%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 81.78600311 23.67700005 Tm 0 g [(POLR3F)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.80900574 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 333.51300049 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(POLR3F)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.76300049 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.76300049 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(POLR3F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.63800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.01200104 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.21400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.58799744 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.56799316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.94200134 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.41600037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RPC6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.85500336 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.22899628 12.82499981 Tm [(RPC39)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.59700012 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 263.62799072 1.25 l 263.62799072 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 263.62799072 1.25 m 266.29098511 1.25 l 266.29098511 16.68799973 l 263.62799072 16.68799973 l h f* Q q /GS2 gs 1 g 266.29098511 1.25 m 293.36099243 1.25 l 293.36099243 16.68799973 l 266.29098511 16.68799973 l h f* Q q /GS2 gs 1 g 293.36099243 1.25 m 296.02398682 1.25 l 296.02398682 16.68799973 l 293.36099243 16.68799973 l h f* Q q /GS2 gs 1 g 296.02398682 1.25 m 317.82998657 1.25 l 317.82998657 16.68799973 l 296.02398682 16.68799973 l h f* Q q /GS2 gs 1 g 317.82998657 1.25 m 320.49298096 1.25 l 320.49298096 16.68799973 l 317.82998657 16.68799973 l h f* Q q /GS2 gs 1 g 320.49301147 1.25 m 329.33502197 1.25 l 329.33502197 16.68799973 l 320.49301147 16.68799973 l h f* Q q /GS2 gs 1 g 329.33499146 1.25 m 331.99798584 1.25 l 331.99798584 16.68799973 l 329.33499146 16.68799973 l h f* Q q /GS2 gs 1 g 331.99798584 1.25 m 362.03900146 1.25 l 362.03900146 16.68799973 l 331.99798584 16.68799973 l h f* Q q /GS2 gs 1 g 362.03900146 1.25 m 364.70199585 1.25 l 364.70199585 16.68799973 l 362.03900146 16.68799973 l h f* Q q /GS2 gs 1 g 364.70199585 1.25 m 398.0960083 1.25 l 398.0960083 16.68799973 l 364.70199585 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(1-31)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.62799072 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.29098511 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.36099243 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.02398682 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.82998657 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.49301147 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.33499146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.99798584 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.03900146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 364.70199585 12.89099979 Tm [(POLR3F)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 398.0960083 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52499962 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.02499962 11.72200012 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.8769989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.3769989 11.72200012 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.31400299 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.81400299 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.11399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.61399841 11.72200012 Tm [(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.39500427 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RPC6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.84700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.34700012 11.72200012 Tm [(RPC39)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.30500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(1D9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.98400116 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(58)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 116.77500153 109.94999695 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.53999329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.03999329 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.88200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.38200378 11.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.08000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.58000183 11.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.99499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.49499512 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.47000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.97000122 11.72200012 Tm [(do)1(zen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.02600098 11.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ubunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.29999924 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.79999924 27.3220005 Tm [(fo)1(rmin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.20899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.70899963 27.3220005 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.41899872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.91899872 27.3220005 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.44400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.94400024 27.3220005 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.79600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.29600525 27.3220005 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.23300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.73300171 27.3220005 Tm [(\(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.26400757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.76400757 27.3220005 Tm [(Pol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.38699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.88699341 27.3220005 Tm [(III\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.4960022 27.3220005 Tm [(wh)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 42.92200089 Tm [(tr)1(ansc)-1(rib)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.88299942 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.38299942 42.92200089 Tm [(5S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.85500336 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.35500336 42.92200089 Tm [(ribo)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.34700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.84700012 42.92200089 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.37199402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.87199402 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.14900208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.64900208 42.92200089 Tm [(tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.5269928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.0269928 42.92200089 Tm [(gene)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.875 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.375 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.63699341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.13699341 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.44400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.94400024 42.92200089 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.62600708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.50699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.00699997 58.52199936 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08800125 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.58800125 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.66300201 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.16300201 58.52199936 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.60900116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.10900116 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.47299957 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.97299957 58.52199936 Tm [(TFIIIB)-1(90)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.05299377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.55299377 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.83000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.33000183 58.52199936 Tm [(TB)-1(P)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.80900574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.30900574 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.49000549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.99000549 58.52199936 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.45599365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.95599365 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.79800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.29800415 58.52199936 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.82299805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.85200119 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.35200119 74.12200165 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.28900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.78900146 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.3730011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.8730011 74.12200165 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.94700623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.44700623 74.12200165 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.56599426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.06599426 74.12200165 Tm [(IIIB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.64900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.14900208 74.12200165 Tm [(\(TFIIIB)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.85099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.35099792 74.12200165 Tm [(Unlike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.41299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.91299438 74.12200165 Tm [(mos)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.69499969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.19499969 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.19599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.69599915 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.85499954 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.35500336 89.72200012 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.87999725 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.37999725 89.72200012 Tm [(Pol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.00299835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.50299835 89.72200012 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.44000244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.94000244 89.72200012 Tm [(subunits,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.57200623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.07200623 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.07299805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.57299805 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.08000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.58000183 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.88699341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.38699341 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.94799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.44799805 89.72200012 Tm [(uni)-1(q)1(ue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.34399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.03100014 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.53099823 105.3219986 Tm [(po)1(l)-1(ymerase.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.5490036 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.0490036 105.3219986 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.77200317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.27200317 105.3219986 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.18699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.68699646 105.3219986 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.85600281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.35600281 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.29699707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.79699707 105.3219986 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.16900635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.66900635 105.3219986 Tm [(tr)1(ansc)-1(rip)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 0.75 m 116.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 17.10000038 m 116.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 33.45000076 m 116.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 49.80000305 m 116.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 66.15000153 m 116.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 82.5 m 116.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 98.84999847 m 116.40000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 115.19999695 m 116.40000153 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>