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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.10099792 23.67700005 Tm 0 g [(CC)-1(L)1(21)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 149.4940033 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 326.19799805 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CCL)-1(21)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 81.37999725 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.38000488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CCL)-1(21)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 89.25499725 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 91.6289978 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 124.83100128 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 127.20500183 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 187.18499756 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 189.55900574 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 224.03300476 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(24-13)1(4)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(CCL)-1(21)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 389.36898804 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 116.22499847 16.35000038 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(che)-1(mo)1(k)-1(ine)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 47.26300049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 51.76300049 11.72200012 Tm [(\(C-C)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 70.70300293 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 75.20300293 11.72200012 Tm [(mot)1(if\))] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 101.23200226 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 105.73200226 11.72200012 Tm [(ligand)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 132.55599976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 137.05599976 11.72200012 Tm [(21)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 147.61199951 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 116.22499847 16.35000038 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ECL;)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 17.75399971 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 22.25399971 11.72200012 Tm [(SLC;)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 40.25400162 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 44.75400162 11.72200012 Tm [(CKb)1(9)-1(;)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 69.68000031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 74.18000031 11.72200012 Tm [(TCA4;)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 99.13700104 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 103.63700104 11.72200012 Tm [(6Ck)-1(ine)-1(;)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 135.04899597 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 139.54899597 11.72200012 Tm [(SCYA)1(2)-1(1)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 173.08399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 116.22499847 16.35000038 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O00)-1(58)-1(5)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 97 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 116.22499847 16.35000038 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(27)-1(91)-1(8)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 104 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 116.22499847 16.35000038 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 105 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 124 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 116.22499847 16.35000038 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 125 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 129 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 130 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 116.22499847 16.35000038 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 131 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 115.47499847 0.75 l 115.47499847 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 116.47499847 -0.25 l 116.47499847 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 143 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 144 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.22499847 0.75 m 426.17501831 0.75 l 426.17501831 156.75 l 116.22499847 156.75 l h f* Q q 1 0 0 1 115.84999847 0 cm -0.625 -0.25 m 311.32501221 -0.25 l 311.32501221 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 145 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(one)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 75.21299744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 79.71299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 88.55500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 93.05500031 11.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 122.96399689 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 127.46399689 11.72200012 Tm [(CC)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 139.50500488 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 144.00500488 11.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 180.30400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 184.80400085 11.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 210.48599243 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 214.98599243 11.72200012 Tm [(cl)-1(ust)1(e)-1(r)1(e)-1(d)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 254.36500549 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 258.86499023 11.72200012 Tm [(on)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 270.13299561 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 274.63299561 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 288.63400269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 293.13400269 11.72200012 Tm [(p-)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(arm)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 16.84399986 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 21.34399986 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 30.18600082 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 34.68600082 27.3220005 Tm [(chromos)1(ome)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 91.48100281 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 95.98100281 27.3220005 Tm [(9.)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 103.42500305 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 107.92500305 27.3220005 Tm [(Cytokine)-1(s)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 149.89700317 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 154.39700317 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 167.91499329 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 172.41499329 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 177.38999939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 181.88999939 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 207.97200012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 212.47200012 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 221.31399536 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 225.81399536 27.3220005 Tm [(sec)-1(reted)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 262.35900879 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 266.85900879 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 302.33200073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(involved)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 36.36899948 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 40.86899948 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 48.81000137 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 53.31000137 42.92200089 Tm [(immun)-1(o)1(re)-1(g)1(ulator)1(y)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 133.875 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 138.375 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 154.6519928 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 159.1519928 42.92200089 Tm [(inflammat)1(ory)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 216.69799805 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 221.19799805 42.92200089 Tm [(pro)1(c)-1(esses.)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 265.49499512 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 269.99499512 42.92200089 Tm [(The)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 285.80200195 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 290.30200195 42.92200089 Tm [(CC)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 302.34298706 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(cy)-1(t)1(oki)-1(nes)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 40.46500015 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 44.96500015 58.52199936 Tm [(are)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 58.48300171 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 62.98300171 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 98.45600128 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 102.95600128 58.52199936 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 160.48899841 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 164.98899841 58.52199936 Tm [(by)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 175.50100708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 180.00100708 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 196.18200684 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 200.68200684 58.52199936 Tm [(ad)1(jac)-1(ent)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 237.30999756 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 241.80999756 58.52199936 Tm [(cy)-1(st)1(e)-1(ines.)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 283.0920105 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 287.5920105 58.52199936 Tm [(Si)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(milar)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 21.63400078 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 26.13400078 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 35.20899963 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 39.70899963 74.12200165 Tm [(ot)1(her)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 62.86800003 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 67.36799622 74.12200165 Tm [(che)-1(mo)1(k)-1(ines)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 118.79699707 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 123.29699707 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 137.29800415 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 141.79800415 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 173.10499573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 177.60499573 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 215.11199951 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 219.61199951 74.12200165 Tm [(by)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 230.12399292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 234.62399292 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 250.08000183 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 254.58000183 74.12200165 Tm [(gene)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 276.0960083 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 280.5960083 74.12200165 Tm [(inhib)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(its)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 9.91399956 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 14.41399956 89.72200012 Tm [(hemopo)1(ie)-1(sis)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 68.91500092 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 73.41500092 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 89.69200134 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 94.19200134 89.72200012 Tm [(st)1(i)-1(mulat)1(e)-1(s)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 138.08000183 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 142.58000183 89.72200012 Tm [(che)-1(mo)1(tax)1(i)-1(s)1(.)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 193.51300049 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 198.01300049 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 215.2749939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 219.7749939 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 251.08200073 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 255.58200073 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 262.14300537 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 266.64300537 89.72200012 Tm [(che)-1(mo)1(t)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(actic)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 19.74900055 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 24.24900055 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 32.18999863 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 36.68999863 105.3219986 Tm [(vitr)1(o)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 56.31999969 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 60.81999969 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 73.09799957 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 77.59799957 105.3219986 Tm [(th)1(y)-1(mo)1(c)-1(ytes)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 127.31300354 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 131.81300354 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 148.08999634 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 152.58999634 105.3219986 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 191.74099731 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 196.24099731 105.3219986 Tm [(T)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 201.3999939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 205.8999939 105.3219986 Tm [(ce)-1(lls,)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 226.64199829 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 231.14199829 105.3219986 Tm [(but)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 245.78900146 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 250.28900146 105.3219986 Tm [(not)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 264.91000366 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 269.41000366 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 281.68798828 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 286.18798828 105.3219986 Tm [(B)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 291.83499146 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 296.33499146 105.3219986 Tm [(c)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ell)-1(s,)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 16.22900009 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 20.72900009 120.92199707 Tm [(macrop)1(hages,)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 81.26799774 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 85.76799774 120.92199707 Tm [(or)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 94.9260025 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 99.4260025 120.92199707 Tm [(ne)-1(ut)1(roph)1(il)-1(s)1(.)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 150.54800415 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 155.04800415 120.92199707 Tm [(The)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 170.85499573 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 175.35499573 120.92199707 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 211.65400696 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 216.15400696 120.92199707 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 253.66099548 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 258.16101074 120.92199707 Tm [(by)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 268.67300415 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 273.17300415 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 288.6289978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 293.1289978 120.92199707 Tm [(g)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(en)-1(e)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 15.75899982 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 20.25900078 136.52200317 Tm [(may)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 38.43000031 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 42.93000031 136.52200317 Tm [(also)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 60.18700027 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 64.68699646 136.52200317 Tm [(play)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 82.56800079 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 87.06800079 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 92.04299927 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 96.54299927 136.52200317 Tm [(role)] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 113.20300293 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 117.70300293 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 125.64399719 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 130.14399719 136.52200317 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 173.86099243 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 178.36099243 136.52200317 Tm [(ho)1(mi)-1(ng)] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 211.75500488 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 216.25500488 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 225.09700012 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 229.59700012 136.52200317 Tm [(lymphocytes)] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 284.10198975 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 288.60198975 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 297.67700195 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 333 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(sec)-1(o)1(n)-1(d)1(ary)] TJ ET EMC /P <</MCID 334 >> BDC BT 1 0 0 -1 43.98500061 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 335 >> BDC BT 1 0 0 -1 48.48500061 152.12199402 Tm [(lymphoid)] TJ ET EMC /P <</MCID 336 >> BDC BT 1 0 0 -1 89.23999786 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 337 >> BDC BT 1 0 0 -1 93.73999786 152.12199402 Tm [(org)1(ans.)] TJ ET EMC /P <</MCID 338 >> BDC BT 1 0 0 -1 125.50800323 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 339 >> BDC BT 1 0 0 -1 130.00799561 152.12199402 Tm [(It)] TJ ET EMC /P <</MCID 340 >> BDC BT 1 0 0 -1 136.00700378 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 341 >> BDC BT 1 0 0 -1 140.50700378 152.12199402 Tm [(is)] TJ ET EMC /P <</MCID 342 >> BDC BT 1 0 0 -1 147.06799316 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 343 >> BDC BT 1 0 0 -1 151.56799316 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 344 >> BDC BT 1 0 0 -1 156.54299927 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 345 >> BDC BT 1 0 0 -1 161.04299927 152.12199402 Tm [(hig)1(h)] TJ ET EMC /P <</MCID 346 >> BDC BT 1 0 0 -1 180.27799988 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 347 >> BDC BT 1 0 0 -1 184.77799988 152.12199402 Tm [(af)1(fini)-1(t)1(y)] TJ ET EMC /P <</MCID 348 >> BDC BT 1 0 0 -1 214.44500732 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 349 >> BDC BT 1 0 0 -1 218.94500732 152.12199402 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <</MCID 350 >> BDC BT 1 0 0 -1 262.05499268 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 351 >> BDC BT 1 0 0 -1 266.55499268 152.12199402 Tm [(ligand)] TJ ET EMC /P <</MCID 352 >> BDC BT 1 0 0 -1 293.3789978 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 353 >> BDC BT 1 0 0 -1 297.8789978 152.12199402 Tm [(f)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 0.75 m 115.84999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 17.10000038 m 115.84999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 33.45000076 m 115.84999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 49.80000305 m 115.84999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 66.15000153 m 115.84999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 82.5 m 115.84999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 98.84999847 m 115.84999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.84999847 115.19999695 m 115.84999847 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92501831 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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