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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.59300232 23.67700005 Tm 0 g [(OASL)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 146.00300598 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 322.70700073 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(OASL)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.89099884 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.89100647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(OASL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.26599884 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.63999939 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.84200287 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.21600342 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.19599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.57000732 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.04400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(OASL)-1(d,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.40299988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.77700043 12.82499981 Tm [(TRIP14)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.9280014 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30200195 12.82499981 Tm [(TRIP-14,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.04200745 12.82499981 Tm [(p59OASL)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.08799744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.46200562 12.82499981 Tm [(p59)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.62199402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.9960022 12.82499981 Tm [(OASL)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.88200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.25601196 12.82499981 Tm [(p59-OASL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.89700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(207)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(OASL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.12200928 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.32499695 16.35000038 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(2')-1(-)1(5)-1('-olig)1(oadenyl)-1(a)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.9240036 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.4240036 11.72200012 Tm [(syntheta)1(se)-1(-)1(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.19099426 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.32499695 16.35000038 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(OASLd,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.90299988 11.72200012 Tm [(TRIP14)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.81199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.31199646 11.72200012 Tm [(TRIP-)1(1)-1(4,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.11399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.61399841 11.72200012 Tm [(p59)-1(O)1(ASL,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.06399536 11.72200012 Tm [(p59)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.36799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.86799622 11.72200012 Tm [(OASL,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.51400757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.01400757 11.72200012 Tm [(p59)-1(-)1(OASL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.69099426 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.32499695 16.35000038 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q15)-1(64)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.32499695 16.35000038 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(17)-1(40)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.32499695 16.35000038 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.32499695 16.35000038 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 101.32499695 16.35000038 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 100.57499695 0.75 l 100.57499695 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 101.57499695 -0.25 l 101.57499695 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 101.32499695 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 101.32499695 94.34999847 l h f* Q q 1 0 0 1 100.94999695 0 cm -0.625 -0.25 m 326.2250061 -0.25 l 326.2250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(OASL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.47999954 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.97999954 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.89699936 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.39700317 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.91799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.41799927 11.72200012 Tm [(interferon-induce)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.69900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.19900513 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.5059967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.0059967 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.22799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.72799683 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.28900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.78900146 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.76400757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.26400757 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52801514 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.02801514 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.86999512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.36999512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.3710022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(2-5A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.78199959 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.28199959 27.3220005 Tm [(syntheta)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.35900116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.85900116 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.10700226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.60700226 27.3220005 Tm [(2-prime,5-p)1(rime)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.35499573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.85499573 27.3220005 Tm [(oligo)1(adeny)-1(la)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.98800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.48800659 27.3220005 Tm [(\(2-5As\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.44699097 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.94699097 27.3220005 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.39300537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.85199928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.35200119 42.92200089 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.7460022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.2460022 42.92200089 Tm [(RNas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.68499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.18499756 42.92200089 Tm [(L,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.97000122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.47000122 42.92200089 Tm [(resulting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.17100525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.67100525 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.61199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.11199951 42.92200089 Tm [(gene)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.43400574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.93400574 42.92200089 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.45899963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.95899963 42.92200089 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.73699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.23699951 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.51400757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.01400757 42.92200089 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(onsequen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.84799957 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.34799957 58.52199936 Tm [(inhibitio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.38400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.88400269 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.72599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.22599792 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.53300476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.03300476 58.52199936 Tm [(synthesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.40299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.90299988 58.52199936 Tm [(2-5As)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.85099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.35099792 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.8690033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.3690033 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.95401001 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.45401001 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.96600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.46600342 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.44100952 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.94100952 58.52199936 Tm [(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ell)-1(-)1(c)-1(o)1(n)-1(served)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.86700058 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.36700058 74.12200165 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.4489975 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.9489975 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.79100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.29100037 74.12200165 Tm [(interferon-induce)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.57200623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.07200623 74.12200165 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.78500366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.28500366 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.28599548 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.78599548 74.12200165 Tm [(2-5A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.56799316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.06799316 74.12200165 Tm [(syntheta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.43799973 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.93799973 89.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.09600067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.59600067 89.72200012 Tm [(OASs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.6230011 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 0.75 m 100.94999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 17.10000038 m 100.94999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 33.45000076 m 100.94999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 49.80000305 m 100.94999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 66.15000153 m 100.94999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 82.5 m 100.94999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 98.84999847 m 100.94999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 100.94999695 115.19999695 m 100.94999695 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm
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