%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.14499664 23.67700005 Tm 0 g [(CLEC1B)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 155.45100403 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 332.15499878 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CL)-1(EC1B)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 86.89700317 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.89700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CL)-1(EC1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.14600372 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3480072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.72200012 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.70199585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.07600403 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.55000305 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(1-196)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(CL)-1(EC1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.56500244 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C-t)1(ype)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.88500023 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.38499832 11.72200012 Tm [(lec)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.19400024 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.52100372 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.60299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.10299683 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.3809967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.8809967 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64500427 11.72200012 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.29200745 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CLEC2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.05200005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.55199814 11.72200012 Tm [(CLEC2B)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25099945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.75099945 11.72200012 Tm [(PRO138)-1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.74500275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.24500275 11.72200012 Tm [(QDE)1(D7)-1(21;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.73899841 11.72200012 Tm [(18)-1(10)-1(06)-1(1I13)-1(Rik)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.05499268 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9P1)-1(26)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.95199966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(29)-1(55)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 120.27500153 109.94999695 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 307.2749939 -0.25 l 307.2749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Nat)1(ural)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.99699974 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.49700165 11.72200012 Tm [(ki)-1(ller)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.625 11.72200012 Tm [(\(NK\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.66699982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.16699982 11.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.74299622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.24299622 11.72200012 Tm [(express)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.53399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.03399658 11.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.40600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.90600586 11.72200012 Tm [(calc)-1(ium-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.09500122 11.72200012 Tm [(\(C-t)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pe\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.85999966 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.36000061 27.3220005 Tm [(lec)-1(tin-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.35900116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.85900116 27.3220005 Tm [(rec)-1(ept)1(ors,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.61299896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.11299896 27.3220005 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.88000488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.38000488 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.52099609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.02099609 27.3220005 Tm [(CD94)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.45300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.95300293 27.3220005 Tm [(\(KLRD)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.46600342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.96600342 27.3220005 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.19799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.69799805 27.3220005 Tm [(60)-1(28)-1(94)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.3710022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.8710022 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.14801025 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(NKG)1(2)-1(D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.8560009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.35599899 42.92200089 Tm [(\(KLRC4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.03399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.53399658 42.92200089 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.76599884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.26599884 42.92200089 Tm [(60)-1(28)-1(93)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.10499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.60499573 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.82699585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.32699585 42.92200089 Tm [(interact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.00500488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.50500488 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.90100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.40100098 42.92200089 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.3710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.8710022 42.92200089 Tm [(hist)1(ocomp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(ibility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.77199936 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.27199936 58.52199936 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.75099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.25099945 58.52199936 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.46600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.96600342 58.52199936 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.61199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.11199951 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.49499512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.99499512 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.27200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.77200317 58.52199936 Tm [(either)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.71099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.21099854 58.52199936 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.58500671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.08500671 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.24299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.74299622 58.52199936 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.13699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.63699341 58.52199936 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ytot)1(oxicity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.89500046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.39500046 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.67199707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.17199707 74.12200165 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.47100067 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.97100067 74.12200165 Tm [(sec)-1(retio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.48199463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.98199463 74.12200165 Tm [(CLEC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.86799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.36799622 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.92900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.42900085 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.40400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.90400696 74.12200165 Tm [(C-t)1(ype)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.78900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.28900146 74.12200165 Tm [(lec)-1(tin-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.28799438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.78799438 74.12200165 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ce)-1(pt)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.87899971 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.37900162 89.72200012 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.53299713 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.03299713 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.97399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.47399902 89.72200012 Tm [(mye)-1(loid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.04599762 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.54600525 89.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.12199402 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.62199402 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.89900208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.39900208 89.72200012 Tm [(NK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.42900085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.92900085 89.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.50500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.00500488 89.72200012 Tm [(\(Colonna)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.93600464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.43600464 89.72200012 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.89498901 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.39498901 89.72200012 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.09799194 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.59799194 89.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(00)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.83300018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 105.3219986 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.79600143 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.29599762 105.3219986 Tm [(10)-1(67)-1(12)-1(29]\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.6969986 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 0.75 m 119.90000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 17.10000038 m 119.90000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 33.45000076 m 119.90000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 49.80000305 m 119.90000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 66.15000153 m 119.90000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 82.5 m 119.90000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 98.84999847 m 119.90000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 115.19999695 m 119.90000153 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 574.73999023 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>