%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 65.44200134 23.67700005 Tm 0 g [(CEACAM21)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 173.15400696 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 349.85800171 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CEACAM21)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.22100067 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 187.22099304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CEACAM21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.09600067 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.47000122 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.67199707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.04600525 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.02600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.3999939 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.87399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(35-19)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(CEACAM21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 411.20999146 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.92500305 16.35000038 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(carc)-1(inoembr)1(y)-1(onic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.76399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.26399994 11.72200012 Tm [(antig)1(e)-1(n-)1(re)-1(lat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.46400452 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.87399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.37399292 11.72200012 Tm [(ad)1(hesion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.58200073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.08200073 11.72200012 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.29899597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.79901123 11.72200012 Tm [(21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.35501099 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.92500305 16.35000038 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CEA)1(CAM3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.89199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.39199829 11.72200012 Tm [(R29)-1(12)-1(4_1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.96900177 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.92500305 16.35000038 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q3KPI0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.75499916 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.92500305 16.35000038 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(00)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.92500305 16.35000038 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.92500305 16.35000038 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.92500305 16.35000038 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 110.17500305 0.75 l 110.17500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 111.17500305 -0.25 l 111.17500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.92500305 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 110.92500305 63.15000153 l h f* Q q 1 0 0 1 110.55000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CEA)1(CAM21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.00299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.50299835 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.06399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.56400299 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.53900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.03900146 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.05500031 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.15200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.6519928 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.56900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.06900024 11.72200012 Tm [(carci)-1(noembr)1(y)-1(onic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.83299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.33299255 11.72200012 Tm [(antig)1(e)-1(n.It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.17599487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.67599487 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(longs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.58499908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.08499908 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.15999985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.65999985 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.6609993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.1609993 27.3220005 Tm [(immun)-1(o)1(glob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.73899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.23899841 27.3220005 Tm [(superfa)1(mi)-1(ly-CE)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.51800537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.01800537 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.26600647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.76600647 27.3220005 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.11599731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.61599731 27.3220005 Tm [(isof)1(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.50799942 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.00799942 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.00899887 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.50899887 42.92200089 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.55000305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.05000305 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.35700226 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.85700226 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.375 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.875 42.92200089 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.46000671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.96000671 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.47200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.97200012 42.92200089 Tm [(alt)1(e)-1(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.33700562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.83700562 42.92200089 Tm [(splicin)-1(g)1(.High)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.57299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.07299805 42.92200089 Tm [(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(vels)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.3920002 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.8920002 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.73399925 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.23400116 58.52199936 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.18800354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.68800354 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.6289978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.1289978 58.52199936 Tm [(hemat)1(opoietic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.49200439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.99200439 58.52199936 Tm [(system,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.14700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.64700317 58.52199936 Tm [(bra)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.74699402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.24699402 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.52400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.02400208 58.52199936 Tm [(musc)-1(le.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.3500061 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 0.75 m 110.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 17.10000038 m 110.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 33.45000076 m 110.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 49.80000305 m 110.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 66.15000153 m 110.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 82.5 m 110.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 98.84999847 m 110.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.55000305 115.19999695 m 110.55000305 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 426.92498779 177.9750061 l S Q Q q 1 0 0 1 0 527.94000244 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream 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