%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.74299622 23.67700005 Tm 0 g [(KRT40)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 150.85299683 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.55700684 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(KRT40)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 82.04199982 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 166.04200745 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(KRT40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.91699982 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.29100037 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.49299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.86699677 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.84700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.22099304 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.69500732 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(90-43)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(KRT40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.03100586 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ke)-1(ra)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.71100044 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.21099854 11.72200012 Tm [(40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.76699829 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(K40)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.43499947 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.93499947 11.72200012 Tm [(KA)1(3)-1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.70299911 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.20299911 11.72200012 Tm [(CK-)1(4)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.38600159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q6A16)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.77799988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(30)-1(39)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 100.77500153 94.34999847 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.2480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.7480011 11.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.39399719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.89399719 11.72200012 Tm [(\(acidic)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.45399475 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.95399475 11.72200012 Tm [(ke)-1(ra)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.66500854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.16500854 11.72200012 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.41299438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.91299438 11.72200012 Tm [(wh)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55500031 27.3220005 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.99499893 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.49499893 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.56999969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.06999969 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.07099915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.57099915 27.3220005 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.65499878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.15499878 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.99699402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.49699402 27.3220005 Tm [(intermediate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.45899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.95899963 27.3220005 Tm [(filament)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.28199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.78199768 27.3220005 Tm [(\(IF\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.22000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.72000122 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.35900879 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.85900879 27.3220005 Tm [(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(eratins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.97800064 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.47800064 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.99599838 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.49599838 42.92200089 Tm [(heterop)1(olyme)-1(ric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.27400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.77400208 42.92200089 Tm [(st)1(ruc)-1(tura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.4940033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.9940033 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.46699524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.96699524 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.06399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.56399536 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.2749939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.7749939 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.77600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.27600098 42.92200089 Tm [(interm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.69199944 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.19199944 58.52199936 Tm [(filament.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.68199921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.18199921 58.52199936 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.26200104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.76200104 58.52199936 Tm [(filaments,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.41799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.91799927 58.52199936 Tm [(along)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.31199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.81199646 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.20799255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.70799255 58.52199936 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.49000549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.99000549 58.52199936 Tm [(mic)-1(r)1(ofilaments)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.97900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.47900391 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.75601196 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mic)-1(r)1(otubules,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.52600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.02600098 74.12200165 Tm [(compose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.43599701 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.93599701 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.93699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.43699646 74.12200165 Tm [(cy)-1(t)1(oske)-1(leton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.08299255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.58299255 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.42500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.92500305 74.12200165 Tm [(epith)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.33500671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.83500671 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.57699585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.07699585 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.88400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.38400269 74.12200165 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.35501099 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.85501099 74.12200165 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.50100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ke)-1(ra)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.71100044 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.21099854 89.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.89300156 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.39299774 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.91100311 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.41100311 89.72200012 Tm [(cl)-1(ust)1(e)-1(r)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.79000092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.29000092 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.23100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.73100281 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.70599365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.20599365 89.72200012 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.16799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.66799927 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.50999451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.00999451 89.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.80499268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.30499268 89.72200012 Tm [(17)-1(q12-q21.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.54598999 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 0.75 m 100.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 17.10000038 m 100.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 33.45000076 m 100.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 49.80000305 m 100.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 66.15000153 m 100.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 82.5 m 100.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 98.84999847 m 100.40000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 115.19999695 m 100.40000153 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 559.14001465 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>