%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 98.47899628 23.67700005 Tm 0 g [(JUN)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 140.11599731 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 316.82000732 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(JU)1(N)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 71.98799896 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.98800659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(JU)1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.86299896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.23699951 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.43900299 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.81300354 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.79299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.16700745 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.64100647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(250)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(JU)1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.71899414 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.52500153 16.35000038 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(jun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.49600029 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.99600029 11.72200012 Tm [(pro)1(to-)1(onc)-1(o)1(gen)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.88899994 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.52500153 16.35000038 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(AP)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.28300095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.78300095 11.72200012 Tm [(AP)1(-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.95999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.45999908 11.72200012 Tm [(c-Jun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.52200317 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.52500153 16.35000038 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P05)-1(41)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.52500153 16.35000038 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(06)-1(17)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.52500153 16.35000038 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.52500153 16.35000038 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.52500153 16.35000038 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 100.77500153 0.75 l 100.77500153 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 101.77500153 -0.25 l 101.77500153 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.52500153 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 101.52500153 94.34999847 l h f* Q q 1 0 0 1 101.15000153 0 cm -0.625 -0.25 m 326.0249939 -0.25 l 326.0249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.83999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.33999634 11.72200012 Tm [(put)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.54000092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.04000092 11.72200012 Tm [(tr)1(ansfor)1(m)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.92500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.42500305 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.94099426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.44099426 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.28300476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.78300476 11.72200012 Tm [(avia)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.39700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.89700317 11.72200012 Tm [(sar)1(c)-1(oma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.11700439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.61700439 11.72200012 Tm [(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.88500977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.38500977 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(7.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.44399977 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.94400024 27.3220005 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.94300079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.44300079 27.3220005 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.36000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.86000061 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.83499908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.33499908 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.64199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14199829 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.23899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.73899841 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.30000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.80000305 27.3220005 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.19400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.69400024 27.3220005 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.88900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.38900757 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.46400452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.96400452 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.96499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.46499634 27.3220005 Tm [(viral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.39001465 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.89001465 27.3220005 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.36300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.86300659 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.35400009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.85400009 42.92200089 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.69799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.19799805 42.92200089 Tm [(directly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.91799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.41799927 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.81399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.31399536 42.92200089 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.27099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.77099609 42.92200089 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.75100708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.25100708 42.92200089 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.7559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.2559967 42.92200089 Tm [(seque)-1(nce)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.26901245 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.76901245 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.84399414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.34399414 42.92200089 Tm [(regul)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.43400002 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.93400002 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45000076 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.95000076 58.52199936 Tm [(expression.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.06999969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.56999969 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.83200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.33200073 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.8480072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.3480072 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.90899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.40899658 58.52199936 Tm [(intro)1(n)-1(less)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.24099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.74099731 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.01800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.51800537 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.07899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.57899475 58.52199936 Tm [(map)1(ped)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.3460083 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.8460083 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.92098999 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.42098999 58.52199936 Tm [(1p3)-1(2-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(p31)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.46999931 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.96999931 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.94499969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.44499969 74.12200165 Tm [(chromos)1(omal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.50299835 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.00299835 74.12200165 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.96499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.46499634 74.12200165 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.83399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.33399963 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.2749939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.7749939 74.12200165 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.13900757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.63900757 74.12200165 Tm [(tr)1(ansloc)-1(a)1(tions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.90100098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.40100098 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.67800903 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.17800903 74.12200165 Tm [(dele)-1(t)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ons)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.43400002 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.93400002 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.875 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.375 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.41600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.91600037 89.72200012 Tm [(malignancie)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.28399658 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 0.75 m 101.15000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 17.10000038 m 101.15000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 33.45000076 m 101.15000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 49.80000305 m 101.15000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 66.15000153 m 101.15000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 82.5 m 101.15000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 98.84999847 m 101.15000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 101.15000153 115.19999695 m 101.15000153 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 559.14001465 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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