%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 115 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 81.65200043 23.67700005 Tm 0 g [(MUTYH)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.94400024 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 333.64801025 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(MUTYH)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 98.11499786 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 182.11500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MUTYH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.48999786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.86399841 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.06599426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.44000244 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.41999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.79400635 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.26800537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MYH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.63600159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.43099976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.80499268 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.96000671 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.33399963 12.55799961 Tm [(300)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.29899597 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.67300415 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.55400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.92799377 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.42999268 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.8039856 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.54501343 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.91900635 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.88598633 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.26000977 12.55799961 Tm [(MUTYH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.75 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.875 16.35000038 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(mutY)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.76399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.26399994 11.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.76900101 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.26900101 11.72200012 Tm [(glyc)-1(o)1(syl)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.99099731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.875 16.35000038 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(MYH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.18600082 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.875 16.35000038 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9UIF7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.0359993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.875 16.35000038 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(03)-1(17)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.875 16.35000038 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.875 16.35000038 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.875 16.35000038 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 108.125 0.75 l 108.125 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 109.125 -0.25 l 109.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.875 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 108.875 109.94999695 l h f* Q q 1 0 0 1 108.5 0 cm -0.625 -0.25 m 318.67498779 -0.25 l 318.67498779 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.17500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.67500305 11.72200012 Tm [(glyc)-1(o)1(syl)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.39700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.89700317 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.26600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.76600647 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.70700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.20700073 11.72200012 Tm [(oxid)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.19500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.69500732 11.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.20001221 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.70001221 11.72200012 Tm [(da)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mag)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.27099991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.77099991 27.3220005 Tm [(repair.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.03499985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.53499985 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.34200287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.84200287 27.3220005 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.22299957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.72299957 27.3220005 Tm [(exc)-1(ises)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.73800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.23800659 27.3220005 Tm [(ad)1(e)-1(nine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.66900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.16900635 27.3220005 Tm [(ba)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.33000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.83000183 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.54100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.04100037 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.04199219 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.54199219 27.3220005 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.04699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.54699707 27.3220005 Tm [(ba)1(c)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(bo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.95000076 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45000076 42.92200089 Tm [(sites)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.63700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.13700104 42.92200089 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.43399811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.93399811 42.92200089 Tm [(ad)1(e)-1(nine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.36500549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.86500549 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42599487 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.92599487 42.92200089 Tm [(inapp)1(ropr)1(i)-1(a)1(tely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.66799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.16799927 42.92200089 Tm [(pa)1(i)-1(r)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.58500671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.08500671 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.48098755 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.98098755 42.92200089 Tm [(guanine)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.01800537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(cy)-1(t)1(osine)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.73099899 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.23099899 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.38899994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.88899994 58.52199936 Tm [(8-oxo)1(-7,8)-1(-)1(dihydr)1(oguanine)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.98399353 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.48399353 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.45899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.95899963 58.52199936 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.92900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.42900085 58.52199936 Tm [(oxid)1(atively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.57598877 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.07598877 58.52199936 Tm [(da)1(maged)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.83499146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.50499916 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.00499916 74.12200165 Tm [(lesion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5019989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.0019989 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.80899811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30899811 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.61599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.11599731 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.67700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.17700195 74.12200165 Tm [(localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.86000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.36000061 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.43499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.93499756 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.93600464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.43600464 74.12200165 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.2539978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.7539978 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.03100586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.53100586 74.12200165 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(ri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(a.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.14099979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 89.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.49000168 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.99000168 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.93099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.43099976 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.88700104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.38700104 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.90299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.40299988 89.72200012 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.40600586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.90600586 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.84700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.34700012 89.72200012 Tm [(herita)1(ble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.40400696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.90400696 89.72200012 Tm [(predisp)1(ositio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.55899048 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.05899048 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.13400269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.63400269 89.72200012 Tm [(colon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.53100586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 105.3219986 Tm [(st)1(omach)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.47999954 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.97999954 105.3219986 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.23600006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.73600006 105.3219986 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.46800232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.96800232 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.88999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.38999939 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.96000671 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.46000671 105.3219986 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.80200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.30200195 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.24200439 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.74200439 105.3219986 Tm [(i)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 0.75 m 108.5 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 17.10000038 m 108.5 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 33.45000076 m 108.5 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 49.80000305 m 108.5 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 66.15000153 m 108.5 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 82.5 m 108.5 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 98.84999847 m 108.5 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 108.5 115.19999695 m 108.5 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>