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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.41699982 23.67700005 Tm 0 g [(CC)-1(N)1(A1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.17900085 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.88299561 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CCNA1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 84.49700165 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.49699402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CCNA1)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 92.37200165 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 94.7460022 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 127.94799805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 130.32200623 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 190.30200195 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 192.67599487 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 227.1499939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(166-4)1(65)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(CCNA1)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 397.80801392 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.27500153 16.35000038 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cy)-1(clin)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 24.12599945 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 28.62599945 11.72200012 Tm [(A1)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 40.23600006 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 73 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.27500153 16.35000038 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CT1)-1(46)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 27.01300049 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.27500153 16.35000038 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P78)-1(39)-1(6)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.27500153 16.35000038 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(36)-1(34)-1(6)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.27500153 16.35000038 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 105 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 108 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.27500153 16.35000038 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 109 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 114 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.27500153 16.35000038 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 115 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 111.52500153 0.75 l 111.52500153 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 112.52500153 -0.25 l 112.52500153 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 128 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.27500153 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 112.27500153 156.75 l h f* Q q 1 0 0 1 111.90000153 0 cm -0.625 -0.25 m 315.2749939 -0.25 l 315.2749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 129 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(belongs)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 193.54499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 198.04499817 11.72200012 Tm [(to)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 207.11999512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 211.61999512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 225.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 230.1210022 11.72200012 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 256.51501465 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 261.01501465 11.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 305.0920105 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 24.12599945 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 28.62599945 27.3220005 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 56.87400055 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 61.37400055 27.3220005 Tm [(wh)1(ose)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 89.01599884 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 93.51599884 27.3220005 Tm [(members)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 133.94599915 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 138.44599915 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 151.96400452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 156.46400452 27.3220005 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 213.99699402 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 218.49699402 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 229.00900269 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 233.50900269 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 238.48399353 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 242.98399353 27.3220005 Tm [(dr)1(amatic)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 280.8210144 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 285.3210144 27.3220005 Tm [(peri)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(od)1(i)-1(city)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 28.89800072 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 33.39799881 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 41.3390007 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 45.8390007 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 77.14600372 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 81.64600372 42.92200089 Tm [(ab)1(u)-1(nd)1(anc)-1(e)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 129.35699463 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 133.85699463 42.92200089 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 168.7539978 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 173.2539978 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 187.25500488 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 191.75500488 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 206.16499329 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 210.66499329 42.92200089 Tm [(cy)-1(cle)-1(.)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 234.1230011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 238.6230011 42.92200089 Tm [(Cyc)-1(lins)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 268.42199707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 272.92199707 42.92200089 Tm [(func)-1(t)1(io)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 19.18700027 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 23.68700027 58.52199936 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 67.58000183 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 72.08000183 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 80.92199707 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 85.42199707 58.52199936 Tm [(CDK)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 104.01100159 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 108.51100159 58.52199936 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 141.93099976 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 146.43099976 58.52199936 Tm [(Diff)1(e)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 184.47000122 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 188.97000122 58.52199936 Tm [(cy)-1(clin)-1(s)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 217.26199341 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 221.76199341 58.52199936 Tm [(exhibit)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 250.86300659 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 255.36300659 58.52199936 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 286.84100342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 291.34100342 58.52199936 Tm [(exp)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ression)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 30.53800011 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 35.0379982 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 51.31499863 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 55.81499863 74.12200165 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 108.59300232 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 113.09300232 74.12200165 Tm [(pa)1(tterns)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 148.7769928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 153.2769928 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 178.37399292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 182.87399292 74.12200165 Tm [(contribut)1(e)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 227.59300232 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 232.09300232 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 241.16799927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 245.66799927 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 259.66900635 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 264.16900635 74.12200165 Tm [(tempo)1(ral)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 303.33700562 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(coord)1(i)-1(na)1(tion)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 55.08100128 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 59.58100128 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 68.42299652 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 72.92299652 89.72200012 Tm [(eac)-1(h)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 93.05899811 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 97.55899811 89.72200012 Tm [(mito)1(tic)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 127.72299957 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 132.2230072 89.72200012 Tm [(eve)-1(nt)1(.)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 158.2250061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 162.7250061 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 178.53199768 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 183.03199768 89.72200012 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 207.15800476 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 211.65800476 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 249.16499329 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 253.66499329 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 264.17700195 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 268.67700195 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 284.13299561 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 288.63299561 89.72200012 Tm [(gen)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 25.85300064 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 30.35300064 105.3219986 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 58.43399811 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 62.93399811 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 72.00900269 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 76.50900269 105.3219986 Tm [(be)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 87.36299896 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 91.86299896 105.3219986 Tm [(expressed)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 135.01699829 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 139.51699829 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 147.45799255 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 151.95799255 105.3219986 Tm [(test)1(i)-1(s)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 174.4980011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 178.9980011 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 195.2749939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 199.7749939 105.3219986 Tm [(bra)1(in)-1(,)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 224.04200745 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 228.54200745 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 237.68299866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 242.18299866 105.3219986 Tm [(well)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 259.18499756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 263.68499756 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 272.82598877 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 277.32598877 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 285.26699829 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 289.76699829 105.3219986 Tm [(sev)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(eral)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 15.91300011 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 20.41300011 120.92199707 Tm [(leu)-1(ke)-1(mic)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 58.80799866 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 63.30799866 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 77.71800232 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 82.21800232 120.92199707 Tm [(line)-1(s,)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 103.99299622 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 108.49299622 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 124.76999664 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 129.27000427 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 135.83099365 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 140.33099365 120.92199707 Tm [(th)1(ought)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 175.14399719 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 179.64399719 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 188.71899414 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 193.21899414 120.92199707 Tm [(prima)1(rily)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 231.19700623 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 235.69700623 120.92199707 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 271.43798828 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 275.93798828 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 283.8789978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 288.3789978 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 302.38000488 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(control)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 30.68700027 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 35.18700027 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 44.02899933 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 48.52899933 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 62.52999878 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 67.02999878 136.52200317 Tm [(germline)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 105.20500183 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 109.70500183 136.52200317 Tm [(mei)-1(o)1(tic)] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 141.62199402 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 146.12199402 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 160.53199768 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 165.03199768 136.52200317 Tm [(cy)-1(cle)-1(.)] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 188.49000549 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 192.99000549 136.52200317 Tm [(This)] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 210.2519989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 214.7519989 136.52200317 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 238.87800598 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 243.37800598 136.52200317 Tm [(binds)] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 266.98999023 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 271.48999023 136.52200317 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 291.85400391 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 296.35400391 136.52200317 Tm [(C)] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(DK)1(2)] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 17.84600067 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 22.34600067 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 38.6230011 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 43.1230011 152.12199402 Tm [(CDC2)] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 67.29699707 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 71.79699707 152.12199402 Tm [(ki)-1(na)1(se)-1(s,)] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 105.21700287 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 333 >> BDC BT 1 0 0 -1 109.71700287 152.12199402 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 334 >> BDC BT 1 0 0 -1 134.81399536 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 335 >> BDC BT 1 0 0 -1 139.31399536 152.12199402 Tm [(give)] TJ ET EMC /P <</MCID 336 >> BDC BT 1 0 0 -1 157.29600525 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 337 >> BDC BT 1 0 0 -1 161.79600525 152.12199402 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 338 >> BDC BT 1 0 0 -1 177.977005 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 339 >> BDC BT 1 0 0 -1 182.477005 152.12199402 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 340 >> BDC BT 1 0 0 -1 213.95500183 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 341 >> BDC BT 1 0 0 -1 218.45500183 152.12199402 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 342 >> BDC BT 1 0 0 -1 245.54299927 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 343 >> BDC BT 1 0 0 -1 250.04299927 152.12199402 Tm [(activit)1(i)-1(es,)] TJ ET EMC /P <</MCID 344 >> BDC BT 1 0 0 -1 289.58499146 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 345 >> BDC BT 1 0 0 -1 294.08499146 152.12199402 Tm [(on)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 0.75 m 111.90000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 17.10000038 m 111.90000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 33.45000076 m 111.90000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 49.80000305 m 111.90000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 66.15000153 m 111.90000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 82.5 m 111.90000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 98.84999847 m 111.90000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.90000153 115.19999695 m 111.90000153 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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