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[(CDK6)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 77.95999908 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 161.96000671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDK6)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 85.83499908 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 88.20899963 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 121.41100311 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 123.78500366 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 183.76499939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 186.13900757 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 220.61300659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(13-30)1(0)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(CDK6)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 385.94900513 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cy)-1(clin)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 24.12599945 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 28.62599945 11.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 75.65200043 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 80.15200043 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 107.23999786 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 111.73999786 11.72200012 Tm [(6)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 117.01799774 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(MCPH1)-1(2;)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 40.00299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 44.50299835 11.72200012 Tm [(PLSTIRE)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 78.4509964 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q00)-1(53)-1(4)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(52)-1(26)-1(4)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 114 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 115 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 120 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 133 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 134 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 105.67500305 156.75 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 321.875 -0.25 l 321.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 135 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(CMGC)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 279.7749939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 284.2749939 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 310.35699463 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 84.69599915 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 89.19599915 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 120.50299835 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 125.00299835 27.3220005 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 158.42300415 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 162.92300415 27.3220005 Tm [(This)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 180.18499756 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 184.68499756 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 211.772995 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 216.272995 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 222.83399963 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 227.33399963 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 232.30900574 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 236.80900574 27.3220005 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 272.04400635 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 276.54400635 27.3220005 Tm [(subunit)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 308.84399414 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 27.34300041 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 31.84300041 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 63.15000153 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 67.65000153 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 94.73799896 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 99.23799896 42.92200089 Tm [(complex)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 135.71699524 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 140.21699524 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 157.43899536 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 161.93899536 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 168.5 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 173 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 215.96099854 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 220.46099854 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 232.73899841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 237.23899841 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 251.64900208 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 256.14898682 42.92200089 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 277.44100952 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 281.94100952 42.92200089 Tm [(G1)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 293.9119873 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 298.4119873 42.92200089 Tm [(ph)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ase)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 14.24699974 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 18.74699974 58.52199936 Tm [(pro)1(gression)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 69.94799805 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 74.44799805 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 90.72499847 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 95.22499847 58.52199936 Tm [(G1/S)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 116.23500061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 120.73500061 58.52199936 Tm [(tr)1(ansition.)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 163.78799438 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 168.28799438 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 184.09500122 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 188.59500122 58.52199936 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 219.06700134 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 223.56700134 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 232.40899658 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 236.90899658 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 252.36500549 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 256.86499023 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 283.95300293 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 288.45300293 58.52199936 Tm [(first)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 304.92401123 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ap)1(pears)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 34.15399933 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 38.65399933 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 46.59500122 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 51.09500122 74.12200165 Tm [(mid-)1(G1)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 83.54399872 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 88.04399872 74.12200165 Tm [(ph)1(ase,)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 115.74700165 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 120.24700165 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 145.34399414 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 149.84399414 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 156.40499878 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 160.90499878 74.12200165 Tm [(controlled)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 204.8500061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 209.3500061 74.12200165 Tm [(by)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 219.86199951 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 224.36199951 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 238.36300659 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 242.86300659 74.12200165 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 287.35299683 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 291.85299683 74.12200165 Tm [(subu)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nits)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 15.46000004 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 19.95999908 89.72200012 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 59.81000137 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 64.30999756 89.72200012 Tm [(D-)1(type)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 94.02999878 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 98.52999878 89.72200012 Tm [(cy)-1(clin)-1(s)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 126.8219986 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 131.32200623 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 147.59899902 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 152.09899902 89.72200012 Tm [(members)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 192.52900696 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 197.02900696 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 205.8710022 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 210.3710022 89.72200012 Tm [(INK4)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 231.32400513 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 235.82400513 89.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 261.90600586 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 266.40600586 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 275.24798584 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 279.74798584 89.72200012 Tm [(CDK)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 298.33700562 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 302.83700562 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(hibit)1(ors.)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 34.92300034 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 39.42300034 105.3219986 Tm [(This)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 56.68500137 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 61.18500137 105.3219986 Tm [(ki)-1(na)1(se)-1(,)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 90.43900299 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 94.93900299 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 104.08000183 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 108.58000183 105.3219986 Tm [(well)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 125.58200073 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 130.08200073 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 139.2230072 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 143.7230072 105.3219986 Tm [(CDK)1(4)-1(,)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 169.7559967 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 174.2559967 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 188.93800354 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 193.43800354 105.3219986 Tm [(been)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 214.94500732 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 219.44500732 105.3219986 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 247.52600098 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 252.02600098 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 261.10101318 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 265.60101318 105.3219986 Tm [(ph)1(osph)1(ory)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(lat)1(e)-1(,)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 17.99600029 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 22.49600029 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 38.77299881 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 43.27299881 120.92199707 Tm [(th)1(us)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 61.87900162 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 66.3789978 120.92199707 Tm [(regulat)1(e)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 102.05400085 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 106.55400085 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 120.55500031 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 125.05500031 120.92199707 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 155.5269928 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 160.0269928 120.92199707 Tm [(of)1(,)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 171.03500366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 175.53500366 120.92199707 Tm [(tumor)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 202.0249939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 206.5249939 120.92199707 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 253.76600647 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 258.26599121 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 289.57299805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 294.07299805 120.92199707 Tm [(Rb.)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 307.86300659 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(Alt)1(e)-1(red)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 31.48699951 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 35.98699951 136.52200317 Tm [(expression)] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 81.94100189 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 86.44100189 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 95.28299713 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 99.78299713 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 115.23899841 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 119.73899841 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 141.25500488 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 145.75500488 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 160.43699646 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 164.93699646 136.52200317 Tm [(been)] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 186.44400024 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 190.94400024 136.52200317 Tm [(ob)1(se)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 230.71000671 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 333 >> BDC BT 1 0 0 -1 235.21000671 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 334 >> BDC BT 1 0 0 -1 243.15100098 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 335 >> BDC BT 1 0 0 -1 247.65100098 136.52200317 Tm [(multiple)] TJ ET EMC /P <</MCID 336 >> BDC BT 1 0 0 -1 283.02301025 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 337 >> BDC BT 1 0 0 -1 287.52301025 136.52200317 Tm [(huma)] TJ ET EMC /P <</MCID 338 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <</MCID 339 >> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 340 >> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(canc)-1(ers.)] TJ ET EMC /P <</MCID 341 >> BDC BT 1 0 0 -1 44.4679985 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 342 >> BDC BT 1 0 0 -1 48.9679985 152.12199402 Tm [(A)] TJ ET EMC /P <</MCID 343 >> BDC BT 1 0 0 -1 55.30099869 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 344 >> BDC BT 1 0 0 -1 59.80099869 152.12199402 Tm [(mutat)1(ion)] TJ ET EMC /P <</MCID 345 >> BDC BT 1 0 0 -1 99.1230011 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 346 >> BDC BT 1 0 0 -1 103.6230011 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 347 >> BDC BT 1 0 0 -1 111.56400299 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 348 >> BDC BT 1 0 0 -1 116.06400299 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 349 >> BDC BT 1 0 0 -1 131.52000427 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 350 >> BDC BT 1 0 0 -1 136.02000427 152.12199402 Tm [(gene)] TJ ET EMC /P <</MCID 351 >> BDC BT 1 0 0 -1 157.53599548 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 352 >> BDC BT 1 0 0 -1 162.03599548 152.12199402 Tm [(resulting)] TJ ET EMC /P <</MCID 353 >> BDC BT 1 0 0 -1 199.73699951 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 354 >> BDC BT 1 0 0 -1 204.23699951 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 355 >> BDC BT 1 0 0 -1 212.17799377 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 356 >> BDC BT 1 0 0 -1 216.67799377 152.12199402 Tm [(reduc)-1(ed)] TJ ET EMC /P <</MCID 357 >> BDC BT 1 0 0 -1 251.8999939 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 358 >> BDC BT 1 0 0 -1 256.3999939 152.12199402 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 359 >> BDC BT 1 0 0 -1 270.80999756 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 360 >> BDC BT 1 0 0 -1 275.30999756 152.12199402 Tm [(pro)1(life)-1(r)1(a)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 0.75 m 105.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 17.10000038 m 105.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 33.45000076 m 105.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 49.80000305 m 105.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 66.15000153 m 105.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 82.5 m 105.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 98.84999847 m 105.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 115.19999695 m 105.30000305 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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