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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.63999939 23.67700005 Tm 0 g [(PPM1G)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 155.95500183 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 332.65899658 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(PP)1(M1G)] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 84.27200317 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.52200317 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.52200317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PP)1(M1G)] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 94.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 97.14600372 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 130.3480072 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 132.72200012 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 192.70199585 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 195.07600403 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 229.55000305 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 18 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 19 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(protein)] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 94.38200378 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 96.7559967 12.82499981 Tm [(ph)-1(osp)-1(hatase,)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 153.99299622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 156.36700439 12.82499981 Tm [(Mg2+/Mn2+)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 209.93899536 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 212.31300354 12.82499981 Tm [(depend)-1(e)1(n)-1(t)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 259.08599854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 261.45999146 12.82499981 Tm [(1G;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 276.21499634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 278.58898926 12.82499981 Tm [(PP)1(2CG;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 309.79199219 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 312.16598511 12.82499981 Tm [(PP)1(P2CG;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 348.79299927 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 351.16699219 12.82499981 Tm [(PP)1(2CGAMMA)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 409.66598511 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 54 >> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 274.18399048 1.25 l 274.18399048 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 274.18399048 1.25 m 276.84698486 1.25 l 276.84698486 16.68799973 l 274.18399048 16.68799973 l h f* Q q /GS2 gs 1 g 276.84698486 1.25 m 303.91699219 1.25 l 303.91699219 16.68799973 l 276.84698486 16.68799973 l h f* Q q /GS2 gs 1 g 303.91699219 1.25 m 306.57998657 1.25 l 306.57998657 16.68799973 l 303.91699219 16.68799973 l h f* Q q /GS2 gs 1 g 306.57998657 1.25 m 328.38598633 1.25 l 328.38598633 16.68799973 l 306.57998657 16.68799973 l h f* Q q /GS2 gs 1 g 328.38598633 1.25 m 331.04898071 1.25 l 331.04898071 16.68799973 l 328.38598633 16.68799973 l h f* Q q /GS2 gs 1 g 331.04901123 1.25 m 339.89102173 1.25 l 339.89102173 16.68799973 l 331.04901123 16.68799973 l h f* Q q /GS2 gs 1 g 339.89099121 1.25 m 342.5539856 1.25 l 342.5539856 16.68799973 l 339.89099121 16.68799973 l h f* Q q /GS2 gs 1 g 342.5539856 1.25 m 372.5949707 1.25 l 372.5949707 16.68799973 l 342.5539856 16.68799973 l h f* Q q /GS2 gs 1 g 372.59500122 1.25 m 375.25799561 1.25 l 375.25799561 16.68799973 l 372.59500122 16.68799973 l h f* Q q /GS2 gs 1 g 375.25799561 1.25 m 407.03500366 1.25 l 407.03500366 16.68799973 l 375.25799561 16.68799973 l h f* Q EMC /P <</MCID 55 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(34)-1(7-54)-1(6)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 274.18399048 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 276.84698486 12.89099979 Tm [(amino)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 303.91699219 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 306.57998657 12.89099979 Tm [(acids)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 328.38598633 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 331.04901123 12.89099979 Tm [(of)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 339.89099121 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 342.5539856 12.89099979 Tm [(human)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 372.59500122 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 375.25799561 12.89099979 Tm [(PPM1G)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 407.03500366 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <</MCID 83 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(pro)1(tein)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 31.30699921 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 35.80699921 11.72200012 Tm [(ph)1(osph)1(ata)1(se)-1(,)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 93.01499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 97.51499939 11.72200012 Tm [(Mg2+/Mn2)-1(+)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 154.15600586 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 158.65600586 11.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 205.68200684 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 210.18200684 11.72200012 Tm [(1G)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 222.15299988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 102 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PP2CG;)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 31.17000008 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 35.66999817 11.72200012 Tm [(PPP)1(2)-1(CG)1(;)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 72.34700012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 76.84700012 11.72200012 Tm [(PP2CGA)1(MMA)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 136.10299683 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 109 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 110 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O15)-1(35)-1(5)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 116 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 117 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(00)-1(05)-1(7)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 120 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 137 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 140 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 141 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 145 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 146 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 105.67500305 16.35000038 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 147 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 104.92500305 0.75 l 104.92500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 105.92500305 -0.25 l 105.92500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 159 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 160 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 105.67500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 105.67500305 109.94999695 l h f* Q q 1 0 0 1 105.30000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 161 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(PP2C)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 274.55899048 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 279.05899048 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 305.14099121 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(Se)-1(r)1(/)-1(Thr)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 45.06200027 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 49.56200027 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 80.8690033 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 85.3690033 27.3220005 Tm [(ph)1(osph)1(ata)1(se)-1(s.)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 146.74299622 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 151.24299622 27.3220005 Tm [(PP2C)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 173.55400085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 178.05400085 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 204.13600159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 208.63600159 27.3220005 Tm [(members)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 249.06599426 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 253.56599426 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 267.08401489 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 271.58401489 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 300.40301514 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 304.90301514 27.3220005 Tm [(t)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(o)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 5.72200012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 10.22200012 42.92200089 Tm [(be)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 21.07600021 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 25.57600021 42.92200089 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 62.5379982 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 67.03800201 42.92200089 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 110.93099976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 115.43099976 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 124.27300262 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 128.772995 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 143.18299866 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 147.68299866 42.92200089 Tm [(st)1(re)-1(ss)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 172.07699585 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 176.57699585 42.92200089 Tm [(response)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 215.57400513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 220.07400513 42.92200089 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 262.86801147 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 267.36801147 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 284.63000488 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 289.13000488 42.92200089 Tm [(ph)1(o)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(sph)1(ata)1(se)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 38.02999878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 42.52999878 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 49.0909996 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 53.5909996 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 79.28099823 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 83.78099823 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 92.85600281 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 97.35600281 58.52199936 Tm [(be)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 108.20999908 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 112.70999908 58.52199936 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 162.24499512 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 166.74499512 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 179.022995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 183.522995 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 197.52400208 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 202.02400208 58.52199936 Tm [(deph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 283.66101074 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 288.16101074 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 297.00299072 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 301.50299072 58.52199936 Tm [(P)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(re-mRNA)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 40.39500046 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 44.89500046 74.12200165 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 77.80999756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 82.30999756 74.12200165 Tm [(fa)1(c)-1(t)1(ors,)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 113.76200104 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 118.26200104 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 143.35899353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 147.85899353 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 154.41999817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 158.91999817 74.12200165 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 201.8809967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 206.3809967 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 218.65899658 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 223.15899658 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 237.16000366 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 241.66000366 74.12200165 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 284.36199951 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 288.86199951 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 297.70401001 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 302.20401001 74.12200165 Tm [(f)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(unc)-1(t)1(i)-1(o)1(n)-1(a)1(l)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 39.99000168 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 44.49000168 89.72200012 Tm [(splice)-1(o)1(some.)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 100.1289978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 104.6289978 89.72200012 Tm [(Studies)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 136.14700317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 140.64700317 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 149.48899841 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 153.98899841 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 158.96400452 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 163.46400452 89.72200012 Tm [(similar)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 191.65899658 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 196.15899658 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 217.67500305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 222.17500305 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 230.11599731 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 234.61599731 89.72200012 Tm [(mic)-1(e)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 255.06399536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 259.56399536 89.72200012 Tm [(sugg)1(e)-1(st)1(e)-1(d)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 304.27801514 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 4.9749999 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 9.47500038 105.3219986 Tm [(role)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 26.13500023 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 30.63500023 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 39.47700119 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 43.97700119 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 59.43299866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 63.93299866 105.3219986 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 118.97499847 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 123.47499847 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 131.41600037 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 135.91600037 105.3219986 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 180.18200684 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 184.68200684 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 199.09199524 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 203.59199524 105.3219986 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 224.88400269 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 229.38400269 105.3219986 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 282.75100708 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 0.75 m 105.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 17.10000038 m 105.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 33.45000076 m 105.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 49.80000305 m 105.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 66.15000153 m 105.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 82.5 m 105.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 98.84999847 m 105.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 105.30000305 115.19999695 m 105.30000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 423.17498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm 
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