%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 106 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.38500214 23.67700005 Tm 0 g [(CAPN5)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.21099854 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.91500854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CAP)1(N5)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 84.32299805 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.32299805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CAP)1(N5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.19799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5719986 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.147995 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.12800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.5019989 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.97599792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(344-4)1(96)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(CAP)1(N5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 397.63400269 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.77500153 16.35000038 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(calpain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.54599953 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.04600143 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.32400131 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.77500153 16.35000038 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(VRNI;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.0909996 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.5909996 11.72200012 Tm [(AD)1(NIV)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.99399948 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.4940033 11.72200012 Tm [(HT)-1(RA)1(3)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.26599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.76599884 11.72200012 Tm [(nCL-3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.12200165 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.77500153 16.35000038 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O15)-1(48)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.77500153 16.35000038 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(18)-1(12)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.77500153 16.35000038 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.77500153 16.35000038 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.77500153 16.35000038 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 120.02500153 0.75 l 120.02500153 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 121.02500153 -0.25 l 121.02500153 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.77500153 0.75 m 426.17498779 0.75 l 426.17498779 125.55000305 l 120.77500153 125.55000305 l h f* Q q 1 0 0 1 120.40000153 0 cm -0.625 -0.25 m 306.7749939 -0.25 l 306.7749939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Calp)1(ain)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.22000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.72000122 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.23799896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.73799896 11.72200012 Tm [(calc)-1(ium-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.42700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.92700195 11.72200012 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.8769989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.3769989 11.72200012 Tm [(pro)1(teases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.15600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.65600586 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.0249939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.5249939 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.46600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.96600342 11.72200012 Tm [(sig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.91600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.41600037 27.3220005 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.72399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.22399902 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.16500092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66500092 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.63999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.13999939 27.3220005 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.89299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.39300537 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.73500061 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.49699402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.99699402 27.3220005 Tm [(pro)1(c)-1(esses.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.29400635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.79400635 27.3220005 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.1269989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.6269989 27.3220005 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.73699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.23699951 27.3220005 Tm [(ca)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(lpain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.05900002 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.55900002 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.86600113 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.36600113 42.92200089 Tm [(consists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.39299774 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.89299774 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.73500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.23500061 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.7559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.2559967 42.92200089 Tm [(invariant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.60099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.10099792 42.92200089 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.46499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.96499634 42.92200089 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.26499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.76499939 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.04200745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.54200745 42.92200089 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.82000732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.32000732 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.1619873 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.6619873 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.63699341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.13699341 42.92200089 Tm [(fa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.98699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.48699951 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.32900047 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.82899857 58.52199936 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.4980011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.9980011 58.52199936 Tm [(subunits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.62999725 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.12999725 58.52199936 Tm [(CAP)1(N5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.58399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.08399963 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.64500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.14500427 58.52199936 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.51899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.01899719 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.86099243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.36099243 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.36199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.86199951 58.52199936 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.53100586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.03100586 58.52199936 Tm [(subunits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.66299438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.16299438 58.52199936 Tm [(Unlik)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.03300095 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.53300095 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.375 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.875 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.87599945 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.37599945 74.12200165 Tm [(calpains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.25499725 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.75499725 74.12200165 Tm [(CAP)1(N5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.20899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.70899963 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.98599243 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.48599243 74.12200165 Tm [(CAP)1(N6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.94000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.44000244 74.12200165 Tm [(lack)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.2230072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.7230072 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.69799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.19799805 74.12200165 Tm [(calmodulin-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.56399536 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.82699966 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.32699966 89.72200012 Tm [(IV.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.22499847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.72499847 89.72200012 Tm [(Be)-1(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.78500366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.28500366 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.1269989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6269989 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.62799835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.12799835 89.72200012 Tm [(significant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.28900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.78900146 89.72200012 Tm [(similarit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.4960022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.9960022 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.07099915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.57099915 89.72200012 Tm [(Caenorha)1(bdit)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.70700073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ele)-1(ga)1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.05099869 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.55099869 105.3219986 Tm [(sex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.38499832 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.88499832 105.3219986 Tm [(determinat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.00900269 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.50900269 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.0249939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.5249939 105.3219986 Tm [(tr)1(a-3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.6269989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.1269989 105.3219986 Tm [(CAP)1(N5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.58099365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.08099365 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.64199829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.14199829 105.3219986 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.39900208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.89900208 105.3219986 Tm [(calle)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.04000854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.54000854 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.68099976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.18099976 105.3219986 Tm [(HT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(RA)1(3)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.65200043 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 0.75 m 120.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 17.10000038 m 120.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 33.45000076 m 120.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 49.80000305 m 120.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 66.15000153 m 120.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 82.5 m 120.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 98.84999847 m 120.40000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.40000153 115.19999695 m 120.40000153 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 240.375 m 426.92498779 240.375 l S Q Q q 1 0 0 1 0 590.34002686 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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