199959 136.52200317 Tm [(auto)1(in)-1(f)1(lammat)1(ory)] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 106.9240036 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 111.4240036 136.52200317 Tm [(syndrome)] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 154.35400391 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 158.85400391 136.52200317 Tm [(\(FCAS\),)] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 189.36099243 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 193.86099243 136.52200317 Tm [(Muc)-1(kle)-1(-)1(Wells)] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 252.22900391 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 256.72900391 136.52200317 Tm [(syndrome)] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 299.65899658 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 304.15899658 136.52200317 Tm [(\()] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 0.75 m 105.65000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 17.10000038 m 105.65000153 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 49.05000305 m 105.65000153 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 65.40000153 m 105.65000153 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 81.75 m 105.65000153 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 98.09999847 m 105.65000153 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 114.44999695 m 105.65000153 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.65000153 130.80000305 m 105.65000153 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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