%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.74700165 23.67700005 Tm 0 g [(NME4)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 149.84899902 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 326.55300903 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(NM)1(E)-1(4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.82900238 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.82899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NM)1(E)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.20400238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.57800293 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.77999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.15399933 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.13400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.50799561 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.98199463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NDP)1(K-D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.60099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.97499847 12.82499981 Tm [(NM)1(23H4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.04699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42100525 12.82499981 Tm [(nm23-H4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.04699707 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(34-18)1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(NM)1(E)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.31799316 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.125 16.35000038 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NME/NM2)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.56999969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.06999969 11.72200012 Tm [(nuc)-1(leoside)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.3219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.8219986 11.72200012 Tm [(dip)1(hosp)1(hat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.875 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.375 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.46299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.96299744 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.24099731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.125 16.35000038 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NDPK)1(-D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.30699921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.80699921 11.72200012 Tm [(NM23)-1(H4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.87799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.37799835 11.72200012 Tm [(nm2)-1(3-H4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.04499817 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.125 16.35000038 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O00)-1(74)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.125 16.35000038 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(17)-1(06)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.125 16.35000038 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.125 16.35000038 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.125 16.35000038 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 110.375 0.75 l 110.375 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 111.375 -0.25 l 111.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.125 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 111.125 94.34999847 l h f* Q q 1 0 0 1 110.75 0 cm -0.625 -0.25 m 316.42498779 -0.25 l 316.42498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(nuc)-1(leoside)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.55899811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.05899811 11.72200012 Tm [(dip)1(hosp)1(hat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.11199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.61199951 11.72200012 Tm [(\(NDP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.30200195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.80200195 11.72200012 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.05599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.55599976 11.72200012 Tm [(\(EC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.53100586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.03100586 11.72200012 Tm [(2.7)-1(.)1(4)-1(.)1(6)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.647995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.147995 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.66598511 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.16598511 11.72200012 Tm [(ubiquito)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.71199989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.21199989 27.3220005 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.75899887 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.25899887 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.48100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.98100281 27.3220005 Tm [(cata)1(l)-1(yze)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.48699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.98699951 27.3220005 Tm [(tr)1(ansfer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.12600708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.62600708 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.46800232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.96800232 27.3220005 Tm [(ga)1(mma-p)1(hosp)1(hat)1(e)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.66699219 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.16699219 27.3220005 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.26098633 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.76098633 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.73599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.23599243 27.3220005 Tm [(ph)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(sph)1(ohist)1(idine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.83200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.33200073 42.92200089 Tm [(intermediate,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.46099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.96099854 42.92200089 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.03300476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.53300476 42.92200089 Tm [(nuc)-1(leoside)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.78500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.28500366 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.56199646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.06199646 42.92200089 Tm [(diox)1(y)-1(nuc)-1(leosid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.51300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tr)1(i)-1(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.07800007 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.57799911 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.85499954 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.35499954 58.52199936 Tm [(dip)1(hosp)1(hat)1(e)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.73999786 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.23999786 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.04699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.54699707 58.52199936 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.09399414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.59399414 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.11199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.61199951 58.52199936 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.35299683 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.19500732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.69500732 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.69599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.1960144 58.52199936 Tm [(nm2)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.73098755 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.23098755 58.52199936 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.85400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.35400009 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.4509964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.9509964 74.12200165 Tm [(inc)-1(ludes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.375 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.875 74.12200165 Tm [(NME4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.21099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.71099854 74.12200165 Tm [(\(Milon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.56799316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.06799316 74.12200165 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.5269928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.0269928 74.12200165 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.72999573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.22999573 74.12200165 Tm [(19)-1(97)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.34100342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.84100342 74.12200165 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.3039856 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.8039856 74.12200165 Tm [(90)-1(99)-1(85)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(0]\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.45600033 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 0.75 m 110.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 17.10000038 m 110.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 33.45000076 m 110.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 49.80000305 m 110.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 66.15000153 m 110.75 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 82.5 m 110.75 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 98.84999847 m 110.75 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.75 115.19999695 m 110.75 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream 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