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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.41200256 23.67700005 Tm 0 g [(FMNL2)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.18299866 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.88699341 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(FMNL2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.44100189 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.44099426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FMNL2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.31600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.69000244 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.89199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.26600647 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.2460022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.61999512 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.09399414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FH)-1(OD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.09999847 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 47.37799835 l -0.75 47.37799835 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 33.54199982 1.25 l 33.54199982 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 33.54199982 1.25 m 64.84899902 1.25 l 64.84899902 16.68799973 l 33.54199982 16.68799973 l h f* Q q /GS2 gs 1 g 64.84899902 1.25 m 70.23500061 1.25 l 70.23500061 16.68799973 l 64.84899902 16.68799973 l h f* Q q /GS2 gs 1 g 70.23500061 1.25 m 133.08599854 1.25 l 133.08599854 16.68799973 l 70.23500061 16.68799973 l h f* Q q /GS2 gs 1 g 133.08599854 1.25 m 138.47200012 1.25 l 138.47200012 16.68799973 l 133.08599854 16.68799973 l h f* Q q /GS2 gs 1 g 138.47200012 1.25 m 147.54699707 1.25 l 147.54699707 16.68799973 l 138.47200012 16.68799973 l h f* Q q /GS2 gs 1 g 147.54699707 1.25 m 152.93299866 1.25 l 152.93299866 16.68799973 l 147.54699707 16.68799973 l h f* Q q /GS2 gs 1 g 152.93299866 1.25 m 157.90800476 1.25 l 157.90800476 16.68799973 l 152.93299866 16.68799973 l h f* Q q /GS2 gs 1 g 157.90800476 1.25 m 163.29400635 1.25 l 163.29400635 16.68799973 l 157.90800476 16.68799973 l h f* Q q /GS2 gs 1 g 163.29400635 1.25 m 191.25601196 1.25 l 191.25601196 16.68799973 l 163.29400635 16.68799973 l h f* Q q /GS2 gs 1 g 191.2559967 1.25 m 196.64199829 1.25 l 196.64199829 16.68799973 l 191.2559967 16.68799973 l h f* Q q /GS2 gs 1 g 196.64199829 1.25 m 228.92399597 1.25 l 228.92399597 16.68799973 l 196.64199829 16.68799973 l h f* Q q /GS2 gs 1 g 228.92399597 1.25 m 234.30999756 1.25 l 234.30999756 16.68799973 l 228.92399597 16.68799973 l h f* Q q /GS2 gs 1 g 234.30999756 1.25 m 255.02099609 1.25 l 255.02099609 16.68799973 l 234.30999756 16.68799973 l h f* Q q /GS2 gs 1 g 255.02099609 1.25 m 260.40698242 1.25 l 260.40698242 16.68799973 l 255.02099609 16.68799973 l h f* Q q /GS2 gs 1 g 260.40701294 1.25 m 301.24502563 1.25 l 301.24502563 16.68799973 l 260.40701294 16.68799973 l h f* Q q /GS2 gs 1 g 301.24499512 1.25 m 306.63098145 1.25 l 306.63098145 16.68799973 l 301.24499512 16.68799973 l h f* Q q /GS2 gs 1 g 306.63101196 1.25 m 333.70101929 1.25 l 333.70101929 16.68799973 l 306.63101196 16.68799973 l h f* Q q /GS2 gs 1 g 333.70098877 1.25 m 339.0869751 1.25 l 339.0869751 16.68799973 l 333.70098877 16.68799973 l h f* Q q /GS2 gs 1 g 339.08700562 1.25 m 360.89300537 1.25 l 360.89300537 16.68799973 l 339.08700562 16.68799973 l h f* Q q /GS2 gs 1 g 360.89300537 1.25 m 366.2789917 1.25 l 366.2789917 16.68799973 l 360.89300537 16.68799973 l h f* Q q /GS2 gs 1 g 366.2789917 1.25 m 375.1210022 1.25 l 375.1210022 16.68799973 l 366.2789917 16.68799973 l h f* Q q /GS2 gs 1 g 375.1210022 1.25 m 380.50698853 1.25 l 380.50698853 16.68799973 l 375.1210022 16.68799973 l h f* Q q /GS2 gs 1 g 380.50698853 1.25 m 410.54797363 1.25 l 410.54797363 16.68799973 l 380.50698853 16.68799973 l h f* Q q /GS2 gs 1 g 410.54800415 1.25 m 413.21099854 1.25 l 413.21099854 16.68799973 l 410.54800415 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.54199982 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.84899902 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.23500061 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.47200012 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.54699707 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.93299866 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.90800476 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.29400635 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.2559967 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.64199829 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.92399597 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.30999756 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02099609 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.40701294 12.89099979 Tm [(88)-1(0-10)-1(59)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.24499512 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.63101196 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.70098877 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 339.08700562 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.89300537 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.2789917 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.1210022 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.50698853 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 410.54800415 12.89099979 Tm [( )] TJ ET EMC /P <> BDC q 1 g 0 19.18899918 m 30.78800011 19.18899918 l 30.78800011 34.6269989 l 0 34.6269989 l h f* Q EMC /P <> BDC BT 1 0 0 -1 0 30.82999802 Tm [(FMNL2)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 30.78800011 30.82999802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 46.37799835 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 46.37799835 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 46.62799835 m 421.6000061 46.62799835 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(fo)1(rmin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.65200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.15200043 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.94800186 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.44800186 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.72600174 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(FH)-1(OD)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.20999908 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(PY)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.10599899 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(36)-1(49)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.42500305 16.35000038 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 101.67500305 0.75 l 101.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 102.67500305 -0.25 l 102.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.42500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 102.42500305 78.75 l h f* Q q 1 0 0 1 102.05000305 0 cm -0.625 -0.25 m 325.125 -0.25 l 325.125 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(fo)1(rmin)-1(-)1(rel)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.34500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.84500122 11.72200012 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.31799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.81799316 11.72200012 Tm [(Formin-relat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.1539917 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.6539917 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.12701416 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.34700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.84700012 27.3220005 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.35400009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.85400009 27.3220005 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.9240036 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.4240036 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.36499786 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.86499786 27.3220005 Tm [(morp)1(hog)1(e)-1(nesis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.8769989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.3769989 27.3220005 Tm [(cy)-1(t)1(oki)-1(nesis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.56900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.06900024 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.3460083 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.8460083 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.25601196 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.75601196 27.3220005 Tm [(po)1(l)-1(a)1(rity.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.70999146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.88100052 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.38100052 42.92200089 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.46199799 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.96199799 42.92200089 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.88400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.38400269 42.92200089 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.95399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.45399475 42.92200089 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.79600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.29600525 42.92200089 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.23599243 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.73599243 42.92200089 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.89599609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.39599609 42.92200089 Tm [(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.83100033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.33100033 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.83800125 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.33800125 58.52199936 Tm [(described)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.32299805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.82299805 58.52199936 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.47000122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.97000122 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.8030014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 58.52199936 Tm [(full-length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.35099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.85099792 58.52199936 Tm [(nature)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.81300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.31300354 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.99499512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.49499512 58.52199936 Tm [(ye)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.71800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.21800232 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.29299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.79299927 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.64700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.14700317 58.52199936 Tm [(determi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ne)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.57600021 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 0.75 m 102.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 17.10000038 m 102.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 33.45000076 m 102.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 49.80000305 m 102.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 66.15000153 m 102.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 82.5 m 102.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 98.84999847 m 102.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.05000305 115.19999695 m 102.05000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 595.01800537 cm Q Q 1 0 0 -1 0 841.90002441 cm
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