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[(MMP1)1(3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.14700317 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.14700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MMP1)1(3)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 97.02200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 99.39600372 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 132.5980072 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 134.97200012 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 194.95199585 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 197.32600403 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 231.80000305 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(350)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(MMP1)1(3)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 334.87799072 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 61 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 96.47499847 16.35000038 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Mat)1(rix)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 27.51399994 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 32.01399994 11.72200012 Tm [(metallop)1(rot)1(e)-1(inase-13)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 124.39600372 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 96.47499847 16.35000038 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 71 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CLG3,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 24.77599907 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 29.27599907 11.72200012 Tm [(MAND)1(P1)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 69.35900116 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 96.47499847 16.35000038 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P45)-1(45)-1(2)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 96.47499847 16.35000038 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(67)-1(52)-1(2)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 96.47499847 16.35000038 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 96.47499847 16.35000038 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 107 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 112 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 96.47499847 16.35000038 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 95.72499847 0.75 l 95.72499847 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 96.72499847 -0.25 l 96.72499847 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 125 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 126 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 96.47499847 0.75 m 426.17501831 0.75 l 426.17501831 156.75 l 96.47499847 156.75 l h f* Q q 1 0 0 1 96.09999847 0 cm -0.625 -0.25 m 331.07501221 -0.25 l 331.07501221 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 35.23099899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 39.73099899 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 48.57300186 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 53.07300186 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 67.0739975 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 71.5739975 11.72200012 Tm [(mat)1(rix)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 98.72799683 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 103.22799683 11.72200012 Tm [(metallop)1(rot)1(e)-1(inase)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 181.16099548 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 185.66099548 11.72200012 Tm [(\(MMP\))] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 214.76600647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 219.26600647 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 245.3480072 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 249.8480072 11.72200012 Tm [(are)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 263.36599731 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 267.86599731 11.72200012 Tm [(involved)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 304.23498535 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 308.73498535 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 316.67599487 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 14.0010004 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 18.50099945 27.3220005 Tm [(breakdo)1(wn)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 66.79699707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 71.29699707 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 80.13899994 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 84.63899994 27.3220005 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 136.83299255 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 141.33299255 27.3220005 Tm [(mat)1(rix)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 168.48699951 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 172.98699951 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 180.92799377 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 185.42799377 27.3220005 Tm [(normal)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 215.93499756 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 220.43499756 27.3220005 Tm [(ph)1(y)-1(sio)1(l)-1(o)1(gic)-1(a)1(l)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 276.92199707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 281.42199707 27.3220005 Tm [(pro)1(c)-1(esse)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s,)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 6.33300018 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 10.83300018 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 30.60000038 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 35.09999847 42.92200089 Tm [(as)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 44.24100113 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 48.74100113 42.92200089 Tm [(embryonic)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 94.40499878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 98.90499878 42.92200089 Tm [(development,)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 158.06900024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 162.56900024 42.92200089 Tm [(repro)1(duc)-1(t)1(ion,)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 221.01600647 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 225.51600647 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 241.79299927 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 246.29299927 42.92200089 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 271.0249939 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 275.5249939 42.92200089 Tm [(remodelin)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(g,)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 7.92299986 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 12.42300034 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 21.56399918 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 26.06399918 58.52199936 Tm [(well)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 43.06600189 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 47.56600189 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 56.70700073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 61.20700073 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 69.14800262 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 73.64800262 58.52199936 Tm [(disease)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 105.31900024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 109.81900024 58.52199936 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 154.11599731 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 158.61599731 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 178.38299561 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 182.88299561 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 192.02400208 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 196.52400208 58.52199936 Tm [(art)1(hrit)1(is)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 229.57499695 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 234.07499695 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 250.352005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 254.852005 58.52199936 Tm [(metast)1(asis.)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 302.10598755 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 306.60598755 58.52199936 Tm [(Mo)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(st)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 7.51900005 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 12.01900005 74.12200165 Tm [(MMP's)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 41.58499908 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 46.08499908 74.12200165 Tm [(are)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 59.60300064 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 64.10299683 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 100.64800262 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 105.14800262 74.12200165 Tm [(as)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 114.28900146 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 118.78900146 74.12200165 Tm [(inac)-1(t)1(ive)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 151.79600525 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 156.29600525 74.12200165 Tm [(pro)1(pro)1(tei)-1(ns)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 206.67500305 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 211.17500305 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 236.27200317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 240.77200317 74.12200165 Tm [(are)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 254.28999329 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 258.79000854 74.12200165 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 297.94100952 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 302.44100952 74.12200165 Tm [(wh)1(e)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 5.546 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 10.04599953 89.72200012 Tm [(cl)-1(eaved)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 42.6230011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 47.1230011 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 57.63499832 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 62.13499832 89.72200012 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 114.32900238 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 118.82900238 89.72200012 Tm [(pro)1(tein)-1(a)1(se)-1(s)1(.)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 170.71499634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 175.21499634 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 191.02200317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 195.52200317 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 226.82899475 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 231.32899475 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 268.83599854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 273.33599854 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 283.84799194 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 288.34799194 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 303.8039856 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 308.3039856 89.72200012 Tm [(ge)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ne)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 10.65200043 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 15.15200043 105.3219986 Tm [(cl)-1(eaves)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 46.13800049 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 50.63800049 105.3219986 Tm [(type)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 69.60900116 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 74.10900116 105.3219986 Tm [(II)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 79.40000153 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 83.90000153 105.3219986 Tm [(collagen)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 120.30899811 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 124.80899811 105.3219986 Tm [(more)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 147.50700378 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 152.00700378 105.3219986 Tm [(efficie)-1(ntly)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 193.82099915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 198.32099915 105.3219986 Tm [(th)1(an)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 217.73599243 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 222.23599243 105.3219986 Tm [(types)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 245.3730011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 249.8730011 105.3219986 Tm [(I)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 252.51899719 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 257.01901245 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 273.29598999 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 277.79598999 105.3219986 Tm [(III.)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 287.89898682 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 292.39898682 105.3219986 Tm [(It)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 298.39801025 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 302.89801025 105.3219986 Tm [(may)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 321.06900024 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(be)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 10.85400009 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 15.35400009 120.92199707 Tm [(involved)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 51.72299957 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 56.22299957 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 64.16400146 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 68.66400146 120.92199707 Tm [(art)1(ic)-1(ular)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 103.68800354 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 108.18800354 120.92199707 Tm [(cartilag)1(e)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 145.09300232 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 149.59300232 120.92199707 Tm [(turnov)1(e)-1(r)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 186.46299744 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 190.96299744 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 207.24000549 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 211.74000549 120.92199707 Tm [(cartilag)1(e)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 248.64500427 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 253.14500427 120.92199707 Tm [(pa)1(tho)1(physiolog)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(y)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 4.76399994 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 9.26399994 136.52200317 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 54.39099884 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 58.89099884 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 77.28700256 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 81.78700256 136.52200317 Tm [(ost)1(e)-1(o)1(art)1(hritis.)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 141.07400513 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 145.57400513 136.52200317 Tm [(The)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 161.3809967 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 165.8809967 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 187.39700317 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 191.89700317 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 198.45799255 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 202.95799255 136.52200317 Tm [(pa)1(rt)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 220.47000122 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 224.97000122 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 233.81199646 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 238.31199646 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 243.28700256 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 247.78700256 136.52200317 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 276.30300903 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 280.80300903 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 289.64498901 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 294.14498901 136.52200317 Tm [(MMP)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 317.23800659 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(gene)-1(s)] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 25.68199921 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 30.18199921 152.12199402 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 55.27899933 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 59.77899933 152.12199402 Tm [(localize)] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 91.70500183 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 96.20500183 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 105.27999878 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 109.77999878 152.12199402 Tm [(chromos)1(ome)] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 166.57499695 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 171.07499695 152.12199402 Tm [(11)-1(q)1(2)-1(2.3.)] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 207.55400085 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 0.75 m 96.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 17.10000038 m 96.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 33.45000076 m 96.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 49.80000305 m 96.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 66.15000153 m 96.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 82.5 m 96.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 98.84999847 m 96.09999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 96.09999847 115.19999695 m 96.09999847 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92501831 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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