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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.41799927 23.67700005 Tm 0 g [(ITGB)1(5)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 149.17700195 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.88101196 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(ITGB5)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 80.54399872 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.54400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ITGB5)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 88.41899872 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 90.79299927 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 123.99500275 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 126.3690033 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 186.34899902 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 188.7230072 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 223.19700623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(136-3)1(78)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(ITGB5)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 393.85501099 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 125.52500153 0.75 l 125.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.52500153 -0.25 l 126.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 126.27500153 16.35000038 l h f* Q q 1 0 0 1 125.90000153 0 cm -0.625 -0.25 m 301.2749939 -0.25 l 301.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(integrin,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 35.70100021 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 40.20100021 11.72200012 Tm [(beta)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 59.38299942 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 63.88299942 11.72200012 Tm [(5)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 69.16100311 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 125.52500153 0.75 l 125.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.52500153 -0.25 l 126.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 126.27500153 16.35000038 l h f* Q q 1 0 0 1 125.90000153 0 cm -0.625 -0.25 m 301.2749939 -0.25 l 301.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P18)-1(08)-1(4)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 125.52500153 0.75 l 125.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.52500153 -0.25 l 126.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 126.27500153 16.35000038 l h f* Q q 1 0 0 1 125.90000153 0 cm -0.625 -0.25 m 301.2749939 -0.25 l 301.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(06)-1(54)-1(1)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 125.52500153 0.75 l 125.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.52500153 -0.25 l 126.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 126.27500153 16.35000038 l h f* Q q 1 0 0 1 125.90000153 0 cm -0.625 -0.25 m 301.2749939 -0.25 l 301.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 125.52500153 0.75 l 125.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.52500153 -0.25 l 126.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 126.27500153 16.35000038 l h f* Q q 1 0 0 1 125.90000153 0 cm -0.625 -0.25 m 301.2749939 -0.25 l 301.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 107 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 125.52500153 0.75 l 125.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 126.52500153 -0.25 l 126.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 112 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 126.27500153 16.35000038 l h f* Q q 1 0 0 1 125.90000153 0 cm -0.625 -0.25 m 301.2749939 -0.25 l 301.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 125.52500153 0.75 l 125.52500153 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 126.52500153 -0.25 l 126.52500153 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 125 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 126 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.27500153 0.75 m 426.17498779 0.75 l 426.17498779 172.3500061 l 126.27500153 172.3500061 l h f* Q q 1 0 0 1 125.90000153 0 cm -0.625 -0.25 m 301.2749939 -0.25 l 301.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Integrins)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 37.95100021 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 42.45100021 11.72200012 Tm [(are)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 55.96900177 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 60.46900177 11.72200012 Tm [(heterod)1(ime)-1(rs)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 118.02899933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 122.52899933 11.72200012 Tm [(composed)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 167.69599915 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 172.19599915 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 181.03799438 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 185.53799438 11.72200012 Tm [(nonc)-1(o)1(vale)-1(nt)1(ly)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 245.84399414 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 250.34399414 11.72200012 Tm [(asso)1(c)-1(iat)1(e)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(d)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 5.75699997 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 10.25699997 27.3220005 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 78.51699829 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 83.01699829 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 87.99199677 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 92.49199677 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 108.76899719 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 113.26899719 27.3220005 Tm [(b)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 119.01699829 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 123.51699829 27.3220005 Tm [(subunits.)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 162.14900208 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 166.64900208 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 182.45599365 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 186.95599365 27.3220005 Tm [(16)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 197.51199341 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 202.01199341 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 206.98699951 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 211.48699951 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 227.76400757 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 232.26400757 27.3220005 Tm [(8)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 237.54200745 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 242.04200745 27.3220005 Tm [(b)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 247.78999329 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 252.28999329 27.3220005 Tm [(subunits)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 288.75601196 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(heterod)1(ime)-1(riz)1(e)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 65.31999969 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 69.81999969 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 78.89499664 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 83.39499664 42.92200089 Tm [(pro)1(duc)-1(e)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 119.22399902 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 123.72399902 42.92200089 Tm [(more)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 146.42199707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 150.92199707 42.92200089 Tm [(th)1(an)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 170.33700562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 174.83700562 42.92200089 Tm [(20)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 185.39300537 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 189.89300537 42.92200089 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 226.83299255 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 231.33299255 42.92200089 Tm [(rec)-1(ept)1(ors.)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 274.08700562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 278.58700562 42.92200089 Tm [(Mo)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(st)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 7.51900005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 12.01900005 58.52199936 Tm [(integrin)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 45.55400085 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 50.05400085 58.52199936 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 90.64199829 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 95.14199829 58.52199936 Tm [(bind)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 114.58799744 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 119.08799744 58.52199936 Tm [(ligand)1(s)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 150.07800293 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 154.57800293 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 171.80000305 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 176.30000305 58.52199936 Tm [(are)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 189.81799316 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 194.31799316 58.52199936 Tm [(components)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 248.17300415 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 252.67300415 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 261.51501465 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 266.01501465 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 280.01599121 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 284.51599121 58.52199936 Tm [(e)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(xt)1(race)-1(llular)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 47.0870018 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 51.5870018 74.12200165 Tm [(mat)1(rix,)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 80.90699768 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 85.40699768 74.12200165 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 125.25700378 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 129.75700378 74.12200165 Tm [(Fibronec)-1(t)1(in)-1(,)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 180.46499634 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 184.96499634 74.12200165 Tm [(Collag)1(e)-1(n)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 222.8809967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 227.3809967 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 243.65800476 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 248.15800476 74.12200165 Tm [(Vitronec)-1(t)1(i)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n.)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 7.71199989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 12.21199989 89.72200012 Tm [(Certa)1(i)-1(n)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 43.04399872 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 47.54399872 89.72200012 Tm [(integrins)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 85.24500275 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 89.74500275 89.72200012 Tm [(can)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 104.77899933 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 109.27899933 89.72200012 Tm [(also)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 126.53600311 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 131.03599548 89.72200012 Tm [(bind)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 150.48199463 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 154.98199463 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 164.05700684 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 168.55700684 89.72200012 Tm [(soluble)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 199.63499451 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 204.13499451 89.72200012 Tm [(ligand)1(s)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 235.125 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 239.625 89.72200012 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 259.39199829 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 263.89199829 89.72200012 Tm [(as)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 273.0329895 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 277.5329895 89.72200012 Tm [(Fib)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(rinogen,)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 35.67499924 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 40.17499924 105.3219986 Tm [(or)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 49.33300018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 53.83300018 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 62.90800095 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 67.40799713 105.3219986 Tm [(coun)-1(t)1(e)-1(r)1(re)-1(cepto)1(rs)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 141.21899414 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 145.71899414 105.3219986 Tm [(on)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 156.98699951 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 161.48699951 105.3219986 Tm [(ad)1(jac)-1(ent)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 198.11500549 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 202.61500549 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 221.19099426 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 225.69099426 105.3219986 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 245.45799255 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 249.95799255 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 259.09899902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 263.59899902 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 277.6000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 282.1000061 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(tr)1(ac)-1(ellul)-1(a)1(r)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 42.52600098 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 47.02600098 120.92199707 Tm [(ad)1(hesion)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 86.23400116 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 90.73400116 120.92199707 Tm [(molec)-1(ules)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 134.11700439 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 138.61700439 120.92199707 Tm [(\(ICA)1(M)-1(s)1(\),)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 174.75300598 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 179.25300598 120.92199707 Tm [(leading)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 211.18400574 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 215.68400574 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 224.75900269 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 229.25900269 120.92199707 Tm [(ag)1(gregat)1(ion)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 282.0369873 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 286.5369873 120.92199707 Tm [(o)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(f)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 3.11999989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 7.61999989 136.52200317 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 28.36199951 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 32.86199951 136.52200317 Tm [(Ligands)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 66.0759964 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 70.5759964 136.52200317 Tm [(serve)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 93.11599731 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 97.61599731 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 106.69100189 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 111.19100189 136.52200317 Tm [(cross-)1(l)-1(ink)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 152.32400513 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 156.82400513 136.52200317 Tm [(or)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 165.98199463 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 170.48199463 136.52200317 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 198.9980011 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 203.4980011 136.52200317 Tm [(integrins)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 241.19900513 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 245.69900513 136.52200317 Tm [(by)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 256.21099854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 260.71099854 136.52200317 Tm [(bindin)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(g)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 5.75699997 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 10.25699997 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 19.33200073 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 23.83200073 152.12199402 Tm [(ad)1(jac)-1(ent)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 60.45999908 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 64.95999908 152.12199402 Tm [(integrin)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 98.49500275 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 102.99500275 152.12199402 Tm [(rec)-1(ept)1(ors;)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 145.74899292 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 150.24899292 152.12199402 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 170.61300659 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 175.11300659 152.12199402 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 211.53500366 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 216.03500366 152.12199402 Tm [(cl)-1(ust)1(e)-1(r)1(i)-1(ng)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 258.24899292 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 262.74899292 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 279.02600098 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 283.52600098 152.12199402 Tm [(li)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ga)1(n)-1(d)] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 22.0340004 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 26.5340004 167.72200012 Tm [(occ)-1(upa)1(n)-1(cy)] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 72.3730011 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 76.8730011 167.72200012 Tm [(are)] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 90.39099884 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 94.89099884 167.72200012 Tm [(ne)-1(cessary)] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 136.66999817 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 141.16999817 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 153.44799805 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 157.94799805 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 171.94900513 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 176.44900513 167.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 218.39900208 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 222.89900208 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 231.74099731 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 236.24099731 167.72200012 Tm [(integrin-med)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.90000153 0.75 m 125.90000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.90000153 17.10000038 m 125.90000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.90000153 33.45000076 m 125.90000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.90000153 49.80000305 m 125.90000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.90000153 66.15000153 m 125.90000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.90000153 82.5 m 125.90000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 125.90000153 98.84999847 m 125.90000153 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 270.82501221 m 426.92498779 270.82501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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