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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.48300171 23.67700005 Tm 0 g [(PPM1B)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 155.11199951 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 331.81600952 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(PP)1(M1B)] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.98400116 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.98399353 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PP)1(M1B)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 93.85900116 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 96.23300171 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 129.43499756 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 131.80900574 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 191.78900146 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 194.16299438 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 228.63699341 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PP)1(2CB;)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 93.29000092 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 95.66400146 12.82499981 Tm [(PP)1(2CBET)-1(A)1(;)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 142.272995 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 144.64700317 12.82499981 Tm [(PP)1(2C-b)-1(e)1(ta;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 191.72799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 194.102005 12.82499981 Tm [(PP)1(C2BET)-1(A)1(X;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 246.16099548 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 248.53500366 12.82499981 Tm [(PP)1(2C-b)-1(e)1(ta-X)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 301.4710083 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 47 >> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 274.18399048 1.25 l 274.18399048 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 274.18399048 1.25 m 276.84698486 1.25 l 276.84698486 16.68799973 l 274.18399048 16.68799973 l h f* Q q /GS2 gs 1 g 276.84698486 1.25 m 303.91699219 1.25 l 303.91699219 16.68799973 l 276.84698486 16.68799973 l h f* Q q /GS2 gs 1 g 303.91699219 1.25 m 306.57998657 1.25 l 306.57998657 16.68799973 l 303.91699219 16.68799973 l h f* Q q /GS2 gs 1 g 306.57998657 1.25 m 328.38598633 1.25 l 328.38598633 16.68799973 l 306.57998657 16.68799973 l h f* Q q /GS2 gs 1 g 328.38598633 1.25 m 331.04898071 1.25 l 331.04898071 16.68799973 l 328.38598633 16.68799973 l h f* Q q /GS2 gs 1 g 331.04901123 1.25 m 339.89102173 1.25 l 339.89102173 16.68799973 l 331.04901123 16.68799973 l h f* Q q /GS2 gs 1 g 339.89099121 1.25 m 342.5539856 1.25 l 342.5539856 16.68799973 l 339.89099121 16.68799973 l h f* Q q /GS2 gs 1 g 342.5539856 1.25 m 372.5949707 1.25 l 372.5949707 16.68799973 l 342.5539856 16.68799973 l h f* Q q /GS2 gs 1 g 372.59500122 1.25 m 375.25799561 1.25 l 375.25799561 16.68799973 l 372.59500122 16.68799973 l h f* Q q /GS2 gs 1 g 375.25799561 1.25 m 405.98898315 1.25 l 405.98898315 16.68799973 l 375.25799561 16.68799973 l h f* Q EMC /P <</MCID 48 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(28)-1(8-47)-1(9)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 274.18399048 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 276.84698486 12.89099979 Tm [(amino)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 303.91699219 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 306.57998657 12.89099979 Tm [(acids)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 328.38598633 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 331.04901123 12.89099979 Tm [(of)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 339.89099121 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 342.5539856 12.89099979 Tm [(human)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 372.59500122 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 375.25799561 12.89099979 Tm [(PPM1B)] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 405.98901367 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <</MCID 79 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.2749939 16.35000038 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 84 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(pro)1(tein)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 31.30699921 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 35.80699921 11.72200012 Tm [(ph)1(osph)1(ata)1(se)-1(,)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 93.01499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 97.51499939 11.72200012 Tm [(Mg2+/Mn2)-1(+)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 154.15600586 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 158.65600586 11.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 205.68200684 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 210.18200684 11.72200012 Tm [(1B)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 221.10699463 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.2749939 16.35000038 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PP2CB;)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 30.125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 34.625 11.72200012 Tm [(PP2CBETA;)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 81.18900299 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 85.68900299 11.72200012 Tm [(PP2C-b)1(e)-1(t)1(a;)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 133.24200439 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 137.74200439 11.72200012 Tm [(PPC2BETAX;)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 190.11199951 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 194.61199951 11.72200012 Tm [(PP2C-b)1(e)-1(t)1(a-X)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 249.69700623 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 107 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.2749939 16.35000038 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O75)-1(68)-1(8)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 113 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.2749939 16.35000038 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 114 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(00)-1(2)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 116 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 117 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.2749939 16.35000038 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 118 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 134 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 137 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.2749939 16.35000038 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 138 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 142 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 143 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 143.2749939 16.35000038 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 144 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 142.5249939 0.75 l 142.5249939 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 143.5249939 -0.25 l 143.5249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 156 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 157 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 143.2749939 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 143.2749939 109.94999695 l h f* Q q 1 0 0 1 142.8999939 0 cm -0.625 -0.25 m 284.2749939 -0.25 l 284.2749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 158 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(PP2C)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 274.55899048 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 26.08200073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 30.58200073 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 39.42399979 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 43.92399979 27.3220005 Tm [(Se)-1(r)1(/)-1(Thr)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 75.64399719 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 80.14399719 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 111.4509964 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 115.9509964 27.3220005 Tm [(ph)1(osph)1(ata)1(se)-1(s.)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 177.32499695 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 181.82499695 27.3220005 Tm [(PP2C)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 204.13600159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 208.63600159 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 234.71800232 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 239.21800232 27.3220005 Tm [(member)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(are)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 22.18400002 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 26.68400002 42.92200089 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 55.50299835 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 60.00299835 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 69.07800293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 73.57800293 42.92200089 Tm [(be)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 84.43199921 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 88.93199921 42.92200089 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 125.89399719 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 130.39399719 42.92200089 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 174.28700256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 178.78700256 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 187.6289978 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 192.1289978 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 206.53900146 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 211.03900146 42.92200089 Tm [(st)1(re)-1(ss)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 235.43299866 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 239.93299866 42.92200089 Tm [(respons)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 52.40000153 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 56.90000153 58.52199936 Tm [(This)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 74.16200256 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 78.66200256 58.52199936 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 133.70399475 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 138.20399475 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 152.88600159 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 157.38600159 58.52199936 Tm [(been)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 178.89300537 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 183.39300537 58.52199936 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 211.47399902 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 215.97399902 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 225.04899597 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 229.54899597 58.52199936 Tm [(deph)1(osph)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(orylat)1(e)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 29.75099945 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 34.25099945 74.12200165 Tm [(cy)-1(clin)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 109.29599762 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 113.79599762 74.12200165 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 145.05000305 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 149.55000305 74.12200165 Tm [(\(CDK)1(s\),)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 180.48300171 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 184.98300171 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 201.25999451 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 205.75999451 74.12200165 Tm [(th)1(us)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 224.36599731 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 228.86599731 74.12200165 Tm [(may)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 247.03700256 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 251.53700256 74.12200165 Tm [(be)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 262.39099121 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 266.89099121 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(volved)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 28.4279995 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 32.9280014 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 40.86899948 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 45.36899948 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 59.77899933 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 64.27899933 89.72200012 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 85.57099915 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 90.07099915 89.72200012 Tm [(control.)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 122.92500305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 127.42500305 89.72200012 Tm [(Overexpression)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 193.97999573 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 198.47999573 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 207.32200623 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 211.82200623 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 227.27799988 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 231.77799988 89.72200012 Tm [(ph)1(osph)1(at)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ase)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 14.24699974 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 18.74699974 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 25.30800056 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 29.80800056 105.3219986 Tm [(repor)1(ted)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 67.47399902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 71.97399902 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 81.0490036 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 85.5490036 105.3219986 Tm [(cause)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 109.85500336 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 114.35500336 105.3219986 Tm [(ce)-1(ll-g)1(row)1(th)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 163.57400513 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 168.07400513 105.3219986 Tm [(arr)1(e)-1(st)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 192.54699707 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 197.04699707 105.3219986 Tm [(or)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 206.20500183 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 210.70500183 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 225.11500549 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 229.61500549 105.3219986 Tm [(deat)1(h.)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 256.51400757 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 261.01400757 105.3219986 Tm [(Alt)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 0.75 m 142.8999939 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 17.10000038 m 142.8999939 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 33.45000076 m 142.8999939 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 49.80000305 m 142.8999939 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 66.15000153 m 142.8999939 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 82.5 m 142.8999939 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 98.84999847 m 142.8999939 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.8999939 115.19999695 m 142.8999939 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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