%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.31800079 23.67700005 Tm 0 g [(KRT4)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 145.27799988 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 321.98199463 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(KRT4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 76.72000122 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 160.72000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(KRT4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.59500122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.96900177 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.17099762 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.54499817 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.5249939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.89900208 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.3730011 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(151-4)1(61)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(KRT4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.03100586 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ke)-1(ra)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.71100044 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.21099854 11.72200012 Tm [(4,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.65499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.15499878 11.72200012 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.12599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.62599945 11.72200012 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.91699982 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(K4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.15699959 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.65699959 11.72200012 Tm [(CK4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.83499908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.33499908 11.72200012 Tm [(CK-)1(4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.40599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.90599823 11.72200012 Tm [(CY)1(K4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.51499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.01499939 11.72200012 Tm [(WSN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.96199799 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P19)-1(01)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(42)-1(17)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 100.77500153 16.35000038 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 100.02500153 0.75 l 100.02500153 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 101.02500153 -0.25 l 101.02500153 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 100.77500153 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 100.77500153 94.34999847 l h f* Q q 1 0 0 1 100.40000153 0 cm -0.625 -0.25 m 326.7749939 -0.25 l 326.7749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(ke)-1(ra)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.95901489 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.45901489 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.9750061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.4750061 11.72200012 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(amily.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.12800026 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.62800026 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.43500137 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.93500137 27.3220005 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.90599823 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.40599823 27.3220005 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.6969986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.1969986 27.3220005 Tm [(cy)-1(t)1(oke)-1(ra)1(tins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.42599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.92599487 27.3220005 Tm [(consist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.78700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.28700256 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.1289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.6289978 27.3220005 Tm [(ba)1(sic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.42599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.92599487 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.08399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.58399963 27.3220005 Tm [(ne)-1(ut)1(ral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.94100952 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.44100952 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.91400146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.41400146 27.3220005 Tm [(wh)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.05500031 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55500031 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.07299995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.57300186 42.92200089 Tm [(arr)1(anged)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.56099701 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.06099701 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.0019989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.5019989 42.92200089 Tm [(pa)1(i)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.22200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.72200012 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.56400299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.06400299 42.92200089 Tm [(heterot)1(ypic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.10299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.60299683 42.92200089 Tm [(ke)-1(ra)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.31399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.81399536 42.92200089 Tm [(chains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.94999695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.44999695 42.92200089 Tm [(coe)-1(x)1(pressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.83898926 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.33898926 42.92200089 Tm [(du)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ring)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.13400078 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.63400078 58.52199936 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.95999908 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.45999908 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.30200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.80200195 58.52199936 Tm [(simple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.04600525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.54600525 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.82299805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.32299805 58.52199936 Tm [(st)1(ratif)1(ie)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.38000488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.88000488 58.52199936 Tm [(epith)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.28999329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.78999329 58.52199936 Tm [(tiss)1(u)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.85501099 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.35501099 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.61700439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.11700439 58.52199936 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.0880127 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.29099989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.79100037 74.12200165 Tm [(cy)-1(t)1(oke)-1(ra)1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.85400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.35400009 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.91500092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.41500092 74.12200165 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.90000153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.40000153 74.12200165 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.55400085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.05400085 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.99499512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.49499512 74.12200165 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.02099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.52099609 74.12200165 Tm [(laye)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.36300659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.86300659 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.70498657 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.20498657 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.20599365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.70599365 74.12200165 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(uc)-1(o)1(sal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.31599998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.81599998 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.0929985 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5929985 89.72200012 Tm [(esoph)1(ageal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.08399963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.58399963 89.72200012 Tm [(epith)1(e)-1(lia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.59899902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.09899902 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.49499512 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.99499512 89.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.07699585 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.57699585 89.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.84100342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.34100342 89.72200012 Tm [(KRT13)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.81100464 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 0.75 m 100.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 17.10000038 m 100.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 33.45000076 m 100.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 49.80000305 m 100.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 66.15000153 m 100.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 82.5 m 100.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 98.84999847 m 100.40000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.40000153 115.19999695 m 100.40000153 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 559.14001465 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>