%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.08899689 23.67700005 Tm 0 g [(NOS2)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.50700378 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 324.21099854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(NOS2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.50099945 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.50100708 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NOS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.87599945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.25 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.45200348 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.8259964 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.80599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.17999268 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.65400696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NOS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.36399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.73799896 12.82499981 Tm [(IN)1(O)-1(S;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.7480011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.12200165 12.82499981 Tm [(NOS2A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.88299561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.25700378 12.82499981 Tm [(HEP-NOS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.1190033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(2-150)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(NOS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.66900635 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.82499695 16.35000038 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(nitric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.63899994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.13899994 11.72200012 Tm [(oxid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.18099976 11.72200012 Tm [(syntha)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.79799652 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.29799652 11.72200012 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.74199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.24199677 11.72200012 Tm [(induc)-1(ib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.64300537 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.82499695 16.35000038 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NOS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.01199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.51199913 11.72200012 Tm [(INOS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.66999817 11.72200012 Tm [(NOS2)-1(A)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.29299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.79299927 11.72200012 Tm [(HEP-NOS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.94799805 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.82499695 16.35000038 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P35)-1(22)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.82499695 16.35000038 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(30)-1(28)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.82499695 16.35000038 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.82499695 16.35000038 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 130.82499695 16.35000038 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 130.07499695 0.75 l 130.07499695 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 131.07499695 -0.25 l 131.07499695 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 130.82499695 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 130.82499695 109.94999695 l h f* Q q 1 0 0 1 130.44999695 0 cm -0.625 -0.25 m 296.7250061 -0.25 l 296.7250061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Nitr)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.40999985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.90999985 11.72200012 Tm [(oxid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.45199966 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.95199966 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.51300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.01300049 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.98799896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.48799896 11.72200012 Tm [(reactive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.09700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.59700012 11.72200012 Tm [(free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.36700439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.86700439 11.72200012 Tm [(rad)1(ic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.31300354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.81300354 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.91000366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.41000366 11.72200012 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.41700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.91700745 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.05799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.55799866 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.53300476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.03300476 11.72200012 Tm [(biolo)1(gic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.6789856 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mediat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.17699814 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.67699814 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61800003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11800003 27.3220005 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.02700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.52700043 27.3220005 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.82400513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.32400513 27.3220005 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.17399597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.67399597 27.3220005 Tm [(ne)-1(uro)1(transmissio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.32901001 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.82901001 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.10598755 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(antimicrob)1(i)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.28099823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.78099823 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.05799866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.55799866 42.92200089 Tm [(antit)1(umoral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.68600464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.18600464 42.92200089 Tm [(activit)1(i)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.72799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.22799683 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.49000549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.99000549 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.5059967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.0059967 42.92200089 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.92300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.42300415 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.39801025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.89801025 42.92200089 Tm [(ni)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tr)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69799995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 58.52199936 Tm [(oxid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.74000168 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.24000168 58.52199936 Tm [(syntha)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.85700226 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.35700226 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.45400238 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.95400238 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.51499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.01499939 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.16900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.66900635 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.61000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.11000061 58.52199936 Tm [(live)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.16700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.66700745 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.94400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.44400024 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.00500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.50500488 58.52199936 Tm [(induc)-1(ib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.90600586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.98699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.48699951 74.12200165 Tm [(combinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.83399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.33399963 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.1760025 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.6760025 74.12200165 Tm [(lipop)1(olysac)-1(cha)1(ride)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.94200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.44200134 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.71899414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.21899414 74.12200165 Tm [(ce)-1(rt)1(ain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.54400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.04400635 74.12200165 Tm [(cy)-1(t)1(oki)-1(nes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.67498779 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.17498779 74.12200165 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(hree)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.19099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.69099998 89.72200012 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.81999969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.31999969 89.72200012 Tm [(pseudog)1(e)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.04699707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.54699707 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.06500244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.56500244 89.72200012 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.38600159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.88600159 89.72200012 Tm [(wit)1(hin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.22200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.72200012 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.7230072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.2230072 89.72200012 Tm [(Smith-)1(Mageni)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 105.3219986 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.59600067 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 105.3219986 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.05799866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.55799866 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.8259964 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.3259964 105.3219986 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.1210022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.6210022 105.3219986 Tm [(17)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.34300232 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 0.75 m 130.44999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 17.10000038 m 130.44999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 33.45000076 m 130.44999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 49.80000305 m 130.44999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 66.15000153 m 130.44999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 82.5 m 130.44999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 98.84999847 m 130.44999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.44999695 115.19999695 m 130.44999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>