%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.88999939 23.67700005 Tm 0 g [(MMP9)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.70599365 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.41000366 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(MMP9)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.8259964 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.82600403 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MMP9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.7009964 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.07499695 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.27700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.65100098 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.6309967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.00500488 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.47900391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(180)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(MMP9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.55700684 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 108.27500153 31.95000076 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(mat)1(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.15399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.65399933 11.72200012 Tm [(metallop)1(e)-1(p)1(tida)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.38700104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.88700104 11.72200012 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.16500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.66500092 11.72200012 Tm [(\(gelat)1(i)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.44500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.94500732 11.72200012 Tm [(B,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.75799561 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.25799561 11.72200012 Tm [(92)-1(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.04400635 11.72200012 Tm [(gelat)1(i)-1(na)1(se)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.98400879 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.48400879 11.72200012 Tm [(92)-1(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.76998901 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.26998901 11.72200012 Tm [(ty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.85400009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.35400009 27.3220005 Tm [(IV)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.08600044 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.58600044 27.3220005 Tm [(collagenase\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.2480011 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.27500153 16.35000038 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(GE)1(L)-1(B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.07299995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.57299995 11.72200012 Tm [(CLG4B)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.99599838 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.49599838 11.72200012 Tm [(MMP-9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.92700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.42700195 11.72200012 Tm [(MAND)1(P2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.50999451 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.27500153 16.35000038 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P14)-1(78)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.27500153 16.35000038 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(06)-1(09)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.27500153 16.35000038 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.27500153 16.35000038 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.27500153 16.35000038 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 107.52500153 0.75 l 107.52500153 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 108.52500153 -0.25 l 108.52500153 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.27500153 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 108.27500153 94.34999847 l h f* Q q 1 0 0 1 107.90000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.23099899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.73099899 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.57300186 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.07300186 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.0739975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.5739975 11.72200012 Tm [(mat)1(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.72799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.22799683 11.72200012 Tm [(metallop)1(rot)1(e)-1(inase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.16099548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.66099548 11.72200012 Tm [(\(MMP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.76600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.26600647 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.3480072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.8480072 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.36599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.86599731 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.23498535 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.73498535 11.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.04700089 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.54700089 27.3220005 Tm [(breakdo)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.84300232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.34300232 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.18499756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.68499756 27.3220005 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.8789978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.3789978 27.3220005 Tm [(mat)1(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.53300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.03300476 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.97399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.47399902 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.98100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.48100281 27.3220005 Tm [(ph)1(y)-1(sio)1(l)-1(o)1(gic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.96798706 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.46798706 27.3220005 Tm [(pro)1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(esse)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.87700081 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.37700081 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.14400101 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.64400101 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.78499985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.28500366 42.92200089 Tm [(embryonic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.9489975 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.4489975 42.92200089 Tm [(development,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.61300659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.11300659 42.92200089 Tm [(repro)1(duc)-1(t)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.55999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.05999756 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.33700562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.83700562 42.92200089 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.56900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.06900024 42.92200089 Tm [(rem)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(od)1(e)-1(ling,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.84400177 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.34400177 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.48500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.98500061 58.52199936 Tm [(well)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.98699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.48699951 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.62799835 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.12799835 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.06900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.56900024 58.52199936 Tm [(disease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.24000549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.74000549 58.52199936 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.03700256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.53700256 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.30400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.80400085 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.94500732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.44500732 58.52199936 Tm [(art)1(hrit)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.4960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.9960022 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.27301025 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.77301025 58.52199936 Tm [(metas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ta)1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.22100067 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.72100067 74.12200165 Tm [(Most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.75500107 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.25500107 74.12200165 Tm [(MMP's)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.82099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.32099915 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.83899689 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.33899689 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.88400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.38400269 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.5249939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.0249939 74.12200165 Tm [(inac)-1(t)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.03199768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.53199768 74.12200165 Tm [(pro)1(pro)1(tei)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.91099548 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.41099548 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.50799561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.00799561 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.52600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.02600098 74.12200165 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(tiva)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.66300011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.1629982 89.72200012 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.46300125 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.96300125 89.72200012 Tm [(cl)-1(eaved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.54000092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.04000092 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.55200195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.05200195 89.72200012 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.2460022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.7460022 89.72200012 Tm [(pro)1(tein)-1(a)1(se)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.63200378 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 0.75 m 107.90000153 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 32.70000076 m 107.90000153 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 49.05000305 m 107.90000153 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 65.40000153 m 107.90000153 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 81.75 m 107.90000153 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 98.09999847 m 107.90000153 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 114.44999695 m 107.90000153 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.90000153 130.80000305 m 107.90000153 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 574.73999023 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>