%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.66400146 23.67700005 Tm 0 g [(PD)-1(AP1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.93200684 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.63598633 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(PDA)1(P1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.83100128 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.83099365 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PDA)1(P1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.70600128 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.08000183 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.28199768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.65600586 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.63600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.00999451 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.48399353 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PA)1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.73400116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.10800171 12.82499981 Tm [(PA)1(P1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.16300201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.53700256 12.82499981 Tm [(HASPP)1(28)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.47099304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 263.62799072 1.25 l 263.62799072 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 263.62799072 1.25 m 266.29098511 1.25 l 266.29098511 16.68799973 l 263.62799072 16.68799973 l h f* Q q /GS2 gs 1 g 266.29098511 1.25 m 293.36099243 1.25 l 293.36099243 16.68799973 l 266.29098511 16.68799973 l h f* Q q /GS2 gs 1 g 293.36099243 1.25 m 296.02398682 1.25 l 296.02398682 16.68799973 l 293.36099243 16.68799973 l h f* Q q /GS2 gs 1 g 296.02398682 1.25 m 317.82998657 1.25 l 317.82998657 16.68799973 l 296.02398682 16.68799973 l h f* Q q /GS2 gs 1 g 317.82998657 1.25 m 320.49298096 1.25 l 320.49298096 16.68799973 l 317.82998657 16.68799973 l h f* Q q /GS2 gs 1 g 320.49301147 1.25 m 329.33502197 1.25 l 329.33502197 16.68799973 l 320.49301147 16.68799973 l h f* Q q /GS2 gs 1 g 329.33499146 1.25 m 331.99798584 1.25 l 331.99798584 16.68799973 l 329.33499146 16.68799973 l h f* Q q /GS2 gs 1 g 331.99798584 1.25 m 362.03900146 1.25 l 362.03900146 16.68799973 l 331.99798584 16.68799973 l h f* Q q /GS2 gs 1 g 362.03900146 1.25 m 364.70199585 1.25 l 364.70199585 16.68799973 l 362.03900146 16.68799973 l h f* Q q /GS2 gs 1 g 364.70199585 1.25 m 394.18099976 1.25 l 394.18099976 16.68799973 l 364.70199585 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(1-18)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.62799072 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.29098511 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.36099243 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.02398682 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.82998657 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.49301147 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.33499146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.99798584 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.03900146 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 364.70199585 12.89099979 Tm [(PDA)1(P1)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 394.18099976 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PDG)1(FA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.16799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.66799927 11.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.79499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.29499817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.60199738 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.10199738 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.37999725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PA)1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.51199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.01199913 11.72200012 Tm [(PA)1(P1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.80199814 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.30199814 11.72200012 Tm [(HASPP28)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q13)-1(44)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(00)-1(68)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.77500153 16.35000038 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 116.02500153 0.75 l 116.02500153 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 117.02500153 -0.25 l 117.02500153 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.77500153 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 116.77500153 63.15000153 l h f* Q q 1 0 0 1 116.40000153 0 cm -0.625 -0.25 m 310.7749939 -0.25 l 310.7749939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(ph)1(osph)1(opro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.13600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.63600159 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.85800171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.35800171 11.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.5289917 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(upregulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.96900177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.46900177 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.47000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.97000122 27.3220005 Tm [(PDG)1(FA-st)1(imul)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.51100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.01100159 27.3220005 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.92700195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.42700195 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.26899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.76899719 27.3220005 Tm [(fib)1(roblas)1(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.99299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.49299622 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.76998901 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.26998901 27.3220005 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.52700806 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.02700806 27.3220005 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ow)1(n)-1(r)1(e)-1(g)1(u)-1(la)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.04800034 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.54800034 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.5490036 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.0490036 42.92200089 Tm [(mito)1(gen)-1(icity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.78100586 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.28100586 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.1230011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.6230011 42.92200089 Tm [(PDG)1(FB)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.27200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.77200317 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.57899475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.07899475 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.08599854 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.39300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.89300537 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.83401489 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.33401489 42.92200089 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(od)1(e)-1(nts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.64999962 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.15000153 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.83200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.33200073 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.83899689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.33899689 58.52199936 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.41999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.91999817 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.99500275 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.49500275 58.52199936 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.94099426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44099426 58.52199936 Tm [(PDG)1(FA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.60899353 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10899353 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.50500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.00500488 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.97999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.47999573 58.52199936 Tm [(low)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.70300293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.20300293 58.52199936 Tm [(af)1(fini)-1(t)1(y.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.0369873 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 0.75 m 116.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 17.10000038 m 116.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 33.45000076 m 116.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 49.80000305 m 116.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 66.15000153 m 116.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 82.5 m 116.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 98.84999847 m 116.40000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.40000153 115.19999695 m 116.40000153 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 426.92498779 177.9750061 l S Q Q q 1 0 0 1 0 561.47900391 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>