%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 104 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.43699646 23.67700005 Tm 0 g [(PAK4)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 146.15899658 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 322.86300659 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(PA)1(K4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.90200043 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.9019928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PA)1(K4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.27700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65100098 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.85299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.22699738 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.20700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.58099365 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.05499268 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016001700180019000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 236.83399963 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(321-5)1(72)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(PA)1(K4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.7130127 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 265.77301025 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 293.71200562 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 321.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 349.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 124.02500153 0.75 l 124.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.02500153 -0.25 l 125.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.77500153 16.35000038 l h f* Q q 1 0 0 1 124.40000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(p21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.30400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.80400085 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.11100006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.61100006 11.72200012 Tm [(\(Cdc42)-1(/Rac\)-activa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.72200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.22200012 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.30999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80999756 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 124.02500153 0.75 l 124.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.02500153 -0.25 l 125.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.77500153 16.35000038 l h f* Q q 1 0 0 1 124.40000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O96)-1(01)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 124.02500153 0.75 l 124.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.02500153 -0.25 l 125.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.77500153 16.35000038 l h f* Q q 1 0 0 1 124.40000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(11)-1(36)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 124.02500153 0.75 l 124.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.02500153 -0.25 l 125.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.77500153 16.35000038 l h f* Q q 1 0 0 1 124.40000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 124.02500153 0.75 l 124.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.02500153 -0.25 l 125.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.77500153 16.35000038 l h f* Q q 1 0 0 1 124.40000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 124.02500153 0.75 l 124.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.02500153 -0.25 l 125.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 124.77500153 16.35000038 l h f* Q q 1 0 0 1 124.40000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 124.02500153 0.75 l 124.02500153 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 125.02500153 -0.25 l 125.02500153 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.77500153 0.75 m 426.17498779 0.75 l 426.17498779 172.3500061 l 124.77500153 172.3500061 l h f* Q q 1 0 0 1 124.40000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PA)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.55200005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.05200005 11.72200012 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.69100189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.19100189 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.16600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.66600037 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.2480011 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.08999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.58999634 11.72200012 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.94400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.44400024 11.72200012 Tm [(p21)-1(-)1(activat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.6269989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.12701416 11.72200012 Tm [(ki)-1(na)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.54699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(inc)-1(lude)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.25799942 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.75799942 27.3220005 Tm [(PA)1(K1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.75400162 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.2539978 27.3220005 Tm [(PA)1(K2)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.25 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.75 27.3220005 Tm [(PA)1(K3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.58000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.08000183 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.35699463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.85699463 27.3220005 Tm [(PA)1(K4)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.85299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.35299683 27.3220005 Tm [(PA)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.90499878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.40499878 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.87800598 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.37800598 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.89599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.39599609 27.3220005 Tm [(critic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.37200928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.87200928 27.3220005 Tm [(ef)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(fec)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.41699982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.91699982 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.13899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.63899994 42.92200089 Tm [(link)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.875 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.375 42.92200089 Tm [(Rho)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.51399994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.01399994 42.92200089 Tm [(GTPa)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.78500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.28500366 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.36000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.86000061 42.92200089 Tm [(cy)-1(t)1(oske)-1(leton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.5059967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.0059967 42.92200089 Tm [(reorg)1(ani)-1(z)1(at)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.79501343 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.29501343 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.57199097 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.51799965 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.01800156 58.52199936 Tm [(signaling.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.11599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.61599731 58.52199936 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.18699646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.68699646 58.52199936 Tm [(serve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.227005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.727005 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.86799622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.36799622 58.52199936 Tm [(ta)1(rgets)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.51400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.01400757 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.29200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.79200745 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.79299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.29299927 58.52199936 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.65699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.15699768 58.52199936 Tm [(GTP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.51501465 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.01501465 58.52199936 Tm [(bindin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.72999954 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.22999954 74.12200165 Tm [(Cdc42)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.0759964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.5759964 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.85299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.35299683 74.12200165 Tm [(Rac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.71600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.21600342 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.49299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.99299622 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.33999634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.83999634 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.34700012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.84700012 74.12200165 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.91700745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.41700745 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.35800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.85800171 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.83300781 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.33300781 74.12200165 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.69699097 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.19699097 74.12200165 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ange)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.38400078 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.88400078 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.72600174 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.22600174 89.72200012 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.24199677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.74199677 89.72200012 Tm [(activit)1(i)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.28399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.78399658 89.72200012 Tm [(PA)1(K4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.61399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.11399841 89.72200012 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.95799255 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.45799255 89.72200012 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.94299316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.44299316 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.83898926 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.33898926 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.33999634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(GTP-)1(bound)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.56999969 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.06999969 105.3219986 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.78099823 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.28099823 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.1230011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.6230011 105.3219986 Tm [(Cdc42)-1(Hs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.59599304 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.09599304 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.3730011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.8730011 105.3219986 Tm [(weakly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.1190033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.6190033 105.3219986 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.17900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.67900085 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.67999268 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.17999268 105.3219986 Tm [(JNK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.77398682 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.27398682 105.3219986 Tm [(fa)1(mi)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.1060009 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.6060009 120.92199707 Tm [(MAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.23799896 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.73799896 120.92199707 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.15799713 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.65799713 120.92199707 Tm [(PA)1(K4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.48799896 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98799896 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.5490036 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.0490036 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.02400208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.52400208 120.92199707 Tm [(mediat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.70100403 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.20100403 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.04299927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.54299927 120.92199707 Tm [(filop)1(odia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.77099609 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.27099609 120.92199707 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.97299194 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.47299194 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 136.52200317 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.4279995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9280014 136.52200317 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.80899811 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.30899811 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.2840004 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.78399658 136.52200317 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.44400024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.94400024 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.88500214 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.38500214 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.38600159 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.88600159 136.52200317 Tm [(reorg)1(ani)-1(z)1(at)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.67500305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.17500305 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.01699829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.51699829 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.51800537 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.01800537 136.52200317 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.80000305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.30000305 136.52200317 Tm [(cy)-1(t)1(oske)-1(leto)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.71199989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.21199989 152.12199402 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.94400024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.44400024 152.12199402 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.96700287 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.46700287 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.54800415 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.04800415 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.97000122 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.47000122 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.03999329 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.53999329 152.12199402 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.88198853 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.38198853 152.12199402 Tm [(dist)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.4119997 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.91200066 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.0719986 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.5719986 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.91899872 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.41899872 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.9260025 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.4260025 167.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.11599731 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.61599731 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.89399719 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.39399719 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.8500061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.3500061 167.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.03199768 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.40000153 0.75 m 124.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.40000153 17.10000038 m 124.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.40000153 33.45000076 m 124.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.40000153 49.80000305 m 124.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.40000153 66.15000153 m 124.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.40000153 82.5 m 124.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.40000153 98.84999847 m 124.40000153 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 270.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 270.82501221 m 426.92498779 270.82501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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