%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.31999969 23.67700005 Tm 0 g [(RMND5A)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 164.2749939 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.97900391 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(RMN)1(D)-1(5A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.81300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.06300354 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.06300354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RMN)1(D)-1(5A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.31300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.68699646 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.88900757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.26300049 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.24299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.61700439 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.09100342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(re)1(q)-1(uired)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.72899628 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.01699829 12.82499981 Tm [(fo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.41899872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.70700073 12.82499981 Tm [(me)1(i)-1(oti)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.63299561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.92100525 12.82499981 Tm [(nu)-1(clear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.71800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.0059967 12.82499981 Tm [(di)-1(visi)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.65400696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.94200134 12.82499981 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.26400757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.55200195 12.82499981 Tm [(ho)-1(molo)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.42001343 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.70800781 12.82499981 Tm [(A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.59298706 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.88101196 12.82499981 Tm [(CT)-1(LH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.6499939 12.82499981 Tm [(GID2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.51098633 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 351.79901123 12.82499981 Tm [(RMD5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.06900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.35699463 12.82499981 Tm [(GID2A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(p44CT)-1(LH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.83200073 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 288.31201172 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 47.37799835 l -0.75 47.37799835 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 33.98099899 1.25 l 33.98099899 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 33.98099899 1.25 m 65.28799438 1.25 l 65.28799438 16.68799973 l 33.98099899 16.68799973 l h f* Q q /GS2 gs 1 g 65.28800201 1.25 m 71.11299896 1.25 l 71.11299896 16.68799973 l 65.28800201 16.68799973 l h f* Q q /GS2 gs 1 g 71.11299896 1.25 m 133.96400452 1.25 l 133.96400452 16.68799973 l 71.11299896 16.68799973 l h f* Q q /GS2 gs 1 g 133.96400452 1.25 m 139.78900146 1.25 l 139.78900146 16.68799973 l 133.96400452 16.68799973 l h f* Q q /GS2 gs 1 g 139.78900146 1.25 m 148.86399841 1.25 l 148.86399841 16.68799973 l 139.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 148.86399841 1.25 m 154.68899536 1.25 l 154.68899536 16.68799973 l 148.86399841 16.68799973 l h f* Q q /GS2 gs 1 g 154.68899536 1.25 m 159.66400146 1.25 l 159.66400146 16.68799973 l 154.68899536 16.68799973 l h f* Q q /GS2 gs 1 g 159.66400146 1.25 m 165.48899841 1.25 l 165.48899841 16.68799973 l 159.66400146 16.68799973 l h f* Q q /GS2 gs 1 g 165.48899841 1.25 m 193.45100403 1.25 l 193.45100403 16.68799973 l 165.48899841 16.68799973 l h f* Q q /GS2 gs 1 g 193.45100403 1.25 m 199.27600098 1.25 l 199.27600098 16.68799973 l 193.45100403 16.68799973 l h f* Q q /GS2 gs 1 g 199.27600098 1.25 m 231.55799866 1.25 l 231.55799866 16.68799973 l 199.27600098 16.68799973 l h f* Q q /GS2 gs 1 g 231.55799866 1.25 m 237.38299561 1.25 l 237.38299561 16.68799973 l 231.55799866 16.68799973 l h f* Q q /GS2 gs 1 g 237.38299561 1.25 m 258.09399414 1.25 l 258.09399414 16.68799973 l 237.38299561 16.68799973 l h f* Q q /GS2 gs 1 g 258.09399414 1.25 m 263.91900635 1.25 l 263.91900635 16.68799973 l 258.09399414 16.68799973 l h f* Q q /GS2 gs 1 g 263.91900635 1.25 m 299.48001099 1.25 l 299.48001099 16.68799973 l 263.91900635 16.68799973 l h f* Q q /GS2 gs 1 g 299.48001099 1.25 m 305.30502319 1.25 l 305.30502319 16.68799973 l 299.48001099 16.68799973 l h f* Q q /GS2 gs 1 g 305.30499268 1.25 m 332.375 1.25 l 332.375 16.68799973 l 305.30499268 16.68799973 l h f* Q q /GS2 gs 1 g 332.375 1.25 m 338.20001221 1.25 l 338.20001221 16.68799973 l 332.375 16.68799973 l h f* Q q /GS2 gs 1 g 338.20001221 1.25 m 360.00601196 1.25 l 360.00601196 16.68799973 l 338.20001221 16.68799973 l h f* Q q /GS2 gs 1 g 360.00601196 1.25 m 365.83102417 1.25 l 365.83102417 16.68799973 l 360.00601196 16.68799973 l h f* Q q /GS2 gs 1 g 365.83099365 1.25 m 374.67300415 1.25 l 374.67300415 16.68799973 l 365.83099365 16.68799973 l h f* Q q /GS2 gs 1 g 374.67300415 1.25 m 380.49801636 1.25 l 380.49801636 16.68799973 l 374.67300415 16.68799973 l h f* Q q /GS2 gs 1 g 380.49798584 1.25 m 410.53900146 1.25 l 410.53900146 16.68799973 l 380.49798584 16.68799973 l h f* Q q /GS2 gs 1 g 410.53900146 1.25 m 413.20199585 1.25 l 413.20199585 16.68799973 l 410.53900146 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.98099899 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.28800201 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.11299896 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.96400452 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.78900146 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.86399841 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.68899536 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.66400146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.48899841 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.45100403 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.27600098 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.55799866 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.38299561 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09399414 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.91900635 12.89099979 Tm [(19)-1(2-39)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.48001099 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.30499268 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.375 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.20001221 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.00601196 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 365.83099365 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.67300415 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.49798584 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 410.53900146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC q 1 g 0 19.18899918 m 40.45199966 19.18899918 l 40.45199966 34.6269989 l 0 34.6269989 l h f* Q EMC /P <> BDC BT 1 0 0 -1 0 30.82999802 Tm [(RMND5A)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 40.45199966 30.82999802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 46.37799835 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 46.37799835 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 46.62799835 m 421.6000061 46.62799835 l S Q Q q 1 0 0 1 0 335.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 363.1289978 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 391.06799316 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 419.00698853 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.54100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04100037 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.81900024 11.72200012 Tm [(mei)-1(o)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.73600006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.23600006 11.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.7539978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.2539978 11.72200012 Tm [(division)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.35400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.85400391 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.13200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.63200378 11.72200012 Tm [(ho)1(molog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.92399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.42399597 11.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.75700378 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CTLH)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.9260006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.4260006 11.72200012 Tm [(GID)1(2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.06399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.56399918 11.72200012 Tm [(RMD5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.53299713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.03299713 11.72200012 Tm [(GID)1(2)-1(A)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.0039978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.5039978 11.72200012 Tm [(p44)-1(C)1(T)-1(LH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.56700134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(87)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.4070015 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(16)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 107.625 0.75 l 107.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.625 -0.25 l 108.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 108.375 16.35000038 l h f* Q q 1 0 0 1 108 0 cm -0.625 -0.25 m 315.42498779 -0.25 l 315.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.04800034 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.54800034 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.38999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.88999939 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.34600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.84600067 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.15299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.65299988 11.72200012 Tm [(remains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.71099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.21099854 11.72200012 Tm [(unk)-1(now)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.28900146 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 130.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 0.75 m 108 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 17.10000038 m 108 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 33.45000076 m 108 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 49.80000305 m 108 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 66.15000153 m 108 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 82.5 m 108 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 98.84999847 m 108 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108 115.19999695 m 108 130.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 130.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 131.17500305 m 423.17498779 131.17500305 l S Q Q q 1 0 0 1 0 550.55700684 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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