%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.01100159 23.67700005 Tm 0 g [(CLCA4)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 150.58399963 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.28799438 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CL)-1(CA)1(4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 82.13400269 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 166.13400269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CL)-1(CA)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.00900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.38300323 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.58499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.95899963 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.93899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.31300354 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.78700256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(306-4)1(76)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(CL)-1(CA)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 395.44500732 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 123.07499695 16.35000038 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Calciu)-1(m-)1(activat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.3219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.8219986 11.72200012 Tm [(chloride)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.68800354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.18800354 11.72200012 Tm [(channe)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.81100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.31100464 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.03799438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.53799438 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.81599426 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 123.07499695 16.35000038 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CaCC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.20299911 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.70299911 11.72200012 Tm [(CaCC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.01699829 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 123.07499695 16.35000038 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q14)-1(CN2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.50500107 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 123.07499695 16.35000038 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(13)-1(68)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 123.07499695 16.35000038 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 123.07499695 16.35000038 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 123.07499695 16.35000038 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 122.32499695 0.75 l 122.32499695 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 123.32499695 -0.25 l 123.32499695 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.07499695 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 123.07499695 109.94999695 l h f* Q q 1 0 0 1 122.69999695 0 cm -0.625 -0.25 m 304.4750061 -0.25 l 304.4750061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.04499817 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.11999512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.61999512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.1210022 11.72200012 Tm [(calc)-1(ium)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.89099121 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39099121 11.72200012 Tm [(sensiti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.83100033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.33100033 27.3220005 Tm [(chloride)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.1969986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.6969986 27.3220005 Tm [(conduc)-1(t)1(anc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.78700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.28700256 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.59399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.09399414 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.34199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.84199524 27.3220005 Tm [(To)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.7230072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.2230072 27.3220005 Tm [(da)1(te,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.58000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.08000183 27.3220005 Tm [(all)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.84500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.34500122 27.3220005 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.7749939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.2749939 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.11700439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.47200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97200012 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.05400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.55400085 42.92200089 Tm [(map)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.70999908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.20999908 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.28500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.78500366 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.78600311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.28599548 42.92200089 Tm [(same)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.96600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.46600342 42.92200089 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.48699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.98699951 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.25500488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.75500488 42.92200089 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.55000305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.04998779 42.92200089 Tm [(1p3)-1(1-p)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.05500031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.55500031 58.52199936 Tm [(sha)1(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.77999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.27999878 58.52199936 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.51499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.01499939 58.52199936 Tm [(degrees)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.4509964 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.9509964 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.79299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.29299927 58.52199936 Tm [(ho)1(mology)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.3480072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.8480072 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.78900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.28900146 58.52199936 Tm [(size,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.54800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.04800415 58.52199936 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.89498901 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.39498901 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.67199707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.17199707 58.52199936 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(edic)-1(t)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.98800087 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.48799896 74.12200165 Tm [(st)1(ruc)-1(ture,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.11100006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.61100006 74.12200165 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.25800323 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.75800323 74.12200165 Tm [(dif)1(fe)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.69300079 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.19299316 74.12200165 Tm [(significantly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.51199341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.01199341 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.95300293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.45300293 74.12200165 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.28599548 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.78599548 74.12200165 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.51800537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.01800537 74.12200165 Tm [(dist)1(ributio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.87800026 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37800026 89.72200012 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.10100174 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.60099792 89.72200012 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.51599884 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.01599884 89.72200012 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.18499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.68499756 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.62600708 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.12600708 89.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.4980011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.9980011 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.91999817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.41999817 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.15600586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.65600586 89.72200012 Tm [(only)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.08200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37400055 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.87400055 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.7159996 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.2159996 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.31299973 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81299973 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.37400055 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.87400055 105.3219986 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.68699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.18699646 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.26200104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.76200104 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.61599731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.11599731 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.42300415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.92300415 105.3219986 Tm [(coding.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.77900696 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 0.75 m 122.69999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 17.10000038 m 122.69999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 33.45000076 m 122.69999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 49.80000305 m 122.69999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 66.15000153 m 122.69999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 82.5 m 122.69999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 98.84999847 m 122.69999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.69999695 115.19999695 m 122.69999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 574.73999023 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>