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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.40399933 23.67700005 Tm 0 g [(CHRM2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.19200134 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 332.89599609 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CHRM2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.26599884 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.26600647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CHRM2)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 95.14099884 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 97.51499939 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 130.71699524 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 133.09100342 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 193.07099915 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 195.44500732 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 229.91900635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(208-3)1(88)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(CHRM2)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 400.57699585 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(choline)-1(rg)1(ic)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 47.31999969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 51.81999969 11.72200012 Tm [(rec)-1(ept)1(or,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 90.40799713 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 94.90799713 11.72200012 Tm [(musc)-1(a)1(rini)-1(c)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 140.82600403 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 145.32600403 11.72200012 Tm [(2)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 150.60400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HM2)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 21.03199959 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P08)-1(17)-1(2)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(06)-1(74)-1(2)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 109 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 112 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 117 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 118 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 115.47499847 16.35000038 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 114.72499847 0.75 l 114.72499847 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 115.72499847 -0.25 l 115.72499847 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 131 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 132 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.47499847 0.75 m 426.17501831 0.75 l 426.17501831 156.75 l 115.47499847 156.75 l h f* Q q 1 0 0 1 115.09999847 0 cm -0.625 -0.25 m 312.07501221 -0.25 l 312.07501221 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 133 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(musc)-1(a)1(rini)-1(c)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 66.22499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 70.72499847 11.72200012 Tm [(choline)-1(rg)1(ic)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 118.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 122.54499817 11.72200012 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 163.13299561 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 167.63299561 11.72200012 Tm [(belong)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 197.90699768 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 202.40699768 11.72200012 Tm [(to)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 211.48199463 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 215.98199463 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 220.95700073 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 225.45700073 11.72200012 Tm [(larg)1(e)-1(r)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 250.56300354 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 255.06300354 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 281.14498901 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 285.64498901 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 294.48699951 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(G)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 6.69299984 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 11.19299984 27.3220005 Tm [(pro)1(tein)-1(-)1(c)-1(o)1(u)-1(p)1(le)-1(d)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 81.18000031 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 85.68000031 27.3220005 Tm [(rec)-1(ept)1(ors.)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 128.43400574 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 132.93400574 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 148.74099731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 153.24099731 27.3220005 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 196.35099792 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 200.85099792 27.3220005 Tm [(diversit)1(y)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 236.94799805 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 241.44799805 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 250.28999329 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 254.78999329 27.3220005 Tm [(th)1(e)-1(se)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 278.06298828 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 282.56298828 27.3220005 Tm [(rec)-1(e)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pt)1(ors)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 22.42499924 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 26.92499924 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 33.48600006 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 37.98600006 42.92200089 Tm [(defined)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 70.77400208 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 75.27400208 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 85.78600311 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 90.28600311 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 104.28700256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 108.78700256 42.92200089 Tm [(binding)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 141.93099976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 146.43099976 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 155.272995 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 159.772995 42.92200089 Tm [(ace)-1(t)1(yl)-1(cho)1(l)-1(ine)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 216.0980072 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 220.5980072 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 229.67300415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 234.17300415 42.92200089 Tm [(th)1(e)-1(se)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 257.4460144 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 261.9460144 42.92200089 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 302.53399658 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 16.27700043 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 20.77700043 58.52199936 Tm [(inc)-1(ludes)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 56.20100021 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 60.70100021 58.52199936 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 91.46299744 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 95.96299744 58.52199936 Tm [(responses)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 139.12600708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 143.62600708 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 163.39300537 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 167.89300537 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 177.03399658 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 181.53399658 58.52199936 Tm [(ad)1(e)-1(nylate)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 223.51100159 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 228.01100159 58.52199936 Tm [(cy)-1(clase)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 258.44299316 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 262.94299316 58.52199936 Tm [(inhibit)1(i)-1(o)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n,)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 7.71199989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 12.21199989 74.12200165 Tm [(ph)1(osph)1(oinositide)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 87.23500061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 91.73500061 74.12200165 Tm [(degene)-1(r)1(ation,)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 151.70700073 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 156.20700073 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 172.48399353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 176.98399353 74.12200165 Tm [(po)1(tass)1(i)-1(um)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 221.48699951 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 225.98699951 74.12200165 Tm [(channe)-1(l)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 259.60998535 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 264.10998535 74.12200165 Tm [(mediat)1(i)-1(o)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n.)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 7.71199989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 12.21199989 89.72200012 Tm [(Musc)-1(a)1(rin)-1(ic)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 58.49100113 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 62.99100113 89.72200012 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 103.57900238 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 108.07900238 89.72200012 Tm [(influe)-1(nce)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 147.35299683 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 151.85299683 89.72200012 Tm [(many)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 175.57000732 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 180.07000732 89.72200012 Tm [(effec)-1(t)1(s)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 208.55499268 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 213.05499268 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 221.89700317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 226.39700317 89.72200012 Tm [(ace)-1(t)1(yl)-1(cho)1(l)-1(ine)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 282.72198486 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 287.22198486 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 295.16299438 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 299.66299438 89.72200012 Tm [(t)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(he)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 10.64799976 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 15.14799976 105.3219986 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 44.47299957 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 48.97299957 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 65.25 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 69.75 105.3219986 Tm [(periph)1(e)-1(ra)1(l)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 113.63800049 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 118.13800049 105.3219986 Tm [(ne)-1(r)1(vous)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 152.38499451 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 156.88499451 105.3219986 Tm [(system.)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 189.03999329 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 193.53999329 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 209.34700012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 213.84700012 105.3219986 Tm [(musc)-1(a)1(rini)-1(c)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 259.76501465 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 264.26501465 105.3219986 Tm [(choline)-1(r)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(gic)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 12.66499996 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 17.16500092 120.92199707 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 53.5870018 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 58.0870018 120.92199707 Tm [(2)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 63.36500168 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 67.86499786 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 74.4260025 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 78.9260025 120.92199707 Tm [(involved)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 115.29499817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 119.79499817 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 127.73600006 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 132.23599243 120.92199707 Tm [(mediat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 175.91799927 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 180.41799927 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 189.25999451 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 193.75999451 120.92199707 Tm [(bra)1(dyc)-1(a)1(rdia)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 244.49000549 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 248.99000549 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 265.26699829 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 269.76699829 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 274.74200439 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 279.24200439 120.92199707 Tm [(decre)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ase)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 14.24699974 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 18.74699974 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 26.68799973 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 31.18799973 136.52200317 Tm [(cardiac)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 61.7519989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 66.2519989 136.52200317 Tm [(contractilit)1(y)-1(.)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 119.1309967 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 123.6309967 136.52200317 Tm [(Multiple)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 159.36300659 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 163.86300659 136.52200317 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 216.38600159 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 220.88600159 136.52200317 Tm [(splice)-1(d)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 250.96699524 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 255.46699524 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 296.38900757 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 33.56999969 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 38.06999969 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 58.41699982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 62.91699982 152.12199402 Tm [(been)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 84.4240036 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 88.9240036 152.12199402 Tm [(described)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 130.90899658 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 135.40899658 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 147.68699646 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 152.18699646 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 167.64300537 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 172.14300537 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 195.82499695 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 0.75 m 115.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 17.10000038 m 115.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 33.45000076 m 115.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 49.80000305 m 115.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 66.15000153 m 115.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 82.5 m 115.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 98.84999847 m 115.09999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.09999847 115.19999695 m 115.09999847 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92501831 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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