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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.38500214 23.67700005 Tm 0 g [(CAPN1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.21099854 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.91500854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CAP)1(N1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 84.32299805 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.32299805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CAP)1(N1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.19799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5719986 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.147995 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.12800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.5019989 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.97599792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(543-7)1(13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(CAP)1(N1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 397.63400269 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(calpain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.54599953 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.04600143 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.32400131 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CANP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 11.72200012 Tm [(muCL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.62799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.12799835 11.72200012 Tm [(CANP)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.74900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.24900055 11.72200012 Tm [(SPG76;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.36500549 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.86500549 11.72200012 Tm [(CANP)1(L)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.10400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.60400391 11.72200012 Tm [(muCANP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.75900269 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P07)-1(38)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(17)-1(20)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 125.55000305 l 109.42500305 125.55000305 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(calpains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.18600082 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.68600082 11.72200012 Tm [(calc)-1(ium-a)1(c)-1(t)1(i)-1(va)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.5 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142 11.72200012 Tm [(ne)-1(ut)1(ral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.35699463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.85699463 11.72200012 Tm [(pro)1(teases,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.80200195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.30200195 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.82000732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.32000732 11.72200012 Tm [(nonly)-1(s)1(osomal,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.0369873 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.46699905 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.96699905 27.3220005 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.91699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.41699982 27.3220005 Tm [(pro)1(teases.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.36199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.86199951 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.66900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.16900635 27.3220005 Tm [(mammalia)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.72799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.22799683 27.3220005 Tm [(calpains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.94000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.44000244 27.3220005 Tm [(inc)-1(lude)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.19799805 27.3220005 Tm [(ubi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(quito)1(us,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.65100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.15100098 42.92200089 Tm [(st)1(omach-sp)1(e)-1(cific)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.8710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.3710022 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.647995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.147995 42.92200089 Tm [(musc)-1(le-sp)1(e)-1(cific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.15800476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.65800476 42.92200089 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.29699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.79699707 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.60400391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.10400391 42.92200089 Tm [(ubiquito)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.71199989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.21199989 58.52199936 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.75899887 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.25899887 58.52199936 Tm [(consist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.12000275 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.62000275 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.46199799 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.96199799 58.52199936 Tm [(heterod)1(ime)-1(rs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.52200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.02200317 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.41799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.91799927 58.52199936 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.39599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.89599609 58.52199936 Tm [(larg)1(e)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.73199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.23199463 58.52199936 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.4670105 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.9670105 58.52199936 Tm [(sub)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(uni)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.00600052 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.50600052 74.12200165 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.63300323 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.13300323 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.52899933 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.02899933 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.0039978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.5039978 74.12200165 Tm [(common)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.8730011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.3730011 74.12200165 Tm [(small,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.90299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.40299988 74.12200165 Tm [(regulat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.39300537 74.12200165 Tm [(subunit.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.85900879 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.35900879 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.6210022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.1210022 74.12200165 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 89.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.52299881 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.02299881 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.02400208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.52400208 89.72200012 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.19300079 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.69300079 89.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.99299622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.49299622 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.33500671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.83500671 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.83599854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.33599854 89.72200012 Tm [(ubiquito)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.50900269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.00900269 89.72200012 Tm [(en)-1(z)1(y)-1(me,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.55599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.05599976 89.72200012 Tm [(calpain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.60198975 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.10198975 89.72200012 Tm [(1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.54598999 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.04598999 89.72200012 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(eve)-1(ra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.74300003 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.24300003 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.16500092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.66500092 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.23500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.73500061 105.3219986 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.07699585 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.57699585 105.3219986 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.75799561 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.25799561 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.19799805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.69799805 105.3219986 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.85800171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.35800171 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.70498657 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.20498657 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.71200562 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.69000053 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.19000053 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.4679985 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.9679985 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.42399979 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.9240036 120.92199707 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.60600281 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 0.75 m 109.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 17.10000038 m 109.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 33.45000076 m 109.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 49.80000305 m 109.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 66.15000153 m 109.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 82.5 m 109.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 98.84999847 m 109.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 115.19999695 m 109.05000305 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 240.375 m 426.92498779 240.375 l S Q Q q 1 0 0 1 0 590.34002686 cm Q Q 1 0 0 -1 0 841.90002441 cm
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