%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 110 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.21900177 23.67700005 Tm 0 g [(IL)1(1RL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.37600708 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.37600708 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 331.07998657 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(IL1RL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.31900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.56900024 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.56900024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IL1RL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.81900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19300079 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.39499664 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.76899719 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.74899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.1230011 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.59700012 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Inter)1(l)-1(eukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.41400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.78800201 12.82499981 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.11000061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.48400116 12.82499981 Tm [(re)1(ceptor-l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.29600525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.66999817 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.80099487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.17500305 12.82499981 Tm [(T1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.42300415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.79699707 12.82499981 Tm [(ST)-1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.86999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.2440033 12.82499981 Tm [(DE)-1(R)1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.66299438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.03700256 12.82499981 Tm [(ST)-1(2L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.52398682 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.89801025 12.82499981 Tm [(ST)-1(2V;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.92800903 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.30200195 12.82499981 Tm [(FIT)-1(-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.23498535 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.60900879 12.82499981 Tm [(IL33R)] TJ ET EMC /P <> BDC BT 1 0 0 -1 352.01400757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 260.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 148.06199646 1.25 l 148.06199646 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 148.06199646 1.25 m 150.72499084 1.25 l 150.72499084 16.68799973 l 148.06199646 16.68799973 l h f* Q q /GS2 gs 1 g 150.7250061 1.25 m 186.36500549 1.25 l 186.36500549 16.68799973 l 150.7250061 16.68799973 l h f* Q q /GS2 gs 1 g 186.36500549 1.25 m 189.02799988 1.25 l 189.02799988 16.68799973 l 186.36500549 16.68799973 l h f* Q q /GS2 gs 1 g 189.02799988 1.25 m 204.86099243 1.25 l 204.86099243 16.68799973 l 189.02799988 16.68799973 l h f* Q q /GS2 gs 1 g 204.86099243 1.25 m 207.52398682 1.25 l 207.52398682 16.68799973 l 204.86099243 16.68799973 l h f* Q q /GS2 gs 1 g 207.52400208 1.25 m 234.59399414 1.25 l 234.59399414 16.68799973 l 207.52400208 16.68799973 l h f* Q q /GS2 gs 1 g 234.59399414 1.25 m 237.25698853 1.25 l 237.25698853 16.68799973 l 234.59399414 16.68799973 l h f* Q q /GS2 gs 1 g 237.25700378 1.25 m 259.06298828 1.25 l 259.06298828 16.68799973 l 237.25700378 16.68799973 l h f* Q q /GS2 gs 1 g 259.06298828 1.25 m 261.72598267 1.25 l 261.72598267 16.68799973 l 259.06298828 16.68799973 l h f* Q q /GS2 gs 1 g 261.72601318 1.25 m 270.56802368 1.25 l 270.56802368 16.68799973 l 261.72601318 16.68799973 l h f* Q q /GS2 gs 1 g 270.56799316 1.25 m 273.23098755 1.25 l 273.23098755 16.68799973 l 270.56799316 16.68799973 l h f* Q q /GS2 gs 1 g 273.23098755 1.25 m 303.27197266 1.25 l 303.27197266 16.68799973 l 273.23098755 16.68799973 l h f* Q q /GS2 gs 1 g 303.27200317 1.25 m 305.93499756 1.25 l 305.93499756 16.68799973 l 303.27200317 16.68799973 l h f* Q q /GS2 gs 1 g 305.93499756 1.25 m 334.24899292 1.25 l 334.24899292 16.68799973 l 305.93499756 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.06199646 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.7250061 12.89099979 Tm [(terminal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.36500549 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.02799988 12.89099979 Tm [(25)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.86099243 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.52400208 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.59399414 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.25700378 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.06298828 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.72601318 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.56799316 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.23098755 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.27200317 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.93499756 12.89099979 Tm [(IL1)-1(R)1(L)-1(1)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 334.24899292 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 289.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 373.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 95.72499847 16.35000038 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Interleu)-1(kin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97600174 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.47600174 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.75400162 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.25400162 11.72200012 Tm [(rec)-1(ept)1(or-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.36599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.86599731 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.14399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 95.72499847 16.35000038 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(T1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.60400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.10400009 11.72200012 Tm [(ST2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.90200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.40200043 11.72200012 Tm [(DER)1(4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.02600098 11.72200012 Tm [(ST2)-1(L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.44300079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.94300079 11.72200012 Tm [(ST2)-1(V;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.82700348 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.32700348 11.72200012 Tm [(FIT-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.25100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.75100708 11.72200012 Tm [(IL3)-1(3R)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.44599915 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 95.72499847 16.35000038 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q01)-1(63)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 95.72499847 16.35000038 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(30)-1(97)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 95.72499847 16.35000038 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 95.72499847 16.35000038 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 95.72499847 16.35000038 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 94.97499847 0.75 l 94.97499847 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 95.97499847 -0.25 l 95.97499847 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 95.72499847 0.75 m 426.125 0.75 l 426.125 125.55000305 l 95.72499847 125.55000305 l h f* Q q 1 0 0 1 95.34999847 0 cm -0.625 -0.25 m 331.7749939 -0.25 l 331.7749939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(interle)-1(ukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.97299194 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.47299194 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.75100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.25100708 11.72200012 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ce)-1(pt)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.87899971 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.37900162 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.6269989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.1269989 27.3220005 Tm [(Studies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.64499664 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.14499664 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.98699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.48699951 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.48800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.98800659 27.3220005 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.18299866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.68299866 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.19900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.69900513 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.63999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.13999939 27.3220005 Tm [(mouse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.11300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.61300659 27.3220005 Tm [(sugg)1(e)-1(st)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.32699585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.82699585 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.04901123 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.54901123 27.3220005 Tm [(th)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.08800125 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58800125 42.92200089 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.62200165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.12200165 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.97599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.47599792 42.92200089 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.09600067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.59600067 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.10800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.60800171 42.92200089 Tm [(pro)1(in)-1(f)1(lammat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.06100464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.56100464 42.92200089 Tm [(st)1(i)-1(muli,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.41099548 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.91099548 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.18798828 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.68798828 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.85900879 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.35900879 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.2130127 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.7130127 42.92200089 Tm [(inv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(olved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.70400047 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.20400047 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.14500046 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.64500046 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.64599991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.14599991 58.52199936 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.88700104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.38700104 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.22899628 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.72899628 58.52199936 Tm [(helper)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.06300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.56300354 58.52199936 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.72200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.22200012 58.52199936 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.96400452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.46400452 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.72599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.22599792 58.52199936 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.90800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.40800476 58.52199936 Tm [(interle)-1(ukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.13299561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.63299561 58.52199936 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.91101074 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.41101074 58.52199936 Tm [(rec)-1(ept)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.60300016 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.10299969 74.12200165 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.0739994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.57400131 74.12200165 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.22000122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.72000122 74.12200165 Tm [(\(IL1)-1(R)1(1)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.59400177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.09400177 74.12200165 Tm [(interle)-1(ukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.81900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.31900024 74.12200165 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.59700012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.09700012 74.12200165 Tm [(rec)-1(ept)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.68499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.18499756 74.12200165 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.15600586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.65600586 74.12200165 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.94700623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.44700623 74.12200165 Tm [(\(IL1)-1(R)1(2)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.15400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.65400696 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.93099976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.43099976 74.12200165 Tm [(interle)-1(ukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.15600586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 89.72200012 Tm [(rec)-1(ept)1(or-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.88999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.38999939 89.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.66799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.16799927 89.72200012 Tm [(\(IL1)-1(R)1(L)-1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.4940033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.9940033 89.72200012 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.70500183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.20500183 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.17999268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.67999268 89.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.97900391 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.47900391 89.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.90100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.40100098 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.91700745 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.41699219 89.72200012 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.93301392 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.43301392 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.37399292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.87399292 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.84899902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.34899902 89.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(egion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.52599907 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.02599907 105.3219986 Tm [(map)1(ped)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.79299927 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.29299927 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.36799622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.86799622 105.3219986 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.66299438 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.16299438 105.3219986 Tm [(2q1)-1(2.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.91999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.41999817 105.3219986 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.14300537 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.64300537 105.3219986 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.55801392 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.05801392 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.8999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.3999939 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.85598755 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.35598755 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.87200928 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.16900063 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.66899872 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.61000061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.11000061 120.92199707 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.48200226 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.98200226 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.90399933 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.40400696 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.13999939 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 0.75 m 95.34999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 17.10000038 m 95.34999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 33.45000076 m 95.34999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 49.80000305 m 95.34999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 66.15000153 m 95.34999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 82.5 m 95.34999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 98.84999847 m 95.34999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 95.34999847 115.19999695 m 95.34999847 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.5 0.75 m 426.5 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.875 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.125 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.125 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.125 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.125 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.125 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.125 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.125 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 240.375 m 426.875 240.375 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>