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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 81.85600281 23.67700005 Tm 0 g [(CASP14)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.74000549 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 333.44400024 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CASP14)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.69100189 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.69099426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CASP14)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 95.56600189 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 97.94000244 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 131.14199829 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 133.51600647 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 193.4960022 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 195.86999512 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 230.34399414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(6-242)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(CASP14)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 390.35900879 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 130.125 0.75 l 130.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.125 -0.25 l 131.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.875 16.35000038 l h f* Q q 1 0 0 1 130.5 0 cm -0.625 -0.25 m 296.67498779 -0.25 l 296.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(caspa)1(se)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 33.64899826 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 38.14899826 11.72200012 Tm [(14)-1(,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 50.87099838 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 55.37099838 11.72200012 Tm [(ap)1(opt)1(osis-r)1(e)-1(lat)1(e)-1(d)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 131.38800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 135.88800049 11.72200012 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 170.83799744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 175.33799744 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 217.69200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.125 0.75 l 130.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.125 -0.25 l 131.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.875 16.35000038 l h f* Q q 1 0 0 1 130.5 0 cm -0.625 -0.25 m 296.67498779 -0.25 l 296.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P31)-1(94)-1(4)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.125 0.75 l 130.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.125 -0.25 l 131.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.875 16.35000038 l h f* Q q 1 0 0 1 130.5 0 cm -0.625 -0.25 m 296.67498779 -0.25 l 296.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(69)-1(54)-1(1)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.125 0.75 l 130.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.125 -0.25 l 131.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.875 16.35000038 l h f* Q q 1 0 0 1 130.5 0 cm -0.625 -0.25 m 296.67498779 -0.25 l 296.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.125 0.75 l 130.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.125 -0.25 l 131.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 107 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 110 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.875 16.35000038 l h f* Q q 1 0 0 1 130.5 0 cm -0.625 -0.25 m 296.67498779 -0.25 l 296.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.125 0.75 l 130.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.125 -0.25 l 131.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 115 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 116 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.875 16.35000038 l h f* Q q 1 0 0 1 130.5 0 cm -0.625 -0.25 m 296.67498779 -0.25 l 296.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 117 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.125 0.75 l 130.125 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 131.125 -0.25 l 131.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 129 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 130 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.875 0.75 m 426.17498779 0.75 l 426.17498779 172.3500061 l 130.875 172.3500061 l h f* Q q 1 0 0 1 130.5 0 cm -0.625 -0.25 m 296.67498779 -0.25 l 296.67498779 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 131 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(cy)-1(st)1(e)-1(ine-asp)1(art)1(ic)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 242.68099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 247.18099976 11.72200012 Tm [(acid)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 264.8210144 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 269.3210144 11.72200012 Tm [(pro)1(t)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ease)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 19.35400009 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 23.85400009 27.3220005 Tm [(\(caspa)1(se)-1(\))] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 63.51499939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 68.01499939 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 96.26300049 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 100.76300049 27.3220005 Tm [(Se)-1(q)1(ue)-1(ntia)1(l)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 146.13699341 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 150.63699341 27.3220005 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 192.58700562 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 197.08700562 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 205.92900085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 210.42900085 27.3220005 Tm [(caspa)1(se)-1(s)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 248.2440033 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 252.7440033 27.3220005 Tm [(plays)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 274.79098511 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 279.29098511 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 284.26599121 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 29.32500076 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 33.82500076 42.92200089 Tm [(role)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 50.48500061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 54.98500061 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 62.92599869 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 67.4260025 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 81.42700195 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 85.92700195 42.92200089 Tm [(exe)-1(cution-p)1(hase)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 157.20599365 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 161.70599365 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 170.54800415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 175.04800415 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 189.45799255 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 193.95799255 42.92200089 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 238.1190033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 242.6190033 42.92200089 Tm [(Casp)1(ases)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 281.94100952 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(exist)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 19.58200073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 24.08200073 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 33.22299957 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 37.72299957 58.52199936 Tm [(inac)-1(t)1(ive)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 70.73000336 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 75.23000336 58.52199936 Tm [(pro)1(e)-1(nzymes)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 127.68299866 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 132.18299866 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 157.27999878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 161.77999878 58.52199936 Tm [(undergo)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 198.6499939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 203.1499939 58.52199936 Tm [(pro)1(teolytic)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 249.65699768 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 254.15699768 58.52199936 Tm [(pro)1(c)-1(ess)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ing)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 13.69799995 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 18.19799995 74.12200165 Tm [(at)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 26.52599907 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 31.02599907 74.12200165 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 75.10299683 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 79.60299683 74.12200165 Tm [(asp)1(art)1(i)-1(c)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 113.16400146 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 117.66400146 74.12200165 Tm [(residues)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 153.34300232 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 157.84300232 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 166.91799927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 171.41799927 74.12200165 Tm [(pro)1(duc)-1(e)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 207.24699402 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 211.74699402 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 227.92799377 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 232.42799377 74.12200165 Tm [(subunits,)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 271.05999756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 275.55999756 74.12200165 Tm [(lar)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ge)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 31.63999939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 36.13999939 89.72200012 Tm [(small,)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 60.66999817 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 65.16999817 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 82.39199829 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 86.89199829 89.72200012 Tm [(dimerize)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 123.9469986 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 128.44700623 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 137.52200317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 142.02200317 89.72200012 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 162.73300171 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 167.23300171 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 181.23399353 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 185.73399353 89.72200012 Tm [(active)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 210.80000305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 215.30000305 89.72200012 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 250.84700012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 255.34700012 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 272.60900879 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 277.10900879 89.72200012 Tm [(ca)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(spa)1(se)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 24.1609993 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 28.6609993 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 43.3429985 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 47.8429985 105.3219986 Tm [(been)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 69.34999847 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 73.84999847 105.3219986 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 101.93099976 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 106.43099976 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 115.5059967 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 120.0059967 105.3219986 Tm [(be)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 130.86000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 135.36000061 105.3219986 Tm [(pro)1(c)-1(essed)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 179.08099365 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 183.58099365 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 199.85800171 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 204.35800171 105.3219986 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 243.50900269 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 248.00900269 105.3219986 Tm [(by)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 258.52099609 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 263.02099609 105.3219986 Tm [(caspa)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(se)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 9.27200031 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 13.77200031 120.92199707 Tm [(8)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 19.04999924 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 23.54999924 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 39.82699966 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 44.32699966 120.92199707 Tm [(caspa)1(se)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 77.97599792 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 82.47599792 120.92199707 Tm [(10)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 93.03199768 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 97.53199768 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 105.47299957 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 109.97299957 120.92199707 Tm [(vitr)1(o,)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 131.77000427 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 136.27000427 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 152.54699707 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 157.04699707 120.92199707 Tm [(by)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 167.55900574 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 172.05900574 120.92199707 Tm [(anti-)1(Fas)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 206.14300537 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 210.64300537 120.92199707 Tm [(ag)1(onist)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 242.55599976 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 247.05599976 120.92199707 Tm [(antib)1(ody)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 285.31500244 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(or)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 9.15799999 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 13.65799999 136.52200317 Tm [(TNF-related)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 64.93800354 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 69.43800354 136.52200317 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 111.43199921 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 115.93199921 136.52200317 Tm [(induc)-1(ing)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 153.38699341 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 157.88699341 136.52200317 Tm [(ligand)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 184.71099854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 189.21099854 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 197.1519928 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 201.6519928 136.52200317 Tm [(vivo.)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 221.38299561 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 225.88299561 136.52200317 Tm [(The)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 241.69000244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 246.19000244 136.52200317 Tm [(expressio)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 26.32299995 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 30.82299995 152.12199402 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 77.3789978 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 81.8789978 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 90.72100067 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 95.22100067 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 110.67700195 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 115.17700195 152.12199402 Tm [(caspa)1(se)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 148.82600403 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 153.32600403 152.12199402 Tm [(may)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 171.49699402 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 175.99699402 152.12199402 Tm [(be)] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 186.85099792 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 191.35099792 152.12199402 Tm [(involved)] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 227.72000122 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 232.22000122 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 240.16099548 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 244.66099548 152.12199402 Tm [(ke)-1(ra)1(tinoc)] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(yte)] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 13.22299957 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 17.72299957 167.72200012 Tm [(terminal)] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 53.36299896 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 57.86299896 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion,)] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 121.35500336 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 125.85500336 167.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 333 >> BDC BT 1 0 0 -1 150.95199585 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 334 >> BDC BT 1 0 0 -1 155.45199585 167.72200012 Tm [(is)] TJ ET EMC /P <</MCID 335 >> BDC BT 1 0 0 -1 162.01300049 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 336 >> BDC BT 1 0 0 -1 166.51300049 167.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 337 >> BDC BT 1 0 0 -1 209.47399902 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 338 >> BDC BT 1 0 0 -1 213.97399902 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 339 >> BDC BT 1 0 0 -1 226.2519989 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 340 >> BDC BT 1 0 0 -1 230.7519989 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 341 >> BDC BT 1 0 0 -1 244.75300598 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 342 >> BDC BT 1 0 0 -1 249.25300598 167.72200012 Tm [(fo)1(rmatio)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.5 0.75 m 130.5 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.5 17.10000038 m 130.5 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.5 33.45000076 m 130.5 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.5 49.80000305 m 130.5 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.5 66.15000153 m 130.5 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.5 82.5 m 130.5 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.5 98.84999847 m 130.5 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 270.82501221 m 426.92498779 270.82501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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