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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 70.53900146 23.67700005 Tm 0 g [(NE)1(URO)-1(G3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 168.05700684 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 344.76098633 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(NEU)1(ROG3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.86599731 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 192.86599731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NEU)1(ROG3)] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 106.24099731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 108.61499786 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 141.81700134 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 144.19099426 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 204.17100525 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 206.54499817 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 241.01899719 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 18 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 19 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ngn3;)] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 87.10700226 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 89.48100281 12.82499981 Tm [(Atoh5;)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 118.25900269 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 120.63300323 12.82499981 Tm [(NG)1(N-3;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 152.15899658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 154.53300476 12.82499981 Tm [(Math4B;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 191.41600037 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 193.78999329 12.82499981 Tm [(bHL)-1(Ha7)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 227.15600586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(1-214)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(NEU)1(ROG3)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 401.03399658 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.92500305 16.35000038 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 84 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ne)-1(uro)1(gen)-1(in)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 49.70700073 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 54.20700073 11.72200012 Tm [(3)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 59.48500061 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.92500305 16.35000038 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ngn3;)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 24.29299927 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 28.79299927 11.72200012 Tm [(At)1(oh5;)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 57.18600082 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 61.68600082 11.72200012 Tm [(NGN-)1(3)-1(;)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 94.35099792 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 98.85099792 11.72200012 Tm [(Mat)1(h4B)-1(;)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 134.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 139.10499573 11.72200012 Tm [(bHLH)-1(a)1(7)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 173.64599609 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 100 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 101 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.92500305 16.35000038 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y4Z2)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 34.18099976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 104 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 107 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.92500305 16.35000038 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(17)-1(48)-1(8)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 111 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.92500305 16.35000038 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 112 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 128 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 131 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.92500305 16.35000038 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 132 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 136 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 137 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.92500305 16.35000038 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 138 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 111.17500305 0.75 l 111.17500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 112.17500305 -0.25 l 112.17500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 150 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 151 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.92500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 111.92500305 78.75 l h f* Q q 1 0 0 1 111.55000305 0 cm -0.625 -0.25 m 315.625 -0.25 l 315.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 152 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(ba)1(sic)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 201.43800354 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 205.93800354 11.72200012 Tm [(helix-loo)1(p-h)1(e)-1(lix)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 273.31100464 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 277.81100464 11.72200012 Tm [(\(bHLH)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(\))] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 3.00600004 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 7.50600004 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 62.09000015 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 66.58999634 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 91.70899963 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 96.20899963 27.3220005 Tm [(involved)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 132.57800293 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 137.07800293 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 145.01899719 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 149.51899719 27.3220005 Tm [(ne)-1(uro)1(gen)-1(esis.)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 209.28500366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 213.78500366 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 229.59199524 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 234.09199524 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 271.59899902 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 276.09899902 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 307.40600586 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(lik)-1(ely)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 21.95499992 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 26.45499992 42.92200089 Tm [(acts)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 43.4620018 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 47.9620018 42.92200089 Tm [(as)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 57.10300064 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 61.60300064 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 66.57800293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 71.07800293 42.92200089 Tm [(heterod)1(ime)-1(r)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 124.47200012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 128.97200012 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 147.36799622 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 151.86799622 42.92200089 Tm [(anot)1(her)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 185.54800415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 190.04800415 42.92200089 Tm [(bHLH)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 214.33700562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 218.83700562 42.92200089 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 252.30999756 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 256.80999756 42.92200089 Tm [(Defec)-1(t)1(s)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 289.03100586 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 293.53100586 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 301.47198486 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 15.45600033 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 19.95599937 58.52199936 Tm [(gene)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 41.47200012 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 45.97200012 58.52199936 Tm [(are)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 59.49000168 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 63.99000168 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 68.96499634 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 73.46499634 58.52199936 Tm [(cause)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 97.77100372 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 102.27100372 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 111.11299896 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 115.61299896 58.52199936 Tm [(congen)-1(it)1(al)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 160.92100525 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 165.42100525 58.52199936 Tm [(malab)1(sorp)1(tive)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 226.59700012 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 231.09700012 58.52199936 Tm [(dia)1(rrhea)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 266.71899414 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 271.21899414 58.52199936 Tm [(4)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 276.49700928 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 280.99700928 58.52199936 Tm [(\(DIA)1(R)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(4\).)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 10.44999981 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 0.75 m 111.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 17.10000038 m 111.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 33.45000076 m 111.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 49.80000305 m 111.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 66.15000153 m 111.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 82.5 m 111.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 98.84999847 m 111.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.55000305 115.19999695 m 111.55000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm 
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