%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.23899841 23.67700005 Tm 0 g [(REG1B)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.35699463 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.06100464 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(REG1B)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.61000061 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.61000061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(REG1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.48500061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.85900116 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.06099701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.43499756 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.41499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.78900146 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.26300049 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(REGH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.80400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.1780014 12.82499981 Tm [(REGL)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.85399628 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.22799683 12.82499981 Tm [(PSPS2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.85699463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.23100281 12.82499981 Tm [(REGI-BET)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.57400513 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 268.90600586 1.25 l 268.90600586 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 268.90600586 1.25 m 271.56900024 1.25 l 271.56900024 16.68799973 l 268.90600586 16.68799973 l h f* Q q /GS2 gs 1 g 271.56900024 1.25 m 298.63900757 1.25 l 298.63900757 16.68799973 l 271.56900024 16.68799973 l h f* Q q /GS2 gs 1 g 298.63900757 1.25 m 301.30200195 1.25 l 301.30200195 16.68799973 l 298.63900757 16.68799973 l h f* Q q /GS2 gs 1 g 301.30200195 1.25 m 323.10800171 1.25 l 323.10800171 16.68799973 l 301.30200195 16.68799973 l h f* Q q /GS2 gs 1 g 323.10800171 1.25 m 325.77099609 1.25 l 325.77099609 16.68799973 l 323.10800171 16.68799973 l h f* Q q /GS2 gs 1 g 325.77099609 1.25 m 334.61300659 1.25 l 334.61300659 16.68799973 l 325.77099609 16.68799973 l h f* Q q /GS2 gs 1 g 334.61300659 1.25 m 337.27600098 1.25 l 337.27600098 16.68799973 l 334.61300659 16.68799973 l h f* Q q /GS2 gs 1 g 337.27600098 1.25 m 367.3170166 1.25 l 367.3170166 16.68799973 l 337.27600098 16.68799973 l h f* Q q /GS2 gs 1 g 367.31698608 1.25 m 369.97998047 1.25 l 369.97998047 16.68799973 l 367.31698608 16.68799973 l h f* Q q /GS2 gs 1 g 369.98001099 1.25 m 398.42102051 1.25 l 398.42102051 16.68799973 l 369.98001099 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(23)-1(-)1(1)-1(27)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.90600586 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.56900024 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.63900757 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.30200195 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.10800171 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.77099609 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.61300659 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.27600098 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 367.31698608 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 369.98001099 12.89099979 Tm [(REG)1(1)-1(B)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 398.42098999 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(regene)-1(ra)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.52099991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.02099991 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.10299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.60299683 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.86699677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.36700439 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.64500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.14500427 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.32699585 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(REG)1(H)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.6439991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.1439991 11.72200012 Tm [(REG)1(L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.44599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.94599915 11.72200012 Tm [(PSPS2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.79199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.29199982 11.72200012 Tm [(REG)1(I-BETA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.43499756 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P48)-1(30)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(27)-1(89)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 102.42500305 109.94999695 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.28500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.78500366 11.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.43099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.93099976 11.72200012 Tm [(subclass)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.10600281 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.36999512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.86999512 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.71200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.21200562 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.21299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.71299744 11.72200012 Tm [(Reg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45199585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.95199585 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.46800232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.96798706 11.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.21600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.71600342 11.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.52301025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(Reg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.73900032 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.23900032 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.75500107 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25500107 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.33699799 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.83699799 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.39800262 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.89800262 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.8730011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.3730011 27.3220005 Tm [(multigene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.01100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.51100159 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.59300232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.09300232 27.3220005 Tm [(gr)1(ouped)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.16499329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.66499329 27.3220005 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.18099976 27.3220005 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.00500488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.50500488 27.3220005 Tm [(subclasses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.61898804 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(types)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.13699913 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.63699913 42.92200089 Tm [(I,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.44900131 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.94900131 42.92200089 Tm [(II,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.4070015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.9070015 42.92200089 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.84400177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.34400177 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.6210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.1210022 42.92200089 Tm [(IV)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.85299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.35299683 42.92200089 Tm [(ba)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.10500336 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.60500336 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.8730011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.3730011 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.37399292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.87399292 42.92200089 Tm [(prima)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.06199646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.56199646 42.92200089 Tm [(st)1(ruc)-1(tures)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.18499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.68499756 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.5269928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.02700806 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.02801514 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52801514 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.03500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.63899994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.13899994 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.40100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.90100098 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.41699982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.91699982 58.52199936 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.83399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.33399963 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.30900574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.80900574 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.11599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.61599731 58.52199936 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.16099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.66099548 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.17300415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.67300415 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.67399597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.17399597 58.52199936 Tm [(exocrin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.56100464 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.06100464 58.52199936 Tm [(pa)1(n)-1(cr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(eas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.24699974 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.74699974 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.96900177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.46900177 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.02999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.52999878 74.12200165 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.9240036 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.4240036 74.12200165 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.6190033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.1190033 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.69400024 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.69500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.19500732 74.12200165 Tm [(REG)1(1)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.32200623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.82200623 74.12200165 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.29499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.79499817 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.602005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.102005 74.12200165 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.23098755 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.73098755 74.12200165 Tm [(REG)1(1)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.85800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.35800171 74.12200165 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.18299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.68299866 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.80999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.30999756 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.70600128 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.20600128 89.72200012 Tm [(isle)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.62200165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.12199402 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.53199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.03199768 89.72200012 Tm [(regene)-1(ra)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.51699829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.01699829 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.29400635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.79400635 89.72200012 Tm [(dia)1(be)-1(t)1(og)1(e)-1(nesis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.25900269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.75900269 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.4279995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9280014 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.7820015 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.2820015 105.3219986 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.65100098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.15100098 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.09200287 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.59200287 105.3219986 Tm [(pa)1(n)-1(creatic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.15299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.65299988 105.3219986 Tm [(litho)1(gene)-1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.46800232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.96800232 105.3219986 Tm [(Reg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.70700073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.20700073 105.3219986 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.28900146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.78900146 105.3219986 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.21899414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.71899414 105.3219986 Tm [(RE)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 0.75 m 102.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 17.10000038 m 102.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 33.45000076 m 102.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 49.80000305 m 102.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 66.15000153 m 102.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 82.5 m 102.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 98.84999847 m 102.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 115.19999695 m 102.05000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>