%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.08599854 23.67700005 Tm 0 g [(NFE)1(2L1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 155.50999451 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 332.21398926 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(NFE2L)-1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.41200256 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.41200256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFE2L)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.78700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.16100311 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.36300659 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.73699951 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.71699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.09100342 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.56500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NR)1(F)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.80899811 12.82499981 Tm [(TC)-1(F11;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.80200195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.1760025 12.82499981 Tm [(LC)-1(R-F1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.25100708 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(250)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(NFE2L)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.64300537 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 127.77500153 16.35000038 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.51799965 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.01800156 11.72200012 Tm [(fa)1(c)-1(t)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.30400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.80400085 11.72200012 Tm [(ery)-1(t)1(hro)1(id)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.31500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.81500244 11.72200012 Tm [(2-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.78300476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.28300476 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.56100464 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 127.77500153 16.35000038 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NRF1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.41799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.91799927 11.72200012 Tm [(TCF1)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.60100174 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.10100174 11.72200012 Tm [(LCR-F1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.56800079 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 127.77500153 16.35000038 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q14)-1(49)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 127.77500153 16.35000038 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(10)-1(62)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 127.77500153 16.35000038 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 127.77500153 16.35000038 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 127.77500153 16.35000038 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 127.02500153 0.75 l 127.02500153 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 128.0249939 -0.25 l 128.0249939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.77500153 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 127.77500153 78.75 l h f* Q q 1 0 0 1 127.40000153 0 cm -0.625 -0.25 m 299.7749939 -0.25 l 299.7749939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.69900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.19900513 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75999451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25999451 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.1289978 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.07000732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.57000732 11.72200012 Tm [(glob)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.13200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.63200378 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.14801025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.64801025 11.72200012 Tm [(ex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.2859993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.7859993 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.72700119 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.22700119 27.3220005 Tm [(ery)-1(t)1(hro)1(c)-1(ytes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.65499878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.15499878 27.3220005 Tm [(Confusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.93800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.43800354 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.11999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.61999512 27.3220005 Tm [(occ)-1(urred)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.6499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.1499939 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.09100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.59100342 27.3220005 Tm [(bib)1(l)-1(io)1(grap)1(hi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.51300001 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.01299953 42.92200089 Tm [(da)1(tab)1(ases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.23300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.73300171 42.92200089 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.14199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.64199829 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.71700287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.21700287 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.21800232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71800232 42.92200089 Tm [(sha)1(re)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.69999695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.19999695 42.92200089 Tm [(symbol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.42799377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.92799377 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.77000427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.27000427 42.92200089 Tm [(NRF1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.52099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.02099609 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.29899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.79899597 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.25500488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.75500488 42.92200089 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.43701172 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(NFE2L)-1(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.38700104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.88700104 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.16400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.66400146 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.94200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.44200134 58.52199936 Tm [("nucl)-1(ear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.87999725 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.37999725 58.52199936 Tm [(respira)1(tory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.91799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.41799927 58.52199936 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.53700256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.03700256 58.52199936 Tm [(1")] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.23500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.73500061 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.83200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.33200073 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.01400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.51400757 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.03500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.53500366 58.52199936 Tm [(of)1(fi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ci)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.27799988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.77799988 74.12200165 Tm [(symbol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.00600052 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.50600052 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.34799957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.84799957 74.12200165 Tm [(NRF1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.26599884 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 0.75 m 127.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 17.10000038 m 127.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 33.45000076 m 127.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 49.80000305 m 127.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 66.15000153 m 127.40000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 82.5 m 127.40000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 98.84999847 m 127.40000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.40000153 115.19999695 m 127.40000153 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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