%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.7440033 23.67700005 Tm 0 g [(NFATC1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 157.85099792 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 334.55499268 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(NFATC1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.08999634 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.08999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFATC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.71499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.08899689 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.29100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.66499329 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.64500427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.01899719 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.49299622 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFAT2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.73600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.11000061 12.82499981 Tm [(NFATc,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.96399689 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.33799744 12.82499981 Tm [(NF-ATC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.94599915 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.43099976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.80499268 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.96000671 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.33399963 12.55799961 Tm [(300)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.29899597 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.67300415 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.55400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.92799377 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.42999268 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.8039856 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.54501343 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.91900635 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.88598633 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.26000977 12.55799961 Tm [(NFATC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.9750061 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 112.67500305 31.95000076 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.51799965 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.01800156 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.13700104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.63700104 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.47899628 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.97899628 11.72200012 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.12999725 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.62999725 11.72200012 Tm [(T-ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.42500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.92500305 11.72200012 Tm [(cy)-1(t)1(oplas)1(mi)-1(c,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.06799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.56799316 11.72200012 Tm [(calc)-1(ineu)-1(rin-)1(de)-1(p)1(e)-1(nd)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 27.3220005 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.67700005 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.67500305 16.35000038 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NFAT2)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.0340004 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.5340004 11.72200012 Tm [(NFATc)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.80400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.30400085 11.72200012 Tm [(NF-A)1(T)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.80799866 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.67500305 16.35000038 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O95)-1(64)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.67500305 16.35000038 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(12)-1(24)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.67500305 16.35000038 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.67500305 16.35000038 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.67500305 16.35000038 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 111.92500305 0.75 l 111.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 112.92500305 -0.25 l 112.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.67500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 112.67500305 94.34999847 l h f* Q q 1 0 0 1 112.30000305 0 cm -0.625 -0.25 m 314.875 -0.25 l 314.875 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.38199997 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.88199997 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.72399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.22399902 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.68000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.18000031 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.69599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.19599915 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.75700378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.25700378 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.23199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.73199463 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.92100525 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.76300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.26300049 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.26400757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.76400757 11.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.28201294 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.78201294 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.90100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.40100098 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.24301147 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.15100098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.65100098 27.3220005 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.81000137 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.31000137 27.3220005 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.88600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.38600159 27.3220005 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.92799377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.42799377 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.01199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.51199341 27.3220005 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.15800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.65800476 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.92001343 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.42001343 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.89898682 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(consists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.02700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.52700043 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.36899948 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.86899948 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.1969986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.6969986 42.92200089 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.69200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.19200134 42.92200089 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.3730011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.8730011 42.92200089 Tm [(components:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.89399719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.39399719 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.3690033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.8690033 42.92200089 Tm [(preexisting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.44000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.94000244 42.92200089 Tm [(cy)-1(t)1(osolic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.48199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.98199463 42.92200089 Tm [(compo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ne)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.5510006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.0510006 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.27299881 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.77299881 58.52199936 Tm [(tr)1(ansloc)-1(a)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.47899628 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.97899628 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.05400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.55400085 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.55499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.05499268 58.52199936 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.8730011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.3730011 58.52199936 Tm [(upon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.93499756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.43499756 58.52199936 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.59399414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.09399414 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.5039978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.0039978 58.52199936 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.42599487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.92599487 58.52199936 Tm [(\(TCR\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.99301147 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.49301147 58.52199936 Tm [(st)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mulatio)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.53099823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.03099823 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.80799866 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.82900238 74.12200165 Tm [(induc)-1(ib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.23000336 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.73000336 74.12200165 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.2480011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.7480011 74.12200165 Tm [(component.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.60299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.10299683 74.12200165 Tm [(Pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.33399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.83401489 74.12200165 Tm [(belonging)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.80599976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.03100014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.53099823 89.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.61299896 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.11299896 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.95500183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.45500183 89.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.03900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.53900146 89.72200012 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.82400513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.32400513 89.72200012 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.20500183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.70500183 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.67999268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.17999268 89.72200012 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.50500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.00500488 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.66499329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.16500854 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.10598755 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.60598755 89.72200012 Tm [(induc)-1(ib)1(l)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 0.75 m 112.30000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 32.70000076 m 112.30000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 49.05000305 m 112.30000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 65.40000153 m 112.30000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 81.75 m 112.30000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 98.09999847 m 112.30000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 114.44999695 m 112.30000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.30000305 130.80000305 m 112.30000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>