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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.43699646 23.67700005 Tm 0 g [(PAK6)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 146.15899658 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 322.86300659 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(PA)1(K6)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.90200043 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.9019928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PA)1(K6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.27700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65100098 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.85299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.22699738 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.20700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.58099365 12.82499981 Tm [(Pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.66600037 12.82499981 Tm [(otein)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.05499268 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PA)1(K5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.27700043 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(407-6)1(58)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(PA)1(K6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.7130127 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(p21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.30400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.80400085 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.11100006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.61100006 11.72200012 Tm [(\(Cdc42)-1(/Rac\)-activa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.72200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.22200012 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.30999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80999756 11.72200012 Tm [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PA)1(K5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.82999992 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9NQU5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.26100159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(35)-1(59)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 110.375 109.94999695 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.25100708 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.33299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.83299255 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.67500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.17500305 11.72200012 Tm [(p21)-1(-)1(stimulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.85101318 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.35101318 11.72200012 Tm [(serine)-1(/t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(hreonine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.39899826 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.89899826 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.20600128 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.70600128 27.3220005 Tm [(ki)-1(na)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.12599945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.62599945 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.7230072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.2230072 27.3220005 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.27200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.77200317 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.29299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.79299927 27.3220005 Tm [(amino-)1(termin)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.39700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.89700317 27.3220005 Tm [(Cdc42)-1(/R)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.48799992 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.98799992 42.92200089 Tm [(interactive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.89099884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.39099884 42.92200089 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.53500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.03500366 42.92200089 Tm [(\(CRIB\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.23500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.73500061 42.92200089 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.56199646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.06199646 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.33900452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.83900452 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.81399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.31399536 42.92200089 Tm [(carbo)1(xy)-1(l-)1(terminal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.96099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.46099854 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.54901123 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(do)1(main.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.99399948 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.49399948 58.52199936 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.5739975 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.0739975 58.52199936 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.32800293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.82800293 58.52199936 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06900024 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.00999451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.50999451 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.48500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.98500061 58.52199936 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.80099487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.30099487 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.14300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.64300537 58.52199936 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.40499878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.90499878 58.52199936 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.20199585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.70199585 58.52199936 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.45500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.95500183 74.12200165 Tm [(cy)-1(t)1(oske)-1(leton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.60099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.10099792 74.12200165 Tm [(rearra)1(n)-1(g)1(e)-1(ment,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.47999573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.97999573 74.12200165 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.14100647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.64100647 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.91799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.41799927 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.41900635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.91900635 74.12200165 Tm [(mito)1(gen)-1(-)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ctivat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.17599869 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.67599869 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.98300171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.48300171 89.72200012 Tm [(\(MAP)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.1269989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6269989 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.71499634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.21499634 89.72200012 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.14599609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.64599609 89.72200012 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.27400208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.77400208 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.58099365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.08099365 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.38800049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.88800049 89.72200012 Tm [(en)-1(cod)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.875 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.375 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.83100128 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.33100128 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.84700012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.34700012 105.3219986 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.19100189 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.69100189 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.08700562 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.58700562 105.3219986 Tm [(andr)1(ogen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.43200684 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.93200684 105.3219986 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.35400391 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.85400391 105.3219986 Tm [(\(AR)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.07400513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.57400513 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.85101318 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.35101318 105.3219986 Tm [(tr)1(ansloc)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 0.75 m 110 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 17.10000038 m 110 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 33.45000076 m 110 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 49.80000305 m 110 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 66.15000153 m 110 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 82.5 m 110 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 98.84999847 m 110 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 115.19999695 m 110 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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