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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.4280014 23.67700005 Tm 0 g [(PD)-1(CD5)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.16799927 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.87200928 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(PDCD5)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.88999939 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.88999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PDCD5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.26499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63899994 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.84100342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.21499634 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.19500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.56900024 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.04299927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TF)-1(A)1(R19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.36100006 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(2-125)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(PDCD5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 387.05801392 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 148.2250061 16.35000038 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(pro)1(gra)1(mme)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30400085 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.71399689 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.21399689 11.72200012 Tm [(deat)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.94599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.44599915 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 148.2250061 16.35000038 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TFAR19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.70399857 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 148.2250061 16.35000038 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O14)-1(73)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 148.2250061 16.35000038 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(51)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 148.2250061 16.35000038 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 148.2250061 16.35000038 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 148.2250061 16.35000038 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.2250061 0.75 m 426.17501831 0.75 l 426.17501831 109.94999695 l 148.2250061 109.94999695 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 279.32501221 -0.25 l 279.32501221 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.69900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.19900513 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75999451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25999451 11.72200012 Tm [(upregulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.98599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.48599243 11.72200012 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.92300415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42300415 11.72200012 Tm [(ap)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(op)1(tosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.27099991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.77099991 27.3220005 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.06800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.56800079 27.3220005 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.31600189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.81600189 27.3220005 Tm [(tr)1(ansloc)-1(a)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.52200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.02200317 27.3220005 Tm [(rap)1(idly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.49200439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.99200439 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.70300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.20300293 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.20399475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.70399475 27.3220005 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.77200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.27200317 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.34698486 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 42.92200089 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.48600006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.98600006 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.79299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.29299927 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.80000305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.30000305 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.60699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.10699463 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.27799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.77799988 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.63200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.13200378 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.65299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.15299988 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.11399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.61401367 42.92200089 Tm [(reg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ulato)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.42700005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.92700005 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.76900101 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.26900101 58.52199936 Tm [(K\(lysine)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.36599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.86599731 58.52199936 Tm [(ace)-1(t)1(yl)-1(t)1(ransf)1(e)-1(ra)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.35800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.85800171 58.52199936 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.13600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.63600159 58.52199936 Tm [(\(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.61599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.11599731 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.42300415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.92300415 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.29200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.79199219 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.73300171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.75099945 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.25099945 74.12200165 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.7559967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.2559967 74.12200165 Tm [(da)1(mage)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.25800323 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.75800323 74.12200165 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.75500488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.25500488 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.53199768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.03199768 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.44200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.94200134 74.12200165 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.23399353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.73399353 74.12200165 Tm [(control\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.42700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 89.72200012 Tm [(inhibiting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.08300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.58300018 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.49700165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.99700165 89.72200012 Tm [(pro)1(teasome-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.68400574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.18400574 89.72200012 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.1289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.6289978 89.72200012 Tm [(Pseud)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(og)1(e)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.90299988 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.25 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.75 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.25700378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.75700378 105.3219986 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.68800354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.18800354 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.45599365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.95599365 105.3219986 Tm [(chromos)1(ome)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.91700745 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.41700745 105.3219986 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.69500732 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.19500732 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.47200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.97200012 105.3219986 Tm [(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.52799988 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 0.75 m 147.8500061 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 17.10000038 m 147.8500061 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 33.45000076 m 147.8500061 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 49.80000305 m 147.8500061 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 66.15000153 m 147.8500061 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 82.5 m 147.8500061 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 98.84999847 m 147.8500061 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 115.19999695 m 147.8500061 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92501831 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm
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