%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 75.42099762 23.67700005 Tm 0 g [(HOMER2)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 163.17399597 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 339.87799072 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(HOMER2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 104.2460022 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 188.2460022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HOMER2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.6210022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.99500275 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.19700623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.57099915 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.55099487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.92500305 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.39900208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CPD;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.29199982 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.66600037 12.82499981 Tm [(ACP)1(D)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.03399658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.40799713 12.82499981 Tm [(VE)-1(SL)-1(-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.07699585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.45100403 12.82499981 Tm [(HOMER-)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.28700256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -0.64999998 270.37298584 cm q -0.75 -0.5 m 422.1000061 -0.5 l 422.1000061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 148.06199646 1.25 l 148.06199646 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 148.06199646 1.25 m 150.72499084 1.25 l 150.72499084 16.68799973 l 148.06199646 16.68799973 l h f* Q q /GS2 gs 1 g 150.7250061 1.25 m 186.36500549 1.25 l 186.36500549 16.68799973 l 150.7250061 16.68799973 l h f* Q q /GS2 gs 1 g 186.36500549 1.25 m 189.02799988 1.25 l 189.02799988 16.68799973 l 186.36500549 16.68799973 l h f* Q q /GS2 gs 1 g 189.02799988 1.25 m 204.86099243 1.25 l 204.86099243 16.68799973 l 189.02799988 16.68799973 l h f* Q q /GS2 gs 1 g 204.86099243 1.25 m 207.52398682 1.25 l 207.52398682 16.68799973 l 204.86099243 16.68799973 l h f* Q q /GS2 gs 1 g 207.52400208 1.25 m 234.59399414 1.25 l 234.59399414 16.68799973 l 207.52400208 16.68799973 l h f* Q q /GS2 gs 1 g 234.59399414 1.25 m 237.25698853 1.25 l 237.25698853 16.68799973 l 234.59399414 16.68799973 l h f* Q q /GS2 gs 1 g 237.25700378 1.25 m 259.06298828 1.25 l 259.06298828 16.68799973 l 237.25700378 16.68799973 l h f* Q q /GS2 gs 1 g 259.06298828 1.25 m 261.72598267 1.25 l 261.72598267 16.68799973 l 259.06298828 16.68799973 l h f* Q q /GS2 gs 1 g 261.72601318 1.25 m 270.56802368 1.25 l 270.56802368 16.68799973 l 261.72601318 16.68799973 l h f* Q q /GS2 gs 1 g 270.56799316 1.25 m 273.23098755 1.25 l 273.23098755 16.68799973 l 270.56799316 16.68799973 l h f* Q q /GS2 gs 1 g 273.23098755 1.25 m 303.27197266 1.25 l 303.27197266 16.68799973 l 273.23098755 16.68799973 l h f* Q q /GS2 gs 1 g 303.27200317 1.25 m 305.93499756 1.25 l 305.93499756 16.68799973 l 303.27200317 16.68799973 l h f* Q q /GS2 gs 1 g 305.93499756 1.25 m 345.125 1.25 l 345.125 16.68799973 l 305.93499756 16.68799973 l h f* Q EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.06199646 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.7250061 12.89099979 Tm [(terminal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.36500549 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.02799988 12.89099979 Tm [(12)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.86099243 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.52400208 12.89099979 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.59399414 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.25700378 12.89099979 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.06298828 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.72601318 12.89099979 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.56799316 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.23098755 12.89099979 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.27200317 12.89099979 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.93499756 12.89099979 Tm [(HOMER2)] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 345.125 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 421.3500061 0.5 m 421.3500061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 421.6000061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 421.6000061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ho)1(me)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.23900032 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.73899841 11.72200012 Tm [(ho)1(molog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.03099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.53099823 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80899811 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CPD)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.54899979 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.04899979 11.72200012 Tm [(ACP)1(D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.93000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.43000031 11.72200012 Tm [(VESL-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.61599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.11599731 11.72200012 Tm [(HOMER-2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.19999695 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9NS)-1(B8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.04800034 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(10)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.125 0.75 l 426.125 94.34999847 l 119.47499847 94.34999847 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.0249939 -0.25 l 308.0249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(ho)1(me)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.01600647 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.0980072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.5980072 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.44000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.94000244 11.72200012 Tm [(dendrit)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.19900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.69900513 11.72200012 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ot)1(e)-1(ins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.45499992 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.95500183 27.3220005 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.74500275 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.24500275 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.08699799 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.58699799 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.04299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.54299927 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.625 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.125 27.3220005 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.80000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.30000305 27.3220005 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.50900269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.00900269 27.3220005 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.28700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.78700256 27.3220005 Tm [(metab)1(otr)1(ophic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.83300781 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.33300781 27.3220005 Tm [(gl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(utama)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.74100113 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.24100113 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.66300201 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.16300201 42.92200089 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.06999969 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.56999969 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.3769989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.8769989 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.38400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.88400269 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.19099426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.69099426 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.2519989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.7519989 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.727005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.227005 42.92200089 Tm [(po)1(stsynapt)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.67498779 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(density)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.08699989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.5870018 58.52199936 Tm [(scaff)1(olding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.05200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.55200195 58.52199936 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.02500153 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.52500153 58.52199936 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.2480011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.7480011 58.52199936 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.66299438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.16299438 58.52199936 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.33200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.83200073 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.772995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.27301025 58.52199936 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.64498901 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.92200089 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.42200089 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.15799713 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.65799713 74.12200165 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.64499664 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14499664 74.12200165 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.27400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.77400208 74.12200165 Tm [(pseudog)1(e)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.50100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.00100708 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.3480072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.8480072 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.35499573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.85499573 74.12200165 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.78601074 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 89.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.56300354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.06300354 89.72200012 Tm [(14)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.78500366 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 0.75 m 119.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 17.10000038 m 119.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 33.45000076 m 119.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 49.80000305 m 119.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 66.15000153 m 119.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 82.5 m 119.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 98.84999847 m 119.09999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 115.19999695 m 119.09999847 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.5 0.75 m 426.5 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.875 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.125 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.125 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.125 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.125 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.125 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.125 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.125 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.875 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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