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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.11699677 23.67700005 Tm 0 g [(NAPA)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.47900391 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.18301392 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(NA)1(PA)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.97799683 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.97799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NA)1(PA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.35299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.72699738 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.92900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.3030014 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.28300476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.65699768 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.1309967 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SNAP)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.17700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(25-29)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.15301514 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.52700806 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.4079895 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.78201294 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.28399658 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.6579895 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.39898682 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.77301025 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.73999023 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.11401367 12.55799961 Tm [(NA)1(PA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 387.4670105 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(N-eth)1(y)-1(lma)1(l)-1(eimide-sensitive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.21700287 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.71700287 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.83599854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.33599854 11.72200012 Tm [(at)1(tachment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.48399353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.98399353 11.72200012 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.45700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.95700073 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.59100342 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SNAPA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.68300056 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P54)-1(92)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(01)-1(16)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 146.17500305 109.94999695 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(soluble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.35499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.85499573 11.72200012 Tm [(NSF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.14700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.64700317 11.72200012 Tm [(at)1(tachme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.70600128 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.20600128 27.3220005 Tm [(\(SNAP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.56800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.06800079 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.31600189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.81600189 27.3220005 Tm [(SNAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.16600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.66600037 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.13900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.63900757 27.3220005 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.52000427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.02000427 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.99499512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.49499512 27.3220005 Tm [(critic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.47099304 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.97099304 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.63101196 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.44199944 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.94199944 42.92200089 Tm [(do)1(c)-1(kin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.53099823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.03099823 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.30799866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.80799866 42.92200089 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.3030014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.8030014 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.64500427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.14500427 42.92200089 Tm [(vesic)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.71699524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.21699524 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.29200745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.79200745 42.92200089 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.77200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.27200317 42.92200089 Tm [(membranes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.22198486 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.15299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.65299988 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.49499893 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.99499893 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.99599838 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.4960022 58.52199936 Tm [(20)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.2460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.7460022 58.52199936 Tm [(NSF-SNAP-)1(SNARE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.84300232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.34300232 58.52199936 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.98899841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.48899841 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.29600525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.79600525 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.30300903 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 74.12200165 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.85400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.35400009 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.32900238 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.48899841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.98899841 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.93000031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.43000031 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.43099976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.93099976 74.12200165 Tm [(completion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.86399841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.36399841 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.20599365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.70599365 74.12200165 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.49000549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.99000549 74.12200165 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.48498535 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 89.72200012 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.72900009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.22900009 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.23000336 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.73000336 89.72200012 Tm [(interaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.07000732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.57000732 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.41200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.91200256 89.72200012 Tm [(N-eth)1(y)-1(lma)1(l)-1(eimide-sensitive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.1289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.6289978 89.72200012 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(acto)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.99900055 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.49900055 105.3219986 Tm [(\(NSF\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.8030014 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3030014 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.6989975 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.1989975 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.19999695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.69999695 105.3219986 Tm [(vesic)-1(le-as)1(soc)-1(ia)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.1269989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.6269989 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.90400696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.40400696 105.3219986 Tm [(membrane-as)1(soc)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 0.75 m 145.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 17.10000038 m 145.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 33.45000076 m 145.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 49.80000305 m 145.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 66.15000153 m 145.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 82.5 m 145.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 98.84999847 m 145.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 115.19999695 m 145.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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