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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.4240036 23.67700005 Tm 0 g [(RBM1)1(9)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 155.17100525 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 331.875 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(RBM19)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 86.15799713 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.15800476 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RBM19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.03299713 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.40699768 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.60899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.98300171 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.96299744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.33700562 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81100464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mrd1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.47599792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 274.18399048 1.25 l 274.18399048 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 274.18399048 1.25 m 276.84698486 1.25 l 276.84698486 16.68799973 l 274.18399048 16.68799973 l h f* Q q /GS2 gs 1 g 276.84698486 1.25 m 303.91699219 1.25 l 303.91699219 16.68799973 l 276.84698486 16.68799973 l h f* Q q /GS2 gs 1 g 303.91699219 1.25 m 306.57998657 1.25 l 306.57998657 16.68799973 l 303.91699219 16.68799973 l h f* Q q /GS2 gs 1 g 306.57998657 1.25 m 328.38598633 1.25 l 328.38598633 16.68799973 l 306.57998657 16.68799973 l h f* Q q /GS2 gs 1 g 328.38598633 1.25 m 331.04898071 1.25 l 331.04898071 16.68799973 l 328.38598633 16.68799973 l h f* Q q /GS2 gs 1 g 331.04901123 1.25 m 339.89102173 1.25 l 339.89102173 16.68799973 l 331.04901123 16.68799973 l h f* Q q /GS2 gs 1 g 339.89099121 1.25 m 342.5539856 1.25 l 342.5539856 16.68799973 l 339.89099121 16.68799973 l h f* Q q /GS2 gs 1 g 342.5539856 1.25 m 372.5949707 1.25 l 372.5949707 16.68799973 l 342.5539856 16.68799973 l h f* Q q /GS2 gs 1 g 372.59500122 1.25 m 375.25799561 1.25 l 375.25799561 16.68799973 l 372.59500122 16.68799973 l h f* Q q /GS2 gs 1 g 375.25799561 1.25 m 406.13000488 1.25 l 406.13000488 16.68799973 l 375.25799561 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(76)-1(1-96)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.18399048 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.84698486 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.91699219 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.57998657 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.38598633 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.04901123 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 339.89099121 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 342.5539856 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 372.59500122 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.25799561 12.89099979 Tm [(RBM1)-1(9)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 406.13000488 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.02500153 16.35000038 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52499962 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.02499962 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.16899872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66899872 11.72200012 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.69200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.19200134 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.49900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.99900055 11.72200012 Tm [(19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.55499268 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.02500153 16.35000038 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Mrd1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.26499939 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.02500153 16.35000038 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y4C8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.61999893 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.02500153 16.35000038 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(04)-1(28)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.02500153 16.35000038 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.02500153 16.35000038 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.02500153 16.35000038 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 123.27500153 0.75 l 123.27500153 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 124.27500153 -0.25 l 124.27500153 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.02500153 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 124.02500153 63.15000153 l h f* Q q 1 0 0 1 123.65000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(nuc)-1(leolar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.30400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.80400085 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.11099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.61099243 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.83299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.33299255 11.72200012 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.54800415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.04800415 11.72200012 Tm [(six)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.17100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.67100525 11.72200012 Tm [(RNA)1(-bin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.45499992 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.95499992 27.3220005 Tm [(mot)1(ifs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.31000137 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.81000137 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.61699677 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.11699677 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.62400055 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.12400055 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.43099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93099976 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.102005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.602005 27.3220005 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.45599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.95599365 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.32499695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.82499695 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.76600647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.26600647 27.3220005 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.53201294 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ribo)1(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.72900009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.22900009 42.92200089 Tm [(biog)1(e)-1(nesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.50299835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.00299835 42.92200089 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.73500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.23500061 42.92200089 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.75799561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.25799561 42.92200089 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.33900452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.83900452 42.92200089 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.57501221 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.07501221 42.92200089 Tm [(en)-1(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.45499992 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.95499992 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.95600128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.45600128 58.52199936 Tm [(same)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.13600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.63600159 58.52199936 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.10900116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.60900116 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.95600128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.45599365 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.96299744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.46299744 58.52199936 Tm [(identified.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.55999756 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 0.75 m 123.65000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 17.10000038 m 123.65000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 33.45000076 m 123.65000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 49.80000305 m 123.65000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 66.15000153 m 123.65000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 82.5 m 123.65000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 98.84999847 m 123.65000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.65000153 115.19999695 m 123.65000153 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 426.92498779 177.9750061 l S Q Q q 1 0 0 1 0 561.47900391 cm Q Q 1 0 0 -1 0 841.90002441 cm
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