%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.78900146 23.67700005 Tm 0 g [(RAB)1(3IL1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 159.80700684 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 336.51098633 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(RAB3)1(IL)-1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.31600189 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.31599426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RAB3)1(IL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.19100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.56500244 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.76699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.14100647 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.1210022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.49499512 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.96899414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(GRA)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.11199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 47.37799835 l -0.75 47.37799835 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 33.98099899 1.25 l 33.98099899 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 33.98099899 1.25 m 65.28799438 1.25 l 65.28799438 16.68799973 l 33.98099899 16.68799973 l h f* Q q /GS2 gs 1 g 65.28800201 1.25 m 71.11299896 1.25 l 71.11299896 16.68799973 l 65.28800201 16.68799973 l h f* Q q /GS2 gs 1 g 71.11299896 1.25 m 133.96400452 1.25 l 133.96400452 16.68799973 l 71.11299896 16.68799973 l h f* Q q /GS2 gs 1 g 133.96400452 1.25 m 139.78900146 1.25 l 139.78900146 16.68799973 l 133.96400452 16.68799973 l h f* Q q /GS2 gs 1 g 139.78900146 1.25 m 148.86399841 1.25 l 148.86399841 16.68799973 l 139.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 148.86399841 1.25 m 154.68899536 1.25 l 154.68899536 16.68799973 l 148.86399841 16.68799973 l h f* Q q /GS2 gs 1 g 154.68899536 1.25 m 159.66400146 1.25 l 159.66400146 16.68799973 l 154.68899536 16.68799973 l h f* Q q /GS2 gs 1 g 159.66400146 1.25 m 165.48899841 1.25 l 165.48899841 16.68799973 l 159.66400146 16.68799973 l h f* Q q /GS2 gs 1 g 165.48899841 1.25 m 193.45100403 1.25 l 193.45100403 16.68799973 l 165.48899841 16.68799973 l h f* Q q /GS2 gs 1 g 193.45100403 1.25 m 199.27600098 1.25 l 199.27600098 16.68799973 l 193.45100403 16.68799973 l h f* Q q /GS2 gs 1 g 199.27600098 1.25 m 231.55799866 1.25 l 231.55799866 16.68799973 l 199.27600098 16.68799973 l h f* Q q /GS2 gs 1 g 231.55799866 1.25 m 237.38299561 1.25 l 237.38299561 16.68799973 l 231.55799866 16.68799973 l h f* Q q /GS2 gs 1 g 237.38299561 1.25 m 258.09399414 1.25 l 258.09399414 16.68799973 l 237.38299561 16.68799973 l h f* Q q /GS2 gs 1 g 258.09399414 1.25 m 263.91900635 1.25 l 263.91900635 16.68799973 l 258.09399414 16.68799973 l h f* Q q /GS2 gs 1 g 263.91900635 1.25 m 299.48001099 1.25 l 299.48001099 16.68799973 l 263.91900635 16.68799973 l h f* Q q /GS2 gs 1 g 299.48001099 1.25 m 305.30502319 1.25 l 305.30502319 16.68799973 l 299.48001099 16.68799973 l h f* Q q /GS2 gs 1 g 305.30499268 1.25 m 332.375 1.25 l 332.375 16.68799973 l 305.30499268 16.68799973 l h f* Q q /GS2 gs 1 g 332.375 1.25 m 338.20001221 1.25 l 338.20001221 16.68799973 l 332.375 16.68799973 l h f* Q q /GS2 gs 1 g 338.20001221 1.25 m 360.00601196 1.25 l 360.00601196 16.68799973 l 338.20001221 16.68799973 l h f* Q q /GS2 gs 1 g 360.00601196 1.25 m 365.83102417 1.25 l 365.83102417 16.68799973 l 360.00601196 16.68799973 l h f* Q q /GS2 gs 1 g 365.83099365 1.25 m 374.67300415 1.25 l 374.67300415 16.68799973 l 365.83099365 16.68799973 l h f* Q q /GS2 gs 1 g 374.67300415 1.25 m 380.49801636 1.25 l 380.49801636 16.68799973 l 374.67300415 16.68799973 l h f* Q q /GS2 gs 1 g 380.49798584 1.25 m 410.53900146 1.25 l 410.53900146 16.68799973 l 380.49798584 16.68799973 l h f* Q q /GS2 gs 1 g 410.53900146 1.25 m 413.20199585 1.25 l 413.20199585 16.68799973 l 410.53900146 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.98099899 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.28800201 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.11299896 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.96400452 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.78900146 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.86399841 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.68899536 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.66400146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.48899841 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.45100403 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.27600098 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.55799866 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.38299561 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09399414 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.91900635 12.89099979 Tm [(18)-1(3-38)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.48001099 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.30499268 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.375 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.20001221 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.00601196 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 365.83099365 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.67300415 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.49798584 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 410.53900146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC q 1 g 0 19.18899918 m 35.67499924 19.18899918 l 35.67499924 34.6269989 l 0 34.6269989 l h f* Q EMC /P <> BDC BT 1 0 0 -1 0 30.82999802 Tm [(RA)1(B)-1(3IL1)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 35.67499924 30.82999802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 46.37799835 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 46.37799835 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 46.62799835 m 421.6000061 46.62799835 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 134.9750061 16.35000038 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RA)1(B)-1(3A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.46500015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.96500015 11.72200012 Tm [(interacting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.33999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.83999634 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.14700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.64700317 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.44299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.94299316 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.22099304 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 134.9750061 16.35000038 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(GR)1(AB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.54800034 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 134.9750061 16.35000038 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8T)-1(BN0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.01300049 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 134.9750061 16.35000038 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(22)-1(23)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 134.9750061 16.35000038 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 134.9750061 16.35000038 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 134.9750061 16.35000038 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 134.2250061 0.75 l 134.2250061 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 135.2250061 -0.25 l 135.2250061 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 134.9750061 0.75 m 426.17501831 0.75 l 426.17501831 78.75 l 134.9750061 78.75 l h f* Q q 1 0 0 1 134.6000061 0 cm -0.625 -0.25 m 292.57501221 -0.25 l 292.57501221 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(guanine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.54100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.04100037 11.72200012 Tm [(nuc)-1(leotid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.47999573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.97999573 11.72200012 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.08599854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.58599854 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.70498657 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.20498657 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.48300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.98300171 11.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 27.3220005 Tm [(ras)1(-related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.7480011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.2480011 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.55500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.05500031 27.3220005 Tm [(Rab)1(3)-1(A)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.42999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.92999268 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.73699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.23699951 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.7440033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.2440033 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.55099487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.05099487 27.3220005 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.66299438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.16299438 27.3220005 Tm [(Rab)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(3a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25199986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.75199986 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.02899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.52899933 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.52999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.02999878 42.92200089 Tm [(inosito)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.72299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.22299957 42.92200089 Tm [(hexakispho)1(spha)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.76899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.26899719 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.35699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.85699463 42.92200089 Tm [(InsP6K1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.15600586 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.65600586 42.92200089 Tm [(Alt)1(e)-1(rna)1(ti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.83100033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.33100033 58.52199936 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.24599838 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.74599838 58.52199936 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.91500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.41500092 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.35600281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.85600281 58.52199936 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.22799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.72799683 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.6499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.1499939 58.52199936 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.88600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.38600159 58.52199936 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.71899414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.21899414 58.52199936 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.34799194 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.84799194 58.52199936 Tm [(pse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(udog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.54000092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.04000092 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.72200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.22200012 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.72899628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.22899628 74.12200165 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.16000366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.66000366 74.12200165 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.92799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.42799377 74.12200165 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.2230072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.7230072 74.12200165 Tm [(7.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.16700745 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 0.75 m 134.6000061 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 17.10000038 m 134.6000061 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 33.45000076 m 134.6000061 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 49.80000305 m 134.6000061 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 66.15000153 m 134.6000061 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 82.5 m 134.6000061 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 98.84999847 m 134.6000061 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 134.6000061 115.19999695 m 134.6000061 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92501831 193.57499695 l S Q Q q 1 0 0 1 0 595.01800537 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>