%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.16699982 23.67700005 Tm 0 g [(CFLAR)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 150.42900085 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.13299561 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CF)-1(LAR)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 81.73899841 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.73899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CF)-1(LAR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.61399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.98799896 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.19000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.56400299 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.54400635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.91799927 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.39199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.20599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.58000183 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.73500061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.10899353 12.55799961 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.07400513 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.44799805 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.32899475 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.70300293 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.20498657 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.57901001 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.32000732 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.69400024 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.66101074 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.03500366 12.55799961 Tm [(CF)-1(LAR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.64898682 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CASP8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.33200073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.83200073 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.10900116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.60900116 11.72200012 Tm [(FADD)1(-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.12400055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.62400055 11.72200012 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.61799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.11799622 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.84500122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 113.92500305 31.95000076 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CASH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.67499924 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.17499924 11.72200012 Tm [(FLIP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.89300156 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.39300156 11.72200012 Tm [(MRIT;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.03299713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.53299713 11.72200012 Tm [(CLARP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.0530014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.5530014 11.72200012 Tm [(FLAME;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.69400024 11.72200012 Tm [(Casp)1(e)-1(r)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.31300354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.81300354 11.72200012 Tm [(FLAME1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.73100281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.23100281 11.72200012 Tm [(c-FL)-1(I)1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.35598755 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.85598755 11.72200012 Tm [(FLAME-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 27.3220005 Tm [(I-FLICE;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.38700104 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.88700104 27.3220005 Tm [(c-FL)-1(I)1(PL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.6309967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.1309967 27.3220005 Tm [(c-FL)-1(I)1(PR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.1309967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.6309967 27.3220005 Tm [(c-FL)-1(I)1(PS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.94999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.44999695 27.3220005 Tm [(CASP8AP)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.897995 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O15)-1(51)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(01)-1(60)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 113.92500305 94.34999847 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 313.625 -0.25 l 313.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.36799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.86799622 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.71000671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.21000671 11.72200012 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.20401001 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.70401001 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.98098755 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 27.3220005 Tm [(st)1(ruc)-1(tura)1(ll)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.93899918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.43899918 27.3220005 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.63400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.13400269 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.20899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.70899963 27.3220005 Tm [(caspa)1(se)-1(-)1(8)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.69599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.19599915 27.3220005 Tm [(However,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.5249939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.0249939 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.02600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.52600098 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.0329895 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.5329895 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.83999634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.33999634 27.3220005 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ack)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.55400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.05400085 42.92200089 Tm [(caspa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.70299911 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.20299911 42.92200089 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.67500305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.17500305 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.45200348 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.95200348 42.92200089 Tm [(ap)1(pears)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.10600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.60600281 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.68099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.18099976 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.03500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.53500366 42.92200089 Tm [(itself)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.07099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.57099915 42.92200089 Tm [(cl)-1(eaved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.147995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.647995 42.92200089 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.66400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.16400146 42.92200089 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.34500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.84500122 42.92200089 Tm [(pep)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tid)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.27700043 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.78900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.28900146 58.52199936 Tm [(caspa)1(se)-1(-)1(8)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.27600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.77600098 58.52199936 Tm [(Se)-1(v)1(e)-1(ra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.71399689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.21399689 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.13600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.63600159 58.52199936 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.20599365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.70599365 58.52199936 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.04800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.54800415 58.52199936 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.48800659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.98800659 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(of)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.59900093 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.09899902 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.44599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.94599915 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.45300293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.95300293 74.12200165 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.64299774 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.14299774 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.42100525 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.92100525 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.3769989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.8769989 74.12200165 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55900574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.05900574 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.33599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.83599854 74.12200165 Tm [(pa)1(rtial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.11300659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.61300659 74.12200165 Tm [(eviden)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.86700439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.36700439 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.64498901 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.14498901 74.12200165 Tm [(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(veral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.63699913 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.13699913 89.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.83499908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.33499908 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.90499878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.40499878 89.72200012 Tm [(exists.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.31999969 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 0.75 m 113.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 17.10000038 m 113.55000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 49.05000305 m 113.55000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 65.40000153 m 113.55000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 81.75 m 113.55000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 98.09999847 m 113.55000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 114.44999695 m 113.55000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 130.80000305 m 113.55000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 574.73999023 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>