%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.98000336 23.67700005 Tm 0 g [(NAP1L1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 157.61500549 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 334.31900024 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(NA)1(P1L1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 93.70999908 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.71000671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NA)1(P1L1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.33499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.70899963 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.91099548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.28500366 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.26499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.63900757 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.11300659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NR)1(P,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.52300262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.89700317 12.82499981 Tm [(NA)1(P1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.48999786 12.82499981 Tm [(NA)1(P1L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.5039978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(1-300)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.83200073 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.20599365 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08700562 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.46099854 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.9630127 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.33700562 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.07800293 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.45199585 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.41900635 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.79299927 12.55799961 Tm [(NA)1(P1L1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 391.12799072 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(nuc)-1(leosome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.25500107 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.75500107 11.72200012 Tm [(assembly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.50800323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.00800323 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.31500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.81500244 11.72200012 Tm [(1-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.78300476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.28300476 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.56100464 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NRP,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.86499977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.36499977 11.72200012 Tm [(NAP)1(1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.96500015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.46500015 11.72200012 Tm [(NAP)1(1)-1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.51699829 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P55)-1(20)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(02)-1(38)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.375 16.35000038 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 109.625 0.75 l 109.625 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 110.625 -0.25 l 110.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.375 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 110.375 94.34999847 l h f* Q q 1 0 0 1 110 0 cm -0.625 -0.25 m 317.17498779 -0.25 l 317.17498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(nuc)-1(leosome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.53199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.03199768 11.72200012 Tm [(assembly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.78500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.28500366 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.5920105 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(\(NAP)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.16699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.66699982 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.91500092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.41500092 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.67700195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.17700195 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.48400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.98400116 27.3220005 Tm [(pa)1(rticipat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.147995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.647995 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.58900452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.08900452 27.3220005 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.59399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.09399414 27.3220005 Tm [(replic)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.67800903 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.17800903 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.45498657 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.95498657 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.12600708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.88100052 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.38100052 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.3560009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.8560009 42.92200089 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.51599884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.01599884 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.95700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.45700073 42.92200089 Tm [(mod)1(u)-1(la)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.33499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.83499908 42.92200089 Tm [(chromat)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.75 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.25 42.92200089 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.95199585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.45199585 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.72900391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.22900391 42.92200089 Tm [(contribut)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.94799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.44799805 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.52301025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.02301025 42.92200089 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.8370018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.3370018 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.17900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.67900085 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.08899689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.58899689 58.52199936 Tm [(pro)1(life)-1(r)1(ation.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.10499573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.60499573 58.52199936 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.32800293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.82800293 58.52199936 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.74299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.24299622 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.08500671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.58500671 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.04098511 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.54098511 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.05700684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.55700684 58.52199936 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(sults)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.62599945 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.12599945 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.06700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.56700134 74.12200165 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.47599792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.97599792 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.89800262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.39800262 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.13400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.63400269 74.12200165 Tm [(ho)1(weve)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.54299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.04299927 74.12200165 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.66400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.16400146 74.12200165 Tm [(all)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.92900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.42900085 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.77600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.27600098 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.7829895 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.2829895 74.12200165 Tm [(fully)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.50299072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(described.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.15200043 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 0.75 m 110 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 17.10000038 m 110 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 33.45000076 m 110 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 49.80000305 m 110 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 66.15000153 m 110 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 82.5 m 110 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 98.84999847 m 110 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110 115.19999695 m 110 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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