%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.3769989 23.67700005 Tm 0 g [(CLEC4D)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.21899414 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 332.92300415 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CL)-1(EC4D)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.64499664 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.64500427 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CL)-1(EC4D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.51999664 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.89399719 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.09599304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.47000122 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.44999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.82400513 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.29800415 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(39-21)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(CL)-1(EC4D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 395.63400269 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.52500153 16.35000038 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C-t)1(ype)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.88500023 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.38499832 11.72200012 Tm [(lec)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.19400024 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.52100372 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.60299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.10299683 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.3809967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.8809967 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64500427 11.72200012 Tm [(D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.5 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.52500153 16.35000038 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(MCL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.59900093 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.09900093 11.72200012 Tm [(MPCL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.20399857 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.70399857 11.72200012 Tm [(CD36)-1(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.58000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.08000183 11.72200012 Tm [(CLEC6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.13200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.63200378 11.72200012 Tm [(CLEC-)1(6)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.07800293 11.72200012 Tm [(CLECSF8)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.10600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.60600281 11.72200012 Tm [(Dec)-1(t)1(in-3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.54600525 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.52500153 16.35000038 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8WXI8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.49900055 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.52500153 16.35000038 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(32)-1(31)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.52500153 16.35000038 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.52500153 16.35000038 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.52500153 16.35000038 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 115.77500153 0.75 l 115.77500153 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 116.77500153 -0.25 l 116.77500153 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.52500153 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 116.52500153 109.94999695 l h f* Q q 1 0 0 1 116.15000153 0 cm -0.625 -0.25 m 311.0249939 -0.25 l 311.0249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(C-t)1(ype)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.16200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.66200256 11.72200012 Tm [(lec)-1(tin/C-t)1(y)-1(p)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.70098877 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.20098877 11.72200012 Tm [(lec)-1(tin-)1(l)-1(ik)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.43299866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.93299866 27.3220005 Tm [(\(CTL/)-1(CTLD\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.24199677 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.74199677 27.3220005 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.99299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.49299622 27.3220005 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.28300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.78300476 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.625 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.125 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.58099365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.08099365 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.16299438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.66299438 27.3220005 Tm [(sha)1(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.88800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.38800049 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.36300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(common)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.36899948 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.86899948 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.1760025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.6760025 42.92200089 Tm [(fo)1(l)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.66999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.16999817 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.4469986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.9469986 42.92200089 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.29400635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.79400635 42.92200089 Tm [(diverse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.48500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.98500061 42.92200089 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.05799866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.55799866 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.32499695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.82499695 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.96600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.46600342 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.87600708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.37600708 42.92200089 Tm [(ad)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(esion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.10199928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.60199928 58.52199936 Tm [(ce)-1(ll-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.31499863 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.81500244 58.52199936 Tm [(signalling,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.30799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.80799866 58.52199936 Tm [(glyc)-1(o)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.26499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.76499939 58.52199936 Tm [(turnov)1(e)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.30200195 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.57899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.07899475 58.52199936 Tm [(roles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.90499878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.40499878 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.3460083 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.8460083 58.52199936 Tm [(inflam)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.42300034 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.92300034 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.20000076 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.70000076 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.15899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.65899658 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.82299805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.32299805 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.58500671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.08500671 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.60099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.10099792 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.66200256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16200256 74.12200165 Tm [(cl)-1(o)1(se)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.2230072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.7230072 74.12200165 Tm [(link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.82199097 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.32199097 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.39700317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.89700317 74.12200165 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.05599976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(CTL/)-1(CTLD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.29700089 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.79700089 89.72200012 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.8809967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.3809967 89.72200012 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.81100464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.31100464 89.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.57899475 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.07899475 89.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.87399292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.37399292 89.72200012 Tm [(12)-1(p13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.23300171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.73300171 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.67401123 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.17401123 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.17498779 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.67498779 89.72200012 Tm [(nat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ural)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.35199928 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.85199928 105.3219986 Tm [(ki)-1(ller)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.47999954 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97999954 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.4960022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.9960022 105.3219986 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.47499847 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.97499847 105.3219986 Tm [(region.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.10400391 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 0.75 m 116.15000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 17.10000038 m 116.15000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 33.45000076 m 116.15000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 49.80000305 m 116.15000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 66.15000153 m 116.15000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 82.5 m 116.15000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 98.84999847 m 116.15000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.15000153 115.19999695 m 116.15000153 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 574.73999023 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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