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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.78900146 23.67700005 Tm 0 g [(CD)-1(KN)1(1B)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 159.80700684 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 336.51098633 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CDKN)1(1B)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.44999695 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.44999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDKN)1(1B)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 98.32499695 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 100.6989975 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 133.90100098 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 136.2749939 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 196.25500488 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 198.6289978 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 233.10299683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(1-198)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(CDKN)1(1B)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 393.11801147 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.57499695 16.35000038 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cy)-1(clin)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 24.12599945 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 28.62599945 11.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 75.65200043 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 80.15200043 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 107.23999786 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 111.73999786 11.72200012 Tm [(inhibito)1(r)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 148.27200317 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 152.77200317 11.72200012 Tm [(1B)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 163.69700623 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.57499695 16.35000038 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(KIP1;)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 21.30900002 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 25.80900002 11.72200012 Tm [(MEN4;)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 54.31200027 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 58.81200027 11.72200012 Tm [(CDK)1(N4)-1(;)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 92.16200256 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 96.66200256 11.72200012 Tm [(MEN1B)-1(;)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 130.81199646 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 135.31199646 11.72200012 Tm [(P27)-1(K)1(IP1)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 170.51699829 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.57499695 16.35000038 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P46)-1(52)-1(7)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.57499695 16.35000038 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(01)-1(97)-1(1)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 102 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.57499695 16.35000038 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 122 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.57499695 16.35000038 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 123 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 128 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.57499695 16.35000038 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 129 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 123.82499695 0.75 l 123.82499695 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 124.82499695 -0.25 l 124.82499695 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 141 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 142 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.57499695 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 124.57499695 156.75 l h f* Q q 1 0 0 1 124.19999695 0 cm -0.625 -0.25 m 302.9750061 -0.25 l 302.9750061 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 143 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(cy)-1(clin)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 172.71499634 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 177.21499634 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 204.30299377 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 208.80299377 11.72200012 Tm [(inhibito)1(r,)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 247.50100708 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 252.00100708 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 277.09799194 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 281.59799194 11.72200012 Tm [(sh)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ares)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 17.68400002 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 22.18400002 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 27.1590004 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 31.6590004 27.3220005 Tm [(limited)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 61.49300003 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 65.99299622 27.3220005 Tm [(similarit)1(y)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 104.69999695 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 109.19999695 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 127.59600067 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 132.09599304 27.3220005 Tm [(CDK)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 150.68499756 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 155.18499756 27.3220005 Tm [(inhibito)1(r)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 191.71699524 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 196.21699524 27.3220005 Tm [(CDK)1(N1)-1(A)1(/)-1(p)1(2)-1(1.)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 256.04901123 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 260.54901123 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 276.35598755 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 280.85598755 27.3220005 Tm [(en)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(coded)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 26.85499954 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 31.35499954 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 62.66199875 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 67.16200256 42.92200089 Tm [(binds)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 90.77400208 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 95.27400208 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 104.34899902 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 108.84899902 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 125.12599945 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 129.62600708 42.92200089 Tm [(prevents)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 166.81300354 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 171.31300354 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 185.31399536 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 189.81399536 42.92200089 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 231.76400757 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 236.26400757 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 245.10600281 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 249.60600281 42.92200089 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 273.73199463 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 278.23199463 42.92200089 Tm [(E-)1(C)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(DK)1(2)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 17.84600067 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 22.34600067 58.52199936 Tm [(or)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 31.50399971 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 36.00400162 58.52199936 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 60.13000107 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 64.62999725 58.52199936 Tm [(D-)1(CDK4)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 99.2460022 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 103.7460022 58.52199936 Tm [(complexe)-1(s)1(,)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 151.66400146 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 156.16400146 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 172.44099426 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 176.94099426 58.52199936 Tm [(th)1(us)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 195.54699707 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 200.04699707 58.52199936 Tm [(controls)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 234.8999939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 239.3999939 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 253.40100098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 257.90100098 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 272.31100464 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 276.81100464 58.52199936 Tm [(cy)-1(cl)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(pro)1(gression)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 60.80699921 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 65.30699921 74.12200165 Tm [(at)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 73.63500214 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 78.13500214 74.12200165 Tm [(G1.)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 92.27200317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 96.77200317 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 112.57900238 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 117.07900238 74.12200165 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 169.85699463 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 174.35699463 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 183.19900513 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 187.69900513 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 203.15499878 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 207.65499878 74.12200165 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 241.12800598 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 245.62800598 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 270.7250061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 275.2250061 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 281.78601074 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 286.28601074 74.12200165 Tm [(tr)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(igg)1(e)-1(red)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 33.31499863 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 37.81499863 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 48.32699966 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 52.82699966 89.72200012 Tm [(its)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 62.74100113 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 67.24099731 89.72200012 Tm [(CDK)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 85.83000183 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 90.33000183 89.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 137.35600281 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 141.85600281 89.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 212.63000488 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 217.13000488 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 233.40699768 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 237.90699768 89.72200012 Tm [(subsequent)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 287.94799805 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 60.67100143 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 65.17099762 105.3219986 Tm [(by)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 75.68299866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 80.18299866 105.3219986 Tm [(SCF)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 96.17900085 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 100.67900085 105.3219986 Tm [(complexe)-1(s)1(,)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 148.59700012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 153.09700012 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 159.65800476 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 164.15800476 105.3219986 Tm [(required)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 200.69900513 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 205.19900513 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 217.477005 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 221.977005 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 235.97799683 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 240.47799683 105.3219986 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 271.23999023 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 275.73999023 105.3219986 Tm [(tr)1(an)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(sitio)1(n)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 23.57699966 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 28.07699966 120.92199707 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 48.7879982 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 53.2879982 120.92199707 Tm [(quiesc)-1(enc)-1(e)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 101.04299927 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 105.54299927 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 114.61799622 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 119.11799622 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 133.1190033 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 137.6190033 120.92199707 Tm [(pro)1(life)-1(r)1(ative)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 189.53199768 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 194.03199768 120.92199707 Tm [(st)1(ate.)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 217.1519928 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 221.6519928 120.92199707 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 265.50100708 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 270.00100708 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 277.94198608 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 282.44198608 120.92199707 Tm [(th)1(i)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(s)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 4.16599989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 8.66600037 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 30.18199921 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 34.68199921 136.52200317 Tm [(are)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 48.20000076 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 52.70000076 136.52200317 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 97.82700348 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 102.32700348 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 120.72299957 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 125.22299957 136.52200317 Tm [(multiple)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 160.59500122 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 165.09500122 136.52200317 Tm [(en)-1(d)1(ocrin)-1(e)] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 208.2230072 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 212.7230072 136.52200317 Tm [(ne)-1(o)1(plasia)] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 253.75 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 258.25 136.52200317 Tm [(type)] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 277.2210083 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 281.7210083 136.52200317 Tm [(IV)] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 290.45300293 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(\(MEN4\).)] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 34.51499939 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 0.75 m 124.19999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 17.10000038 m 124.19999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 33.45000076 m 124.19999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 49.80000305 m 124.19999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 66.15000153 m 124.19999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 82.5 m 124.19999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 98.84999847 m 124.19999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.19999695 115.19999695 m 124.19999695 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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