%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.88400269 23.67700005 Tm 0 g [(PD)-1(E)1(4D)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.71099854 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.41500854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(PDE4D)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.41799927 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.41799927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PDE4D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.79299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.16699982 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.3690033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.74299622 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.7230072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.09700012 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.57099915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DPDE3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.60299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.97699738 12.82499981 Tm [(PDE43;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.44100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.81500244 12.82499981 Tm [(ST)-1(RK)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.04400635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.41799927 12.82499981 Tm [(ACRDYS)-1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.32600403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.69999695 12.82499981 Tm [(HS)-1(P)1(DE)-1(4)1(D)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.66900635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.04299927 12.82499981 Tm [(PDE4DN2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.93600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(209)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(PDE4D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.64898682 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ph)1(osph)1(odiesterase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.7559967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.2559967 11.72200012 Tm [(4D,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.05599976 11.72200012 Tm [(cAMP-s)1(pe)-1(cific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.05200195 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DPD)1(E3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.61000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.11000061 11.72200012 Tm [(PDE)1(4)-1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.14199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.64199829 11.72200012 Tm [(STRK1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.02799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.52799988 11.72200012 Tm [(ACR)1(DYS2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.18200684 11.72200012 Tm [(HS)-1(P)1(DE4D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.94700623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.44700623 11.72200012 Tm [(PDE)1(4)-1(D)1(N2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.48500061 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q08)-1(49)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(08)-1(39)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 119.47499847 16.35000038 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 118.72499847 0.75 l 118.72499847 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 119.72499847 -0.25 l 119.72499847 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.47499847 0.75 m 426.17501831 0.75 l 426.17501831 94.34999847 l 119.47499847 94.34999847 l h f* Q q 1 0 0 1 119.09999847 0 cm -0.625 -0.25 m 308.07501221 -0.25 l 308.07501221 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.56900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.06900024 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91100311 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41100311 11.72200012 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.73500061 11.72200012 Tm [(mammalia)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.29400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.79400635 11.72200012 Tm [(coun)-1(t)1(e)-1(r)1(part)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.69500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.19500732 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.26998901 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.76998901 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.77099609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.27099609 11.72200012 Tm [(fr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(uit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.29399967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.79399967 27.3220005 Tm [(fly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.07299995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.57299995 27.3220005 Tm [('dunc)-1(e')] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.65599823 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.15599823 27.3220005 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.83799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.33799744 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.14499664 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.64499664 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.1519928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.6519928 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.95899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.45899963 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.14100647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.64100647 27.3220005 Tm [(3')-1(,)1(5)-1('-cy)-1(clic)-1(-)1(AMP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.48999023 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.98999023 27.3220005 Tm [(ph)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(osp)1(hod)1(i)-1(est)1(e)-1(ra)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.46600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.96600342 42.92200089 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.43800354 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.93800354 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.21499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.71499634 42.92200089 Tm [(degra)1(des)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.77600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.27600098 42.92200089 Tm [(cAMP,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.58799744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.08799744 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.18499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.68499756 42.92200089 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.69200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.19198608 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.33300781 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.83300781 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.80801392 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.30801392 42.92200089 Tm [(sign)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 58.52199936 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.1780014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.6780014 58.52199936 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.89499664 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.39499664 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.33599854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.83599854 58.52199936 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.20799255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.70799255 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.11799622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.61799622 58.52199936 Tm [(types.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.92199707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.42199707 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.68400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.18400574 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.70001221 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.20001221 58.52199936 Tm [(uses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.18399048 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.68399048 58.52199936 Tm [(dif)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ferent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.66799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.16799927 74.12200165 Tm [(pro)1(moters)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.29100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.79100037 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.86599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.36599731 74.12200165 Tm [(gene)-1(r)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.7519989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.2519989 74.12200165 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.62399292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.12399292 74.12200165 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.64700317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.14700317 74.12200165 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.22799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.72799683 74.12200165 Tm [(tr)1(ansc)-1(ri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.10099983 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.60099983 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.17100143 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.67100143 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.89299774 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.39299774 89.72200012 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.14299774 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.64299774 89.72200012 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.75300598 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.25300598 89.72200012 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.89199829 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 0.75 m 119.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 17.10000038 m 119.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 33.45000076 m 119.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 49.80000305 m 119.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 66.15000153 m 119.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 82.5 m 119.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 98.84999847 m 119.09999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.09999847 115.19999695 m 119.09999847 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92501831 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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