%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.26000214 23.67700005 Tm 0 g [(PPC)-1(DC)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.33500671 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.03900146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(PP)1(CD)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.0059967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 86.2559967 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.2559967 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PP)1(CD)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.5059967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.87999725 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.08200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.45599365 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.43600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.80999756 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.28399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ph)-1(osp)-1(hop)-1(antoth)-1(e)1(n)-1(oylcyste)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.02999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.40400696 12.82499981 Tm [(decar)1(b)-1(oxylas)-1(e)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.20901489 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.58300781 12.82499981 Tm [(coaC;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.99798584 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.37200928 12.82499981 Tm [(MDS)-1(01)1(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.40899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.7829895 12.82499981 Tm [(PP)1(C-)-1(DC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.50299072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 263.62799072 1.25 l 263.62799072 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 263.62799072 1.25 m 266.29098511 1.25 l 266.29098511 16.68799973 l 263.62799072 16.68799973 l h f* Q q /GS2 gs 1 g 266.29098511 1.25 m 293.36099243 1.25 l 293.36099243 16.68799973 l 266.29098511 16.68799973 l h f* Q q /GS2 gs 1 g 293.36099243 1.25 m 296.02398682 1.25 l 296.02398682 16.68799973 l 293.36099243 16.68799973 l h f* Q q /GS2 gs 1 g 296.02398682 1.25 m 317.82998657 1.25 l 317.82998657 16.68799973 l 296.02398682 16.68799973 l h f* Q q /GS2 gs 1 g 317.82998657 1.25 m 320.49298096 1.25 l 320.49298096 16.68799973 l 317.82998657 16.68799973 l h f* Q q /GS2 gs 1 g 320.49301147 1.25 m 329.33502197 1.25 l 329.33502197 16.68799973 l 320.49301147 16.68799973 l h f* Q q /GS2 gs 1 g 329.33499146 1.25 m 331.99798584 1.25 l 331.99798584 16.68799973 l 329.33499146 16.68799973 l h f* Q q /GS2 gs 1 g 331.99798584 1.25 m 362.03900146 1.25 l 362.03900146 16.68799973 l 331.99798584 16.68799973 l h f* Q q /GS2 gs 1 g 362.03900146 1.25 m 364.70199585 1.25 l 364.70199585 16.68799973 l 362.03900146 16.68799973 l h f* Q q /GS2 gs 1 g 364.70199585 1.25 m 394.61099243 1.25 l 394.61099243 16.68799973 l 364.70199585 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(1-20)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.62799072 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.29098511 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.36099243 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.02398682 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.82998657 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.49301147 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.33499146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.99798584 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.03900146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 364.70199585 12.89099979 Tm [(PPCD)1(C)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 394.61099243 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.375 16.35000038 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ph)1(osph)1(opant)1(oth)1(e)-1(noylc)-1(yst)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.90899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.40899658 11.72200012 Tm [(decarbo)1(xy)-1(la)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.63400269 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.375 16.35000038 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(coaC;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.39599991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.89599991 11.72200012 Tm [(MDS01)-1(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.73899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23899841 11.72200012 Tm [(PPC-)1(DC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.04199982 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.375 16.35000038 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(CD)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.04399872 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.375 16.35000038 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(14)-1(40)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.375 16.35000038 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.375 16.35000038 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 103.375 16.35000038 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 102.625 0.75 l 102.625 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 103.625 -0.25 l 103.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 103.375 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 103.375 78.75 l h f* Q q 1 0 0 1 103 0 cm -0.625 -0.25 m 324.17498779 -0.25 l 324.17498779 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Bi)-1(o)1(syn)-1(t)1(hesis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.96699905 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.46699905 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.30899811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.80899811 11.72200012 Tm [(coe)-1(nz)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.42500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.92500305 11.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.25800323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.75799561 11.72200012 Tm [(\(CoA)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.84399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.34399414 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.05499268 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55499268 11.72200012 Tm [(pa)1(n)-1(t)1(ot)1(he)-1(nic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.35299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.85299683 11.72200012 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.49301147 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.99301147 11.72200012 Tm [(\(vita)1(min)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.82000732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.32000732 11.72200012 Tm [(B5)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.25100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.58200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08200073 27.3220005 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.29000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.79000092 27.3220005 Tm [(uni)-1(v)1(e)-1(rsa)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.08000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.58000183 27.3220005 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.04100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.54100037 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.48199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98199463 27.3220005 Tm [(pro)1(k)-1(a)1(ry)-1(o)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.30999756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.80999756 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.08700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.58700562 27.3220005 Tm [(eu)-1(karyot)1(e)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.82800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.32800293 27.3220005 Tm [(PPC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(DC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.8760004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.37599945 42.92200089 Tm [(\(EC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.35099983 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.85100174 42.92200089 Tm [(4.1)-1(.)1(1)-1(.)1(3)-1(6\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.91200256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.41200256 42.92200089 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.78600311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.28600311 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.12799835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.62799835 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.6289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.1289978 42.92200089 Tm [(last)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.01800537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.51800537 42.92200089 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.06500244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.56500244 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.5059967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.0059967 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.46200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.96200562 42.92200089 Tm [(pa)1(thw)1(ay,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.58999634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.08999634 42.92200089 Tm [(conve)-1(rt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.65701294 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.15701294 42.92200089 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ho)1(spho)1(panto)1(thenoylc)-1(ysteine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.16100311 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.66099548 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.73599243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.23599243 58.52199936 Tm [(4-prime-p)1(hosp)1(hopa)1(ntetheine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.38500977 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.88500977 58.52199936 Tm [(\(Da)1(u)-1(g)1(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rt)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.55300045 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.0529995 74.12200165 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.51199913 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.01199913 74.12200165 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.71500015 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21500015 74.12200165 Tm [(20)-1(02)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.3259964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.8259964 74.12200165 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.28900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.78900146 74.12200165 Tm [(11)-1(92)-1(33)-1(12]\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.19000244 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 0.75 m 103 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 17.10000038 m 103 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 33.45000076 m 103 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 49.80000305 m 103 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 66.15000153 m 103 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 82.5 m 103 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 98.84999847 m 103 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103 115.19999695 m 103 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>