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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.39199829 23.67700005 Tm 0 g [(RIOK1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 150.20300293 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 326.90701294 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(RIOK1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 81.2009964 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.20100403 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RIOK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.0759964 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.44999695 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.65200043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.02600098 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.0059967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.38000488 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.85400391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RIO1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.43000031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.80400085 12.82499981 Tm [(AD034)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.11399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.48799896 12.82499981 Tm [(RRP1)1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.76800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.14199829 12.82499981 Tm [(bA288G)1(3.)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.61799622 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 274.18399048 1.25 l 274.18399048 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 274.18399048 1.25 m 276.84698486 1.25 l 276.84698486 16.68799973 l 274.18399048 16.68799973 l h f* Q q /GS2 gs 1 g 276.84698486 1.25 m 303.91699219 1.25 l 303.91699219 16.68799973 l 276.84698486 16.68799973 l h f* Q q /GS2 gs 1 g 303.91699219 1.25 m 306.57998657 1.25 l 306.57998657 16.68799973 l 303.91699219 16.68799973 l h f* Q q /GS2 gs 1 g 306.57998657 1.25 m 328.38598633 1.25 l 328.38598633 16.68799973 l 306.57998657 16.68799973 l h f* Q q /GS2 gs 1 g 328.38598633 1.25 m 331.04898071 1.25 l 331.04898071 16.68799973 l 328.38598633 16.68799973 l h f* Q q /GS2 gs 1 g 331.04901123 1.25 m 339.89102173 1.25 l 339.89102173 16.68799973 l 331.04901123 16.68799973 l h f* Q q /GS2 gs 1 g 339.89099121 1.25 m 342.5539856 1.25 l 342.5539856 16.68799973 l 339.89099121 16.68799973 l h f* Q q /GS2 gs 1 g 342.5539856 1.25 m 372.5949707 1.25 l 372.5949707 16.68799973 l 342.5539856 16.68799973 l h f* Q q /GS2 gs 1 g 372.59500122 1.25 m 375.25799561 1.25 l 375.25799561 16.68799973 l 372.59500122 16.68799973 l h f* Q q /GS2 gs 1 g 375.25799561 1.25 m 402.10400391 1.25 l 402.10400391 16.68799973 l 375.25799561 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(36)-1(9-56)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.18399048 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.84698486 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.91699219 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.57998657 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.38598633 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.04901123 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 339.89099121 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 342.5539856 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 372.59500122 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.25799561 12.89099979 Tm [(RIOK)1(1)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 402.10400391 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.57499695 16.35000038 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RIO)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.85499954 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.35499954 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.44300079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.94300079 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.22100067 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.57499695 16.35000038 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RIO1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.29999924 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.79999924 11.72200012 Tm [(AD)1(0)-1(34)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.98799896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.48799896 11.72200012 Tm [(RRP)1(1)-1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.46700287 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.96700287 11.72200012 Tm [(bA)1(2)-1(88)-1(G)1(3)-1(.)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.29600525 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.57499695 16.35000038 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(RS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.60699844 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.57499695 16.35000038 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(06)-1(10)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.57499695 16.35000038 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.57499695 16.35000038 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.57499695 16.35000038 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 102.82499695 0.75 l 102.82499695 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 103.82499695 -0.25 l 103.82499695 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.57499695 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 103.57499695 63.15000153 l h f* Q q 1 0 0 1 103.19999695 0 cm -0.625 -0.25 m 323.9750061 -0.25 l 323.9750061 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(competes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.25300598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.75300598 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.14900208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.64900208 11.72200012 Tm [(pICln)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.0039978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.5039978 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.78201294 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.28201294 11.72200012 Tm [(inc)-1(lusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.50601196 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.44199944 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.94199944 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.24900055 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.74900055 27.3220005 Tm [(arg)1(in)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.90499878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.40499878 27.3220005 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.38400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.88400269 27.3220005 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.16200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.66200256 27.3220005 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.30799866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.80799866 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.07000732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.57000732 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.04901123 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.54901123 27.3220005 Tm [(ta)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(gets)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.38199997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.88199997 42.92200089 Tm [(subst)1(rat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.89800262 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.39800262 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.6760025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.1760025 42.92200089 Tm [(dimeth)1(y)-1(lat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.07699585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.57699585 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.38400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.88400269 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.39100647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.89100647 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.19799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.69799805 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.25900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.75900269 42.92200089 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.9670105 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.4670105 42.92200089 Tm [(fo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.93799973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.43799973 58.52199936 Tm [(last)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.32699966 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.82699966 58.52199936 Tm [(st)1(e)-1(ps)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.36699677 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.86699677 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.80799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.30799866 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.30899811 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.80899811 58.52199936 Tm [(mat)1(u)-1(r)1(atio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.54200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.04200745 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.88400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.38400269 58.52199936 Tm [(40)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.13400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.63400269 58.52199936 Tm [(subunits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.26600647 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 0.75 m 103.19999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 17.10000038 m 103.19999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 33.45000076 m 103.19999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 49.80000305 m 103.19999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 66.15000153 m 103.19999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 82.5 m 103.19999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 98.84999847 m 103.19999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.19999695 115.19999695 m 103.19999695 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 426.92498779 177.9750061 l S Q Q q 1 0 0 1 0 561.47900391 cm Q Q 1 0 0 -1 0 841.90002441 cm
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