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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.43099976 23.67700005 Tm 0 g [(CASP3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.16400146 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.86801147 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CASP3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 82.37000275 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 166.36999512 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CASP3)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 90.24500275 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 92.6190033 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 125.82099915 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 128.19500732 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 188.17500305 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 190.54899597 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 225.022995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(N)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 146.20599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 148.58000183 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 184.73500061 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 187.10899353 12.55799961 Tm [(269)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 203.07400513 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 205.44799805 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 232.32899475 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 234.70300293 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 256.20498657 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 258.57901001 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 267.32000732 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 269.69400024 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 299.66101074 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 302.03500366 12.55799961 Tm [(CASP3)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 329.27999878 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 61 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.82499695 16.35000038 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 65 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(caspa)1(se)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 33.64899826 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 38.14899826 11.72200012 Tm [(3,)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 45.5929985 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 50.0929985 11.72200012 Tm [(ap)1(opt)1(osis-r)1(e)-1(lat)1(e)-1(d)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 126.11000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 130.61000061 11.72200012 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 165.55999756 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 170.05999756 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 212.41400146 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.82499695 16.35000038 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CPP32,)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 29.75499916 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 34.25500107 11.72200012 Tm [(SCA-)1(1)-1(,)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63.13999939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 67.63999939 11.72200012 Tm [(CPP32B)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 100.87599945 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.82499695 16.35000038 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P42)-1(57)-1(4)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.82499695 16.35000038 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(16)-1(92)-1(6)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.82499695 16.35000038 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 114 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.82499695 16.35000038 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 115 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 120 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 106.82499695 16.35000038 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 106.07499695 0.75 l 106.07499695 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 107.07499695 -0.25 l 107.07499695 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 133 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 134 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 106.82499695 0.75 m 426.17498779 0.75 l 426.17498779 156.75 l 106.82499695 156.75 l h f* Q q 1 0 0 1 106.44999695 0 cm -0.625 -0.25 m 320.7250061 -0.25 l 320.7250061 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 135 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 158.57400513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 163.07400513 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 169.63499451 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 174.13499451 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 179.11000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 183.61000061 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 219.87399292 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 224.37399292 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 233.21600342 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 237.71600342 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 251.71699524 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 256.2170105 11.72200012 Tm [(cy)-1(st)1(e)-1(ine-asp)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(art)1(ic)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 18.67200089 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 23.17200089 27.3220005 Tm [(acid)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 40.81200027 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 45.31200027 27.3220005 Tm [(pro)1(tease)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 82.92500305 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 87.42500305 27.3220005 Tm [(\(caspa)1(se)-1(\))] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 127.08599854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 131.58599854 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 159.83399963 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 164.33399963 27.3220005 Tm [(Se)-1(q)1(ue)-1(ntia)1(l)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 209.70799255 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 214.20799255 27.3220005 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 256.1579895 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 260.6579895 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 269.5 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 274 27.3220005 Tm [(caspa)1(se)-1(s)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 311.81500244 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(plays)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 22.04700089 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 26.54700089 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 31.52199936 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 36.02199936 42.92200089 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 65.34700012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 69.84700012 42.92200089 Tm [(role)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 86.50700378 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 91.00700378 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 98.94799805 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 103.44799805 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 117.4489975 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 121.9489975 42.92200089 Tm [(exe)-1(cution-p)1(hase)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 193.22799683 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 197.72799683 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 206.57000732 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 211.07000732 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 225.47999573 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 229.97999573 42.92200089 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 274.14099121 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 278.64099121 42.92200089 Tm [(Casp)1(as)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(es)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 9.27200031 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 13.77200031 58.52199936 Tm [(exist)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 33.35400009 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 37.85400009 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 46.99499893 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 51.49499893 58.52199936 Tm [(inac)-1(t)1(ive)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 84.5019989 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 89.0019989 58.52199936 Tm [(pro)1(e)-1(nzymes)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 141.45500183 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 145.95500183 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 171.05200195 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 175.55200195 58.52199936 Tm [(undergo)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 212.42199707 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 216.92199707 58.52199936 Tm [(pro)1(teolytic)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 263.4289856 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 267.9289856 58.52199936 Tm [(pro)1(c)-1(essin)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(g)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(at)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 18.58499908 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 23.08499908 74.12200165 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 67.16200256 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 71.66200256 74.12200165 Tm [(asp)1(art)1(i)-1(c)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 105.22299957 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 109.72299957 74.12200165 Tm [(residues)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 145.4019928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 149.9019928 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 158.977005 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 163.477005 74.12200165 Tm [(pro)1(duc)-1(e)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 199.30599976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 203.80599976 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 219.98699951 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 224.48699951 74.12200165 Tm [(subunits,)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 263.11898804 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 267.61898804 74.12200165 Tm [(larg)1(e)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 289.28799438 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 293.78799438 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 310.06500244 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(small,)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 24.53000069 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 29.03000069 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 46.2519989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 50.7519989 89.72200012 Tm [(dimerize)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 87.80699921 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 92.30699921 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 101.38200378 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 105.88200378 89.72200012 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 126.59300232 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 131.09300232 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 145.09399414 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 149.59399414 89.72200012 Tm [(active)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 174.66000366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 179.16000366 89.72200012 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 214.70700073 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 219.20700073 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 236.46899414 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 240.96899414 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 272.27600098 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 276.77600098 89.72200012 Tm [(cl)-1(eaves)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 307.76199341 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 16.27700043 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 20.77700043 105.3219986 Tm [(activat)1(es)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 58.3370018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 62.8370018 105.3219986 Tm [(caspa)1(se)-1(s)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 100.65200043 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 105.15200043 105.3219986 Tm [(6,)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 112.59600067 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 117.09600067 105.3219986 Tm [(7)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 122.37400055 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 126.87400055 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 143.15100098 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 147.65100098 105.3219986 Tm [(9,)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 155.09500122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 159.59500122 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 175.87199402 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 180.37199402 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 194.3730011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 198.8730011 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 230.17999268 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 234.67999268 105.3219986 Tm [(itself)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 255.21600342 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 259.71600342 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 266.27700806 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 270.77700806 105.3219986 Tm [(pro)1(c)-1(esse)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(d)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(by)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 20.7689991 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 25.2689991 120.92199707 Tm [(caspa)1(se)-1(s)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 63.08399963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 67.58399963 120.92199707 Tm [(8,)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 75.02799988 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 79.52799988 120.92199707 Tm [(9)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 84.80599976 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 89.30599976 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 105.58300018 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 110.08300018 120.92199707 Tm [(10)-1(.)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 122.80500031 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 127.30500031 120.92199707 Tm [(It)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 133.30400085 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 137.80400085 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 144.36500549 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 148.86500549 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 162.86599731 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 167.36599731 120.92199707 Tm [(predo)1(min)-1(a)1(n)-1(t)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 223.38299561 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 227.88299561 120.92199707 Tm [(caspa)1(se)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 261.53201294 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 266.03201294 120.92199707 Tm [(involved)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 302.40100098 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 306.90100098 120.92199707 Tm [(i)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(n)] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 5.546 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 10.04599953 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 24.04700089 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 28.54700089 136.52200317 Tm [(cl)-1(eava)1(ge)] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 66.09799957 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 70.59799957 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 79.44000244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 83.94000244 136.52200317 Tm [(amyloid-)1(beta)] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 141.45599365 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 145.95599365 136.52200317 Tm [(4A)] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 157.56599426 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 162.06599426 136.52200317 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 203.17700195 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 207.67700195 136.52200317 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 241.1499939 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 245.6499939 136.52200317 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 270.74700928 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 275.24700928 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 281.80801392 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 286.30801392 136.52200317 Tm [(asso)1(c)-1(i)] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(at)1(e)-1(d)] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 19.19099998 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 333 >> BDC BT 1 0 0 -1 23.69099998 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 334 >> BDC BT 1 0 0 -1 42.0870018 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 335 >> BDC BT 1 0 0 -1 46.5870018 152.12199402 Tm [(ne)-1(uro)1(n)-1(a)1(l)] TJ ET EMC /P <</MCID 336 >> BDC BT 1 0 0 -1 84.85900116 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 337 >> BDC BT 1 0 0 -1 89.35900116 152.12199402 Tm [(deat)1(h)] TJ ET EMC /P <</MCID 338 >> BDC BT 1 0 0 -1 114.09100342 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 339 >> BDC BT 1 0 0 -1 118.59100342 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 340 >> BDC BT 1 0 0 -1 126.53199768 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 341 >> BDC BT 1 0 0 -1 131.03199768 152.12199402 Tm [(Alz)1(he)-1(imer's)] TJ ET EMC /P <</MCID 342 >> BDC BT 1 0 0 -1 180.67700195 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 343 >> BDC BT 1 0 0 -1 185.17700195 152.12199402 Tm [(disease.)] TJ ET EMC /P <</MCID 344 >> BDC BT 1 0 0 -1 219.01499939 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 345 >> BDC BT 1 0 0 -1 223.51499939 152.12199402 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 346 >> BDC BT 1 0 0 -1 270.23800659 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 347 >> BDC BT 1 0 0 -1 274.73800659 152.12199402 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 348 >> BDC BT 1 0 0 -1 307.65301514 152.12199402 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 0.75 m 106.44999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 17.10000038 m 106.44999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 33.45000076 m 106.44999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 49.80000305 m 106.44999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 66.15000153 m 106.44999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 82.5 m 106.44999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 98.84999847 m 106.44999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.44999695 115.19999695 m 106.44999695 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 271.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 271.57501221 m 426.92498779 271.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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