%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.58300018 23.67700005 Tm 0 g [(HSD11B)1(1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 164.01199341 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.71600342 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HS)-1(D11)1(B1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.12799835 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.12800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HS)-1(D11)1(B1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.50299835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.8769989 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.07899475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.45300293 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.43299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.80700684 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.28100586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HDL)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.22599792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.59999847 12.82499981 Tm [(11-DH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.26999664 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.64399719 12.82499981 Tm [(HS)-1(D11)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.92399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.29800415 12.82499981 Tm [(HS)-1(D11)1(B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.28900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.66299438 12.82499981 Tm [(HS)-1(D11)1(L)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.35699463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.73100281 12.82499981 Tm [(CORT)-1(RD2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.39199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.76599121 12.82499981 Tm [(SD)-1(R26)1(C)-1(1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.125 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.49899292 12.82499981 Tm [(11-beta-HSD)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.00799561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 147.01600647 1.25 l 147.01600647 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 147.01600647 1.25 m 149.67900085 1.25 l 149.67900085 16.68799973 l 147.01600647 16.68799973 l h f* Q q /GS2 gs 1 g 149.67900085 1.25 m 177.64100647 1.25 l 177.64100647 16.68799973 l 149.67900085 16.68799973 l h f* Q q /GS2 gs 1 g 177.64100647 1.25 m 180.30400085 1.25 l 180.30400085 16.68799973 l 177.64100647 16.68799973 l h f* Q q /GS2 gs 1 g 180.30400085 1.25 m 212.58599854 1.25 l 212.58599854 16.68799973 l 180.30400085 16.68799973 l h f* Q q /GS2 gs 1 g 212.58599854 1.25 m 215.24899292 1.25 l 215.24899292 16.68799973 l 212.58599854 16.68799973 l h f* Q q /GS2 gs 1 g 215.24899292 1.25 m 235.95999146 1.25 l 235.95999146 16.68799973 l 215.24899292 16.68799973 l h f* Q q /GS2 gs 1 g 235.96000671 1.25 m 238.6230011 1.25 l 238.6230011 16.68799973 l 235.96000671 16.68799973 l h f* Q q /GS2 gs 1 g 238.6230011 1.25 m 268.90600586 1.25 l 268.90600586 16.68799973 l 238.6230011 16.68799973 l h f* Q q /GS2 gs 1 g 268.90600586 1.25 m 271.56900024 1.25 l 271.56900024 16.68799973 l 268.90600586 16.68799973 l h f* Q q /GS2 gs 1 g 271.56900024 1.25 m 298.63900757 1.25 l 298.63900757 16.68799973 l 271.56900024 16.68799973 l h f* Q q /GS2 gs 1 g 298.63900757 1.25 m 301.30200195 1.25 l 301.30200195 16.68799973 l 298.63900757 16.68799973 l h f* Q q /GS2 gs 1 g 301.30200195 1.25 m 323.10800171 1.25 l 323.10800171 16.68799973 l 301.30200195 16.68799973 l h f* Q q /GS2 gs 1 g 323.10800171 1.25 m 325.77099609 1.25 l 325.77099609 16.68799973 l 323.10800171 16.68799973 l h f* Q q /GS2 gs 1 g 325.77099609 1.25 m 334.61300659 1.25 l 334.61300659 16.68799973 l 325.77099609 16.68799973 l h f* Q q /GS2 gs 1 g 334.61300659 1.25 m 337.27600098 1.25 l 337.27600098 16.68799973 l 334.61300659 16.68799973 l h f* Q q /GS2 gs 1 g 337.27600098 1.25 m 367.3170166 1.25 l 367.3170166 16.68799973 l 337.27600098 16.68799973 l h f* Q q /GS2 gs 1 g 367.31698608 1.25 m 369.97998047 1.25 l 369.97998047 16.68799973 l 367.31698608 16.68799973 l h f* Q q /GS2 gs 1 g 369.98001099 1.25 m 410.4710083 1.25 l 410.4710083 16.68799973 l 369.98001099 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.01600647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.67900085 12.89099979 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.30400085 12.89099979 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.58599854 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.24899292 12.89099979 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.6230011 12.89099979 Tm [(25)-1(-)1(2)-1(92)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.90600586 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.56900024 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.63900757 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.30200195 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.10800171 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.77099609 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.61300659 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.27600098 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 367.31698608 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 369.98001099 12.89099979 Tm [(HS)-1(D)1(1)-1(1B)-1(1)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 410.4710083 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(hydro)1(xysteroid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.48100281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.98100281 11.72200012 Tm [(11)-1(-)1(be)-1(t)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.61199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.11199951 11.72200012 Tm [(dehydro)1(gen)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.352005 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.63000488 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 31.95000076 l 108.125 31.95000076 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HDL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.60199928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.10199928 11.72200012 Tm [(11)-1(-)1(DH)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.5340004 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.0340004 11.72200012 Tm [(HS)-1(D)1(1)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.26699829 11.72200012 Tm [(HS)-1(D)1(1)-1(1B)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.64700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.14700317 11.72200012 Tm [(HS)-1(D)1(1)-1(1L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.99899292 11.72200012 Tm [(CORTRD2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.06399536 11.72200012 Tm [(SDR26)-1(C)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.01000977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.51000977 11.72200012 Tm [(11)-1(-)1(be)-1(t)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(-HSD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.18199921 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P28)-1(84)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(59)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.125 0.75 l 426.125 94.34999847 l 108.125 94.34999847 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.375 -0.25 l 319.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(mic)-1(r)1(osomal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.83099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33099365 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.71200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.21200562 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.43399048 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.93399048 11.72200012 Tm [(cat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(alyzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.83099937 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.33099937 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.33200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.83200073 27.3220005 Tm [(conve)-1(rs)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.70800018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.20800018 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.05000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.55000305 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.5510025 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.05099487 27.3220005 Tm [(st)1(re)-1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.44500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.94500732 27.3220005 Tm [(ho)1(rmone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.45199585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.95199585 27.3220005 Tm [(cortiso)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.65400696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.15400696 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.22900391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.72900391 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.73001099 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.23001099 27.3220005 Tm [(inac)-1(t)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.23699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(metab)1(olite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.08599854 42.92200089 Tm [(cortiso)1(n)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.21199799 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.71199799 42.92200089 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.90299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.40299988 42.92200089 Tm [(ad)1(dition,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.46800232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.96800232 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.96899414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.46899414 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.97599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.47599792 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.78300476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.28300476 42.92200089 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.31698608 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.81698608 42.92200089 Tm [(cata)1(l)-1(yze)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.32299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.82299805 42.92200089 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 58.52199936 Tm [(reve)-1(r)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.23099899 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.73099899 58.52199936 Tm [(reaction,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.94400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.44400024 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.44499969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.94499969 58.52199936 Tm [(conve)-1(rs)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.82099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.32099915 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.16299438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.66299438 58.52199936 Tm [(cortiso)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.62199402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.12199402 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.19700623 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.69700623 58.52199936 Tm [(cortiso)1(l.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.56600952 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.06600952 58.52199936 Tm [(Too)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.66900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.16900635 58.52199936 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.05500031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.55500031 74.12200165 Tm [(cortiso)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.25699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.75699997 74.12200165 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.79100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.29100037 74.12200165 Tm [(lead)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.52400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.02400208 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.09899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.59899902 74.12200165 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.92399597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.42399597 74.12200165 Tm [(ob)1(e)-1(sit)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.84399414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.34399414 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.6210022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.1210022 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.09599304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.59599304 74.12200165 Tm [(pa)1(rticu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.36799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.86799622 74.12200165 Tm [(var)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.38900757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.88900757 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.82998657 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.47200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.97200012 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.65399933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.15399933 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.66100311 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.16100311 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.28799438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.78799438 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.18400574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.68400574 89.72200012 Tm [(ob)1(e)-1(sit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.93800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.43800354 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.71499634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.21499634 89.72200012 Tm [(insul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.20399475 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.70399475 89.72200012 Tm [(resista)1(n)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.4670105 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.9670105 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.9079895 89.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 0.75 m 107.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 17.10000038 m 107.75 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 49.05000305 m 107.75 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 65.40000153 m 107.75 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 81.75 m 107.75 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 98.09999847 m 107.75 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 114.44999695 m 107.75 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 130.80000305 m 107.75 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.5 0.75 m 426.5 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.875 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.125 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.125 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.125 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.125 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.125 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.125 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.125 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.875 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