%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.28800201 23.67700005 Tm 0 g [(NRN)1(1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.30700684 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.01098633 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(NR)1(N1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.20400238 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.20399475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NR)1(N1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.57900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.95300293 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.15499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.52899933 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.50900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.88299561 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.35699463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NR)1(N;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.06600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.44000244 12.82499981 Tm [(dJ380B8.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.2749939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(28-14)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(NR)1(N1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 387.69299316 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.07499695 16.35000038 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ne)-1(urit)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.32400131 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.82400131 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.10200119 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.07499695 16.35000038 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NRN;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.6760006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.1760006 11.72200012 Tm [(dJ380)-1(B8)-1(.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.6989975 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.07499695 16.35000038 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9NPD7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.07499695 16.35000038 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(02)-1(68)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.07499695 16.35000038 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.07499695 16.35000038 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.07499695 16.35000038 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 129.32499695 0.75 l 129.32499695 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 130.32499695 -0.25 l 130.32499695 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.07499695 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 130.07499695 109.94999695 l h f* Q q 1 0 0 1 129.69999695 0 cm -0.625 -0.25 m 297.4750061 -0.25 l 297.4750061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(ne)-1(urit)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.60099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.10099792 11.72200012 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.34899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.84899902 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.12600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.62600708 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.18701172 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.68701172 11.72200012 Tm [(exp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.73800087 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.23799896 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.17900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.67900085 27.3220005 Tm [(po)1(stmito)1(tic-dif)1(fe)-1(r)1(e)-1(ntia)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.08599854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.58599854 27.3220005 Tm [(ne)-1(uro)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.65400696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.15400696 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.4960022 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.49699402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.99699402 27.3220005 Tm [(developmen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ta)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.72299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.22299957 42.92200089 Tm [(ne)-1(r)1(vous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.47000122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.97000122 42.92200089 Tm [(system)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.95800018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.45800018 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.73500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.23500061 42.92200089 Tm [(ne)-1(uro)1(n)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.50700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.00700378 42.92200089 Tm [(st)1(ruc)-1(tures)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.63000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.13000488 42.92200089 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.25700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.75700378 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.15301514 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.65301514 42.92200089 Tm [(plas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ticity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77300072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.27300072 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.2140007 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.7140007 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.71500015 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.21500015 58.52199936 Tm [(ad)1(u)-1(lt)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.40699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.90699768 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.71399689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.21399689 58.52199936 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.16799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.66799927 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.50999451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.00999451 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.46600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.96600342 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.48199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.98199463 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.01600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.51600647 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.36999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.86999512 58.52199936 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.48999023 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 74.12200165 Tm [(ne)-1(ura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.01599884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.51599884 74.12200165 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.98799896 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.48799896 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.76499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.26499939 74.12200165 Tm [(ne)-1(uro)1(trop)1(hins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.69599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.19599915 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.00300598 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.50300598 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.00999451 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.50999451 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.81698608 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.31698608 74.12200165 Tm [(cont)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.08200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.58200073 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.55699921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.05699921 89.72200012 Tm [(conse)-1(nsus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.53399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.03399658 89.72200012 Tm [(cl)-1(eava)1(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.58499908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.08499908 89.72200012 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.31799316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.81799316 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.50799561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.00799561 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.94900513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.44900513 89.72200012 Tm [(glyc)-1(o)1(syl)-1(p)1(hosh)1(atid)1(y)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(osit)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.75200081 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.25200081 105.3219986 Tm [(\(GP)1(I\)-anchored)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.59899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.09899902 105.3219986 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.73800659 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23800659 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.04499817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.54499817 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.05200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.55200195 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.85899353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.35899353 105.3219986 Tm [(pro)1(motes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.04598999 105.3219986 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 0.75 m 129.69999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 17.10000038 m 129.69999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 33.45000076 m 129.69999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 49.80000305 m 129.69999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 66.15000153 m 129.69999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 82.5 m 129.69999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 98.84999847 m 129.69999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 129.69999695 115.19999695 m 129.69999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>