%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 4.5 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.83499908 23.67700005 Tm 0 g [(CC)-1(N)1(C)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 146.75999451 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 323.46398926 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CCNC)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 78.6989975 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 162.69900513 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CCNC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.5739975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.94799805 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.15000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.52400208 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.5039978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.87800598 12.82499981 Tm [(Pr)1(o)-1(te)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.65100098 12.82499981 Tm [(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.35099792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(1-283)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(CCNC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.36700439 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.77500153 16.35000038 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cy)-1(clin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.12599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.62599945 11.72200012 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.64699936 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.77500153 16.35000038 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cyc)-1(C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.48399925 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.98399925 11.72200012 Tm [(SRB1)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.42300034 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.92300034 11.72200012 Tm [(hSRB1)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73699951 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.77500153 16.35000038 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P24)-1(86)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.77500153 16.35000038 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(10)-1(13)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.77500153 16.35000038 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.77500153 16.35000038 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.77500153 16.35000038 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 106.02500153 0.75 l 106.02500153 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 107.02500153 -0.25 l 107.02500153 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.77500153 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 106.77500153 94.34999847 l h f* Q q 1 0 0 1 106.40000153 0 cm -0.625 -0.25 m 320.7749939 -0.25 l 320.7749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(cy)-1(clin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.37399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.87399292 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.95599365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.98099899 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.48099899 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.28800201 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.78800201 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.29499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.79499817 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.102005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.602005 27.3220005 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.44599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.94599915 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.34199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.84199524 27.3220005 Tm [(cy)-1(clin)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.88699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.38699341 27.3220005 Tm [(ki)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.24699974 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.74699974 42.92200089 Tm [(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.02499962 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.52499962 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.80199814 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.30199814 42.92200089 Tm [(induc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.33100128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.83100128 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.83200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.33200073 42.92200089 Tm [(ph)1(opho)1(ryl)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.94000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.44000244 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.28199768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.78199768 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.78300476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.28300476 42.92200089 Tm [(carbo)1(xy)-1(-)1(terminal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.53500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.03500366 42.92200089 Tm [(do)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.28300095 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.78300095 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.7840004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.2840004 58.52199936 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.95300293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.45300293 58.52199936 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.75299835 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.25299835 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.09500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.59500122 58.52199936 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.11999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.61999512 58.52199936 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.47200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.97200012 58.52199936 Tm [(II.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.42999268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.92999268 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.73699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.23699951 58.52199936 Tm [(leve)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.96400452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.46400452 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.30599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.80599976 58.52199936 Tm [(mRNA)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.92999268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.42999268 58.52199936 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.11400032 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.61399841 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.13000107 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.63000107 74.12200165 Tm [(peaks)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.52500153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.02500153 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.96600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.46600342 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.46700287 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.96700287 74.12200165 Tm [(G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.93800354 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.43800354 74.12200165 Tm [(ph)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.9750061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.4750061 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.31700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.81700134 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.81799316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.31799316 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.72799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.22799683 74.12200165 Tm [(cy)-1(cle)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.68600464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.18600464 74.12200165 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.17300415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.67300415 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.59500122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.56999969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.06999969 89.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.41200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91200256 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.85199738 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.35199738 89.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.51199341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.01199341 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.35899353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.85899353 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.36599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.86599731 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.55599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.05599976 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.33401489 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.83401489 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.29000854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.79000854 89.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.47198486 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 0.75 m 106.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 17.10000038 m 106.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 33.45000076 m 106.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 49.80000305 m 106.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 66.15000153 m 106.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 82.5 m 106.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 98.84999847 m 106.40000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.40000153 115.19999695 m 106.40000153 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 559.14001465 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>